Abstract:
:We studied the histopathologic, immunohistochemical, and ultrastructural features of the extracellular matrix (ECM) in 20 immunologically defined large-cell lymphomas, including immunoblastic sarcoma of B cells (three patients), peripheral T cell lymphoma (five patients), large non-cleaved follicular center cell (FCC) lymphoma (nine patients), and non-marking large-cell lymphoma (three patients). Immunohistochemical studies were performed with antibodies to laminin, fibronectin, and collagen types I, III, IV, and V. The immunologically defined subgroups demonstrated characteristic differences in ECM in light microscopic appearance, composition, and ultrastructural features. Immunoblastic sarcomas of B cells showed delicate intercellular bands that were apparent only at high power but were distinct in exhibiting focal staining for basement membrane elements (laminin and type IV collagen) in addition to type I collagen and fibronectin. Electron microscopically, no basal lamina were apparent, although the collagen fibers were embedded in a dense matrix not seen in the other lymphomas. All peripheral T cell lymphomas exhibited a packeting pattern of intercellular bands and were distinguished by the frequent presence of intense pericellular staining for type V collagen as well as by focal pericellular staining for types I and III collagen. The latter finding corresponded to extensive areas of direct contact between tumor cells and the ECM by electron microscopy. The large non-cleaved FCC lymphomas and the non-marking large-cell lymphomas demonstrated both diffuse and compartmentalizing arrangements of intercellular bands that frequently coexisted and stained predominantly for fibronectin and types I and III collagen. All groups demonstrated myofibroblasts and fibroblasts partially or completely separating the ECM from tumor cells, suggesting that most of the ECM is part of a reaction to these lymphomas. These studies show more variation in light microscopic appearance, composition, and ultrastructural relationships of the intercellular and pericellular ECM than was apparent in earlier studies of cleaved FCC lymphomas.
journal_name
Hum Patholjournal_title
Human pathologyauthors
McCurley TL,Gay RE,Gay S,Glick AD,Jones MR,Haralson MA,Collins RDdoi
10.1016/0046-8177(89)90181-0subject
Has Abstractpub_date
1989-02-01 00:00:00pages
164-73issue
2eissn
0046-8177issn
1532-8392pii
0046-8177(89)90181-0journal_volume
20pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. Mammary analogue secretory carcinoma's morphology is not entirely specific and overlaps with other salivary gland tumors. Documenting ETV6 rearrangement is confirmatory, but most laboratories are not...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.017
更新日期:2013-10-01 00:00:00
abstract::Hemangiopericytoma and fibrosarcoma represented at one time two of the most common diagnoses in soft tissue pathology. Both terms are now largely extinct. This article will review the clinicopathologic, immunohistochemical and molecular genetic advances that have led to these changes, and review the pathologic feature...
journal_title:Human pathology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.humpath.2019.10.001
更新日期:2020-01-01 00:00:00
abstract::Pseudovascular adenoid squamous cell carcinoma (PASCC) is a variant epithelial neoplasm with the ability to simulate the growth pattern of angiosarcoma. It has been documented in the breast, skin, and, recently, lung. We describe three additional examples of pulmonary PASCC occurring in two men and one woman. The pati...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90145-7
更新日期:1994-04-01 00:00:00
abstract::We studied c-erbB-2, p53, and nm23 gene products in 112 primary breast carcinomas. Fifty patients were aged 35 years or younger, and 62 were aged 36 to 50. Clinicopathological criteria including clinical stage, hormone receptor status, histological types, histological grades, and lymph node status, were reviewed. Dise...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90111-3
更新日期:1998-04-01 00:00:00
abstract::This report describes the biopsy findings in four of 30 patients treated with cadaver osteochondral shell allografts for osteoarthritis in the knee. This study demonstrates that graft cartilage cells can survive in excess of 25 months, and that host bone can completely replace graft bone by creeping substitution. An i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80093-2
更新日期:1977-11-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2007.05.020
更新日期:2007-09-01 00:00:00
abstract::It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.08.016
更新日期:2013-05-01 00:00:00
abstract::The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90352-4
更新日期:1992-07-01 00:00:00
abstract::A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90064-a
更新日期:1992-12-01 00:00:00
