Orbital osteoclastoma of apparent extraskeletal origin in a pagetic patient: a case report.

Abstract:

:A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparent either operatively, microscopically, or on preoperative computed tomographic scans. The neoplasm has not recurred in a 3-year follow-up. In addition to the fact that osteoclastoma complicating PBD is rare, the extraskeletal origin of the tumor is a matter of interest and can be tentatively explained by an unusually powerful systemic stimulus acting on circulating osteoclast precursors. HUM PATHOL 31:1527-1531.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Pecorella I,Ciardi A,Amadeo G,Baiocchini A,Marasco A,Di Tondo U

doi

10.1053/hupa.2000.20411

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1527-31

issue

12

eissn

0046-8177

issn

1532-8392

pii

S0046817700737117

journal_volume

31

pub_type

杂志文章
  • The histone methyltransferase G9a: a new therapeutic target in biliary tract cancer.

    abstract::The histone methyltransferase G9a (EHMT2) is a key enzyme for dimethylation of lysine 9 at histone 3 (H3K9me2), a suppressive epigenetic mark. G9a is over-expressed in tumor cells and contributes to cancer aggressiveness. Biliary tract cancer (BTC) is a rare cancer with dismal prognosis due to a lack of effective ther...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2017.11.003

    authors: Mayr C,Helm K,Jakab M,Ritter M,Shrestha R,Makaju R,Wagner A,Pichler M,Beyreis M,Staettner S,Jaeger T,Klieser E,Kiesslich T,Neureiter D

    更新日期:2018-02-01 00:00:00

  • The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.

    abstract::Breast cancer is one of the common malignant diseases among women in Japan as well as in western countries, and its incidence continues to increase. Normal mammary duct epithelial cells exhibit a well-organized apicobasal polarity, which forms the basis for their specific structure and function. Although the loss of e...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2007.11.001

    authors: Kojima Y,Akimoto K,Nagashima Y,Ishiguro H,Shirai S,Chishima T,Ichikawa Y,Ishikawa T,Sasaki T,Kubota Y,Inayama Y,Aoki I,Ohno S,Shimada H

    更新日期:2008-06-01 00:00:00

  • MicroRNAs in Ovarian Cancer.

    abstract::Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humpath.2015.06.013

    authors: Katz B,Tropé CG,Reich R,Davidson B

    更新日期:2015-09-01 00:00:00

  • Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma.

    abstract::Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. Mammary analogue secretory carcinoma's morphology is not entirely specific and overlaps with other salivary gland tumors. Documenting ETV6 rearrangement is confirmatory, but most laboratories are not...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2013.03.017

    authors: Bishop JA,Yonescu R,Batista D,Begum S,Eisele DW,Westra WH

    更新日期:2013-10-01 00:00:00

  • Prominent intrasinusoidal infiltration of the bone marrow by mantle cell lymphoma.

    abstract::Intrasinusoidal infiltration of bone marrow (BM) may accompany several malignant lymphoproliferative disorders. In small B-cell lymphomas, this pattern is considered specific for splenic marginal zone lymphoma (SMZL) when exclusive or prominent, although it may occur in other subtypes of non-Hodgkin's lymphomas (NHLs)...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(03)00286-7

    authors: Schenka AA,Gascoyne RD,Duchayne E,Delsol G,Brousset P

    更新日期:2003-08-01 00:00:00

  • Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system.

    abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.humpath.2006.10.006

    authors: Massone C,Soyer HP,Lozzi GP,Di Stefani A,Leinweber B,Gabler G,Asgari M,Boldrini R,Bugatti L,Canzonieri V,Ferrara G,Kodama K,Mehregan D,Rongioletti F,Janjua SA,Mashayekhi V,Vassilaki I,Zelger B,Zgavec B,Cerroni L,K

    更新日期:2007-04-01 00:00:00

  • Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms.

    abstract::Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2018.07.010

    authors: Lu Z,Al-Obaidy K,Cheng L,Perry KD,Grignon DJ,Williamson SR

    更新日期:2018-12-01 00:00:00

  • Diagnosis of chronic endometritis in biopsies with stromal breakdown.

    abstract::Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes ("disordered proliferative" and "anovulatory" patterns), and stromal breakdown. We reviewe...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2006.09.002

    authors: Gilmore H,Fleischhacker D,Hecht JL

    更新日期:2007-04-01 00:00:00

  • "Thanatosomes": a unifying morphogenetic concept for tumor hyaline globules related to apoptosis.

