High proliferation rate and TNM stage but not histomorphological subtype are independent prognostic markers for overall survival in papillary renal cell carcinoma.

abstract：:Schistosoma haematobium infection is a common occurrence in Africa and the Middle East and is the world's leading cause of hematuria. Since more North Americans are venturing into endemic areas and more residents of endemic areas are seeking medical care in North America, pathologists must be able not only to diagnose...

journal_title：Human pathology

authors： Smith JH,Christie JD

更新日期：1986-04-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...

journal_title：Human pathology

authors： Kumazaki K,Nakayama M,Suehara N,Wada Y

更新日期：2002-11-01 00:00:00

abstract：:Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced n...

journal_title：Human pathology

authors： McCullough J

更新日期：1983-03-01 00:00:00

abstract：:We examined the infection of herpes simplex virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significan...

journal_title：Human pathology

authors： Oda Y,Okada Y,Katsuda S,Nakanishi I

更新日期：1994-10-01 00:00:00

abstract：:Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...

journal_title：Human pathology

authors： Hamanaka W,Motoi N,Ishikawa S,Ushijima M,Inamura K,Hatano S,Uehara H,Okumura S,Nakagawa K,Nishio M,Horai T,Aburatani H,Matsuura M,Iwasaki A,Ishikawa Y

更新日期：2014-05-01 00:00:00

abstract：:Papillary renal cell carcinoma (PRCC), a morphologically and genetically distinct subtype of RCC, is morphologically separated into 2 subtypes, type 1 and 2, for prognostic purposes. Type 1 PRCC (single layer of small cells, scant pale cytoplasm) is more common and has a favorable prognosis compared with type 2 (pseud...

journal_title：Human pathology

authors： Kunju LP,Wojno K,Wolf JS Jr,Cheng L,Shah RB

更新日期：2008-01-01 00:00:00

abstract：:A unique case of primary papillary hyperplasia of the gallbladder and cystic and common bile ducts occurring in a young female without calculi, ulcerative colitis, or primary sclerosing cholangitis is reported. The papillary lesion involved the mucosa of the entire gallbladder and of the cystic and common bile ducts. ...

journal_title：Human pathology

authors： Albores-Saavedra J,Defortuna SM,Smothermon WE

更新日期：1990-02-01 00:00:00

abstract：:Ovarian surface epithelial carcinomas are routinely subclassified by pathologists based on tumor cell type and grade. It is controversial whether cell type or grade is superior in predicting patient response to treatment or survival, in patients stratified by stage of disease. The aim of this study was to uniformly ap...

journal_title：Human pathology

authors： Gilks CB,Ionescu DN,Kalloger SE,Köbel M,Irving J,Clarke B,Santos J,Le N,Moravan V,Swenerton K,Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency.

更新日期：2008-08-01 00:00:00

abstract：:Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...

journal_title：Human pathology

authors： Häusler M,Schaade L,Ramaekers VT,Doenges M,Heimann G,Sellhaus B

更新日期：2003-03-01 00:00:00

abstract：:The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...

journal_title：Human pathology

authors： Castellani C,Padalino M,China P,Fedrigo M,Frescura C,Milanesi O,Stellin G,Thiene G,Angelini A

更新日期：2010-11-01 00:00:00

abstract：:The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...

journal_title：Human pathology

authors： Mangia A,Malfettone A,Saponaro C,Tommasi S,Simone G,Paradiso A

更新日期：2011-11-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans is genetically characterized by the translocation t(17;22)(q22;q13) resulting in the PDGFB/COL1A1 fusion gene. Fluorescence in situ hybridization with specific probes enables a rapid detection of this gene. In this study, the presence of the translocation t(17;22)(q22;q13) by fluorescen...

journal_title：Human pathology

authors： Segura S,Salgado R,Toll A,Martín-Ezquerra G,Yébenes M,Sáez A,Solé F,Barranco C,Umbert P,Espinet B,Pujol RM

更新日期：2011-02-01 00:00:00

abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...

journal_title：Human pathology

authors： Hervieu V,Christa L,Gouysse G,Bouvier R,Chayvialle JA,Bréchot C,Scoazec JY

更新日期：2006-08-01 00:00:00

abstract：:The current system of pathologic classification of human breast cancers does not take into account the biologic determinants of prognosis, nor is there a consensus regarding the progression from in situ to invasive carcinoma. The present study compared the molecular phenotypes of in situ and invasive components of bre...

journal_title：Human pathology

authors： Martins D,Sousa B,Lopes N,Gomes M,Veronese L,Albergaria A,Paredes J,Schmitt F

更新日期：2011-10-01 00:00:00

abstract：:Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...

journal_title：Human pathology

authors： Fleming KE,Ly TY,Pasternak S,Godlewski M,Doucette S,Walsh NM

更新日期：2014-05-01 00:00:00

abstract：:A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms. In this series, CMFs were found in patients of all age groups, with no predominance between sexes. Long bone tumors wer...