abstract::Ovarian surface epithelial carcinomas are routinely subclassified by pathologists based on tumor cell type and grade. It is controversial whether cell type or grade is superior in predicting patient response to treatment or survival, in patients stratified by stage of disease. The aim of this study was to uniformly ap...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.01.003
更新日期:2008-08-01 00:00:00
abstract::A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90017-8
更新日期:1989-05-01 00:00:00
abstract::The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80285-5
更新日期:1988-11-01 00:00:00
abstract::Two extraskeletal myxoid chondrosarcomas were examined by electron microscopy. In addition to the well-described ultrastructural features indicative of chondroblastic origin, both of these chondrosarcomas had unusual parallel microtubules packed within rough endoplasmic reticulum. This paper reviews the differential d...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80036-3
更新日期:1986-05-01 00:00:00
abstract::Cell growth in the normal prostate is regulated by a delicate balance between cell death and cell proliferation (ie, apoptotic v proliferative activity). Disruption of the molecular mechanisms that regulate these two processes may underline the abnormal growth of the gland leading to benign prostatic hyperplasia (BPH)...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90396-2
更新日期:1996-07-01 00:00:00
abstract::Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90287-2
更新日期:1997-01-01 00:00:00
abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90448-8
更新日期:1998-08-01 00:00:00
abstract::Organ transplant recipients have an increased tumor incidence owing to their immunocompromised state. The origin of such tumors, whether donor or recipient, will have a clinical impact on decision-making concerning immunosuppressive therapy, retransplantation, and for recipients of other organs from the same donors. W...
journal_title:Human pathology
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::We investigated the use of remote video microscopy (telepathology) to assist in the diagnosis of 52 neurosurgical frozen section cases. The TelMed system (Discovery Medical Systems, Overland Park, KS), in which the referring pathologist selects appropriate fields for transmission to the consultant, was used for the st...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90142-4
更新日期:1993-08-01 00:00:00
abstract::Glomerulonephritis (GN) characterized by immune complex deposits typical of postinfectious GN but with a paucity or absence of overt clinical symptoms and/or urinary abnormalities may occur after a group A streptococcus infection. The overall incidence of this type of subclinical GN is not known. To address this quest...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.53
更新日期:2003-01-01 00:00:00
abstract::p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.06.014
更新日期:2017-08-01 00:00:00
abstract::Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.06.016
更新日期:2005-09-01 00:00:00
abstract::Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.003
更新日期:2013-10-01 00:00:00
abstract::Gastrointestinal stromal tumors are a group of mesenchymal tumors arising from the wall of the gastrointestinal tract that are characterized by activating mutations in KIT or PDGFRA. Their proper recognition is important clinically because of their potential responsiveness to targeted therapies. We report a case of du...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.09.017
更新日期:2009-04-01 00:00:00
abstract::Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.06.019
更新日期:2019-01-01 00:00:00
abstract::Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.125381
更新日期:2002-08-01 00:00:00
abstract::Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.03.007
更新日期:2017-06-01 00:00:00
abstract::Meconium-associated vascular necrosis (MAVN) is a histological abnormality of human placental chorionic vessels that is associated with poor neonatal outcome. We tested the hypothesis that MAVN shows apoptosis in the walls of chorionic vessels. Archival placental specimens with MAVN (n = 5) were compared with specimen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.12.002
更新日期:2004-04-01 00:00:00
abstract::A small number (4% to 6%) of primary malignant lymphomas arising in the intestines express the EBV genome. However, in these tumors, the viral genotype and the role of tumor suppressor gene p53 have not been investigated. We sought to determine what genotype of EBV is frequently involved and whether the expression of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90030-8
更新日期:1999-10-01 00:00:00
abstract::The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.11.002
更新日期:2012-09-01 00:00:00
abstract::This report reviews the goals and objectives of residency training in pathology as defined during the initial two conferences of program directors. Specific emphasis is given to future needs and in particular the background and capabilities of the persons who will be practicing pathology in the 1980's and 1990's. In t...
journal_title:Human pathology
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00