    abstract::Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2000.20376

    authors: Papadimitriou JC,Drachenberg CB,Brenner DS,Newkirk C,Trump BF,Silverberg SG

    更新日期:2000-12-01 00:00:00

  • Focal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation.

    abstract::Heavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for rela...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2006.07.011

    authors: Chan GS,Chim S,Fan YS,Chan KW

    更新日期:2006-12-01 00:00:00

  • GAEC1 and colorectal cancer: a study of the relationships between a novel oncogene and clinicopathologic features.

    abstract::GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2009.11.014

    authors: Gopalan V,Smith RA,Nassiri MR,Yasuda K,Salajegheh A,Kim SY,Ho YH,Weinstein S,Tang JC,Lam AK

    更新日期:2010-07-01 00:00:00

  • Intertubular growth in pure seminomas: associations with poor prognostic parameters.

    abstract::Clinical stage I seminomas are effectively treated with surgery raising concerns as to when to give adjuvant radiation therapy given the risk of secondary malignancies. A recent randomized trial found tumor size and rete testis invasion to be the strongest predictors of relapse in clinical stage I seminomas. These 2 p...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2005.03.011

    authors: Browne TJ,Richie JP,Gilligan TD,Rubin MA

    更新日期:2005-06-01 00:00:00

  • Immunohistochemical analysis of retroperitoneal Müllerian cyst.

    abstract::Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2003.12

    authors: Konishi E,Nakashima Y,Iwasaki T

    更新日期:2003-02-01 00:00:00

  • Recurrent "syncytial variant" of Hodgkin's disease: an immunohistologic diagnosis.

    abstract::A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(87)80247-2

    authors: Blaustein JC,Lewkow L

    更新日期:1987-07-01 00:00:00

  • Follicular dendritic cells: origin, function, and different disease-associated patterns.

    abstract::Follicular dendritic cells (FDCs) are a specialized type of antigen-presenting dendritic cells that are largely restricted to lymphoid follicles. They form dense three-dimensional meshwork patterns within benign follicles, which maintain the follicular architecture. The FDC function is to bind and retain antigens by l...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humpath.2012.10.005

    authors: Rezk SA,Nathwani BN,Zhao X,Weiss LM

    更新日期:2013-06-01 00:00:00

  • Proliferative activity of renal cell carcinoma associated with acquired cystic disease of the kidney: comparison with typical renal cell carcinoma.

    abstract::To assess the proliferative activity of renal cell carcinoma (RCC-A) in patients with acquired cystic disease of the kidney (ACDK) after long-term hemodialysis, we analyzed cell cycle, DNA ploidy, and S-phase fraction by flow cytometry (FCM) and proliferating cell nuclear antigen (PCNA) labeling index by immunohistoch...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2002.30188

    authors: Ikeda R,Tanaka T,Moriyama MT,Kawamura K,Miyazawa K,Suzuki K

    更新日期:2002-02-01 00:00:00

  • Pathology data integration with eXtensible Markup Language.

    abstract::It is impossible to overstate the importance of XML (eXtensible Markup Language) as a data organization tool. With XML, pathologists can annotate all of their data (clinical and anatomic) in a format that can transform every pathology report into a database, without compromising narrative structure. The purpose of thi...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humpath.2004.10.013

    authors: Berman JJ

    更新日期:2005-02-01 00:00:00

  • Expression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma.

    abstract::Brain metastases (BMs) are common complications of adenocarcinomas (ADCs) of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin (mTOR) can influence the metastatic potential of various tumors, the role of mTOR c...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.humpath.2016.12.012

    authors: Krencz I,Sebestyén A,Fábián K,Márk Á,Moldvay J,Khoor A,Kopper L,Pápay J

    更新日期:2017-04-01 00:00:00

  • Pleural effusion as a complication of solitary eosinophilic granuloma of the rib.

    abstract::A 57 year old man presented with a two week history of right sided chest pain. An admission chest x-ray examination revealed a 2 by 1 cm. lytic lesion of the ninth right rib and right sided pleural effusion. The patient underwent a right thoracotomy during which 700 cc. of blood tinged pleural fluid was drained and a ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(80)80080-3

    authors: Pappas CA,Rheinlander HF,Stadecker MJ

    更新日期:1980-11-01 00:00:00

  • Contributions of pediatrics and pediatric pathology to the body of knowledge regarding human disease.

    abstract::A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humpath.2009.06.017

    authors: Nezelof C,Seemayer TA,Bridge JA

    更新日期:2010-03-01 00:00:00

  • Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies.