journal_title：Human pathology

authors： Zillmer DA,Dorfman HD

更新日期：1989-10-01 00:00:00

abstract：:Promyelocytic leukemia zinc finger is a zinc finger transcription factor that functions as a transcriptional repressor. Its expression has been shown to be down-regulated in hematopoietic, melanocytic, and mesothelial malignancies. Histone H1.5 is a variant of histone H1, a family of linker proteins that organizes chr...

journal_title：Human pathology

authors： Hechtman JF,Beasley MB,Kinoshita Y,Ko HM,Hao K,Burstein DE

更新日期：2013-07-01 00:00:00

abstract：:Aberrant expression of the antiapoptotic protein BCL (B-cell lymphoma)-2 in neoplastic germinal centers is one of the diagnostic hallmarks of follicular lymphoma. If BCL-2 cannot be detected by immunohistochemistry, the distinction between florid follicular hyperplasia and follicular lymphoma might become a diagnostic...

journal_title：Human pathology

authors： Hoeller S,Bihl MP,Zihler D,Cogliatti S,Ponzoni M,Zettl A,Went P,Foerster A,Hirschmann P,Tzankov A,Dirnhofer S

更新日期：2012-03-01 00:00:00

abstract：:Perineural invasion is a histologic feature usually diagnostic of invasion in malignancies. In the breast, however, it has been associated with benign lesions such as sclerosing adenosis (SA), complex sclerosing lesion/radial scar (CSL/RS), and ductal carcinoma in situ (DCIS). This article describes perineural invasio...

journal_title：Human pathology

authors： Gobbi H,Jensen RA,Simpson JF,Olson SJ,Page DL

更新日期：2001-08-01 00:00:00

abstract：:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...

journal_title：Human pathology

authors： Davidson B,Holth A,Hellesylt E,Hadar R,Katz B,Tropé CG,Reich R

更新日期：2016-02-01 00:00:00

abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...

journal_title：Human pathology

authors： Thurberg BL,Politei JM

更新日期：2012-04-01 00:00:00

abstract：:Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...

journal_title：Human pathology

authors： Konishi E,Nakashima Y,Iwasaki T

更新日期：2003-02-01 00:00:00

abstract：:We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750...

journal_title：Human pathology

authors： Weissferdt A,Kalhor N,Bishop JA,Jang SJ,Ro J,Petersson F,Wu B,Langman G,Bancroft H,Bi Y,Meng Y,Medeiros F,Brunnstrom H,Spagnolo D,Chai SM,Laycock A,Wakely PE Jr,Elmberger G,Soares FA,Campos AH,Gumurdulu D,Alvara

更新日期：2018-03-01 00:00:00

abstract：:The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...

journal_title：Human pathology

authors： Bonkhoff H,Stein U,Remberger K

更新日期：1993-03-01 00:00:00

abstract：:The light microscopic diagnosis of large cell undifferentiated carcinoma of the lung is known to be highly subjective and shows poor interobserver reproducibility; the very existence of this tumor as a separate entity has been challenged. The ultrastructure of seven large cell undifferentiated carcinomas was examined ...

journal_title：Human pathology

authors： Churg A

更新日期：1978-03-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...

journal_title：Human pathology

authors： Murakami I,Matsushita M,Iwasaki T,Kuwamoto S,Kato M,Horie Y,Hayashi K,Imamura T,Morimoto A,Imashuku S,Gogusev J,Jaubert F,Takata K,Oka T,Yoshino T

更新日期：2014-01-01 00:00:00

abstract：:Metanephric stromal tumors (MSTs) are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors, along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of ...

journal_title：Human pathology

authors： Marsden L,Jennings LJ,Gadd S,Yu M,Perlman EJ,Cajaiba MM

更新日期：2017-02-01 00:00:00

abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...

journal_title：Human pathology

authors： Karpowicz MK,Shalmon B,Molberg KH,El-Naggar AK

更新日期：2011-09-01 00:00:00

abstract：:Fibroepithelial lesions (FEL) of the breast are notoriously difficult to classify on core needle biopsies. The goal of this study was to evaluate interobserver variability and accuracy of subclassifying difficult FELs into fibroadenoma (FA) and phyllodes tumors (PTs). We identified 50 breast core needle biopsies, init...

journal_title：Human pathology

authors： Bandyopadhyay S,Barak S,Hayek K,Thomas S,Saeed H,Beydoun R,Shi D,Arabi H,Ruterbusch J,Cote M,Ali-Fehmi R

更新日期：2016-01-01 00:00:00

abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...

journal_title：Human pathology

authors： Katz B,Tropé CG,Reich R,Davidson B

更新日期：2015-09-01 00:00:00