Abstract:
:Meconium-associated vascular necrosis (MAVN) is a histological abnormality of human placental chorionic vessels that is associated with poor neonatal outcome. We tested the hypothesis that MAVN shows apoptosis in the walls of chorionic vessels. Archival placental specimens with MAVN (n = 5) were compared with specimens from uncomplicated pregnancies at term (n = 5) and from placentas with intense chorionic vasculitis associated with acute chorioamnionitis with (n = 5) or without (n = 5) a clinical history of meconium in the amniotic fluid. Sections from all placentas were processed by the TUNEL method, and 2 observers who were blinded to specimen diagnosis quantified the immunofluorescent TUNEL staining in both the amnion-facing and villous-facing walls of the larger chorionic vessels in each specimen. Compared with the other 3 groups, only the amnion-facing wall of chorionic vessels in MAVN showed a significantly greater number of apoptotic cells. This was verified by morphological criteria and caspase 3 staining. There were limited or no detectable TUNEL-stained cells in either the villous-facing walls of vessels in the MAVN specimens or in any of the vessels of the placentas from uncomplicated pregnancies. There was a negligible level of apoptosis in chorionic vessels of placentas with intense chorionic vasculitis, with or without meconium, despite the inflammatory response or presence of meconium. We conclude that apoptosis contributes to the pathophysiology of MAVN.
journal_name
Hum Patholjournal_title
Human pathologyauthors
King EL,Redline RW,Smith SD,Kraus FT,Sadovsky Y,Nelson DMdoi
10.1016/j.humpath.2003.12.002subject
Has Abstractpub_date
2004-04-01 00:00:00pages
412-7issue
4eissn
0046-8177issn
1532-8392pii
S0046817703006701journal_volume
35pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for carcinomas of the large intestine are reported herein. ...
journal_title:Human pathology
pub_type: 指南,杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.014
更新日期:2010-07-01 00:00:00
abstract::Telomerase is a ribonucleoprotein enzyme associated with cellular immortality and has been detected in the vast majority of adult tumors. Wilms tumor is a histologically diverse embryonal malignancy of childhood, and the histological features of Wilms tumor and its precursor lesion, the nephrogenic rest, recapitulate ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90072-7
更新日期:1998-05-01 00:00:00
abstract::Our previous investigations of transforming growth factor types beta 1 and beta 2 (TGF beta s) showed negative or positive autocrine growth regulation of gliomas in vitro. Near-diploid gliomas were inhibited by the TGF beta s, whereas a stimulatory response correlated with progressive anaplasia and karyotypic divergen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90118-x
更新日期:1994-05-01 00:00:00
abstract::Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papillomavirus infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluat...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.09.019
更新日期:2017-01-01 00:00:00
abstract::Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.013
更新日期:2010-10-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.05.028
更新日期:2014-01-01 00:00:00
abstract::A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2020.03.007
更新日期:2020-05-01 00:00:00
abstract::Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in breast cancers. An archive of 322 formalin-fixed and paraffin-embedded ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.10.017
更新日期:2019-03-01 00:00:00
abstract::To assess the proliferative activity of renal cell carcinoma (RCC-A) in patients with acquired cystic disease of the kidney (ACDK) after long-term hemodialysis, we analyzed cell cycle, DNA ploidy, and S-phase fraction by flow cytometry (FCM) and proliferating cell nuclear antigen (PCNA) labeling index by immunohistoch...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30188
更新日期:2002-02-01 00:00:00
abstract::We used light microscopy to examine, at autopsy, bronchial arteries in three patients with cystic fibrosis who died, respectively, 10, 16, and 28 months after bronchial artery embolization with barium sulfate-impregnated polyvinyl alcohol (PVA) to control hemoptysis. PVA was not identified beyond the midsegmental bron...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80204-1
更新日期:1988-05-01 00:00:00
abstract::We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.12.010
更新日期:2007-06-01 00:00:00
abstract::A 41 year old woman was treated for metrorrhagia with Ovral three times daily for one week, followed by a single daily dose for one month. Hysterectomy and bilateral salpingo-oophorectomy were performed. Histologically the mucosa of both fallopian tubes had large areas of decidual reaction underlying atrophic epitheli...
journal_title:Human pathology
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Serous surface carcinoma (SSC) is a neoplasm histologically indistinguishable from typical serous carcinomas that arise from the ovary but has a distinct clinical presentation. It is characterized by widespread peritoneal dissemination at presentation, but the ovaries are grossly normal in size and shape. If the carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90277-0
更新日期:1999-02-01 00:00:00
abstract::Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.01.019
更新日期:2015-05-01 00:00:00
abstract::Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.06.019
更新日期:2019-01-01 00:00:00
abstract::The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80052-7
更新日期:1987-08-01 00:00:00
abstract::Ultrastructural features of bilateral testicular biopsy materials, obtained from both tumor and nontumor areas of the testis of a 27-year-old man with congenital adrenal hyperplasia, revealed a number of pathologic changes. Germ cell hypoplasia and extratubular cellular hyperplasia were noticed in the nontumor portion...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80244-5
更新日期:1983-02-01 00:00:00
abstract::Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.03.028
更新日期:2012-12-01 00:00:00
abstract::Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.010
更新日期:2015-03-01 00:00:00
abstract::Seminoma and sarcoidosis do not seem to be associated diseases, judging from epidemiologic data. The presence of these two diseases in the patient whose case is reported may have been coincidental. It was observed, however, that when the testis tumor appeared in this patient, the longstanding sarcoid lesions significa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80041-6
更新日期:1984-04-01 00:00:00
abstract::Glomerulonephritis (GN) characterized by immune complex deposits typical of postinfectious GN but with a paucity or absence of overt clinical symptoms and/or urinary abnormalities may occur after a group A streptococcus infection. The overall incidence of this type of subclinical GN is not known. To address this quest...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.53
更新日期:2003-01-01 00:00:00
abstract::Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80046-9
更新日期:1981-07-01 00:00:00
abstract::To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.04.024
更新日期:2014-11-01 00:00:00
abstract::A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90221-0
更新日期:1998-02-01 00:00:00
abstract::The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90033-d
更新日期:1993-03-01 00:00:00
abstract::The relationship between nuclear diameter and biologic behavior was studied in 127 cases of thyroid carcinoma. Using a sonic digitizer coupled to a minicomputer, nuclear diameters of 200 randomly selected cancer cells from each case (hematoxylineosin-stained paraffin sections) projected at X 400 magnification were tra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80409-4
更新日期:1987-12-01 00:00:00
abstract::A renal biopsy of a 57-year-old man with nephrotic syndrome revealed marked glomerular deposition of Congo red-positive, bire-fringent material characteristic for amyloid. Ultrastructurally, however, this material is composed of nonbranching, haphazardly arranged fibrils of approximately three times the thickness of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90059-e
更新日期:1990-08-01 00:00:00
abstract::A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80143-3
更新日期:1982-01-01 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(99)90040-0
更新日期:1999-10-01 00:00:00