    abstract::The diagnosis of placental site trophoblastic lesions, particularly the distinction of a placental site trophoblastic tumor from an exaggerated placental site, can be difficult. Mel-CAM (also known as CD146 and MUC18) is a recently recognized cell adhesion molecule belonging to the immunoglobin gene superfamily that s...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(98)90386-0

    authors: Shih IM,Kurman RJ

    更新日期:1998-01-01 00:00:00

  • The number and growth pattern of plasmacytoid dendritic cells vary in different types of reactive lymph nodes: an immunohistochemical study.

    abstract::Plasmacytoid dendritic cells, which play a fundamental role in the innate immune response, are best known for their presence in hyaline-vascular Castleman disease and histiocytic necrotizing lymphadenitis. The relative number and distribution in many reactive entities as detected using more sensitive methods are uncer...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2012.08.020

    authors: Rollins-Raval MA,Marafioti T,Swerdlow SH,Roth CG

    更新日期:2013-06-01 00:00:00

  • Mallory bodies in scar adenocarcinoma of the lung.

    abstract::A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(82)80143-3

    authors: Michel RP,Limacher JJ,Kimoff RJ

    更新日期:1982-01-01 00:00:00

  • Incidental healed postinfectious glomerulonephritis: a study of 1012 renal biopsy specimens examined by electron microscopy.

    abstract::Glomerulonephritis (GN) characterized by immune complex deposits typical of postinfectious GN but with a paucity or absence of overt clinical symptoms and/or urinary abnormalities may occur after a group A streptococcus infection. The overall incidence of this type of subclinical GN is not known. To address this quest...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2003.53

    authors: Haas M

    更新日期:2003-01-01 00:00:00

  • Uterine stromal neoplasms: a clinicopathologic and DNA flow cytometric correlation.

    abstract::Twenty-five uterine stromal neoplasms (five stromal nodules and 12 low-grade and eight high-grade stromal sarcomas) were studied to determine the correlation between clinicopathologic features, flow cytometric tumor DNA content and proliferative fraction, and patient outcome. Fifteen of the 20 sarcomas (five of them h...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(91)90179-s

    authors: el-Naggar AK,Abdul-Karim FW,Silva EG,McLemore D,Garnsey L

    更新日期:1991-09-01 00:00:00

  • Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma.

    abstract::Syndecan-1, a cell-surface transmembrane heparan sulfate proteoglycan, has been reported to correlate with the biologic behavior of malignant tumors in various organs. We examined the correlation between the expression of syndecan-1 at the protein and mRNA levels and clinicopathologic features of 37 intrahepatic chola...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(03)00336-8

    authors: Harada K,Masuda S,Hirano M,Nakanuma Y

    更新日期:2003-09-01 00:00:00

  • DNA ploidy by image cytometry and karyotype in spontaneous abortion.

    abstract::We compared the DNA content (DI) by cell image analysis with the karyotype and morphological phenotype of paraffin-embedded tissues from 51 spontaneous abortions. The study included 21 cases with triploid, 19 cases with diploid, and 11 cases with aneuploid (monosomic, trisomic, or mosaic) karyotype. Measurements were ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(98)90209-x

    authors: Kaspar HG,Kraemer BB,Kraus FT

    更新日期:1998-09-01 00:00:00

  • Tumor budding is associated with poor prognosis of oral squamous cell carcinoma and histologically represents an epithelial-mesenchymal transition process.

    abstract::In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2018.06.012

    authors: Hong KO,Oh KY,Shin WJ,Yoon HJ,Lee JI,Hong SD

    更新日期:2018-10-01 00:00:00

  • Specimen collection and transport.

    abstract::The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/s0046-8177(76)80040-8

    authors: Matsen JM,Ederer GM

    更新日期:1976-05-01 00:00:00

  • Comparison between the location and the histomorphological/immunohistochemical characteristics of noninvasive neoplasms of the ampulla of Vater.

    abstract::To determine useful factors when selecting an appropriate procedure for noninvasive ampullary neoplasia, we investigated the relationship between the location and the histomorphological/immunohistochemical characteristics of 56 noninvasive ampullary neoplasms obtained by endoscopic papillectomy (EP). All subjects were...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2014.05.013

    authors: Yamamoto Y,Nemoto T,Okubo Y,Nihonyanagi Y,Ishiwatari T,Takuma K,Tochigi N,Okano N,Wakayama M,Igarashi Y,Shibuya K

    更新日期:2014-09-01 00:00:00