Abstract:
:Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. Mammary analogue secretory carcinoma's morphology is not entirely specific and overlaps with other salivary gland tumors. Documenting ETV6 rearrangement is confirmatory, but most laboratories are not equipped to perform this test. As mammary analogue secretory carcinomas are positive for mammaglobin, immunohistochemistry could potentially replace molecular testing as a confirmatory test, but the specificity of mammaglobin has not been evaluated across a large and diverse group of salivary gland tumors. One hundred thirty-one salivary gland neoplasms were evaluated by routine microscopy, mammaglobin immunohistochemistry, and ETV6 break-apart fluorescent in situ hybridization. The cases included 15 mammary analogue secretory carcinomas, 44 adenoid cystic carcinomas, 33 pleomorphic adenomas, 18 mucoepidermoid carcinomas, 10 acinic cell carcinomas, 4 adenocarcinomas not otherwise specified, 3 polymorphous low-grade adenocarcinomas, 3 salivary duct carcinomas, and 1 low-grade cribriform cystadenocarcinoma. All 15 mammary analogue secretory carcinomas harbored the ETV6 translocation and were strongly mammaglobin positive. None of the 116 other tumors carried the ETV6 translocation; however, mammaglobin staining was present in 1 (100%) of 1 low-grade cribriform cystadenocarcinoma, 2 (67%) of 3 polymorphous low-grade adenocarcinomas, 2 (67%) of 3 salivary duct carcinomas, 2 (11%) of 18 mucoepidermoid carcinomas, and 2 (6%) of 33 pleomorphic adenomas. Mammaglobin is highly sensitive for mammary analogue secretory carcinoma, but immunostaining can occur in a variety of tumors that do not harbor the ETV6 translocation. Strategic use of mammaglobin immunostaining has a role in the differential diagnosis of salivary gland neoplasms, but it should not be indiscriminately used as a confirmatory test for mammary analogue secretory carcinoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Bishop JA,Yonescu R,Batista D,Begum S,Eisele DW,Westra WHdoi
10.1016/j.humpath.2013.03.017subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1982-8issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(13)00147-0journal_volume
44pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.12.011
更新日期:2011-10-01 00:00:00
abstract::We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.030
更新日期:2017-01-01 00:00:00
abstract::Three cases of giant cell carcinoma of lung and six other lung carcinomas with large atypical cell formation were studied by both light and electron microscopy. The giant cell carcinomas showed unique light and electron microscopic features, whereas large atypical cells from other lung carcinomas usually retained some...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80003-2
更新日期:1976-01-01 00:00:00
abstract::We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in a...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2020.02.005
更新日期:2020-04-01 00:00:00
abstract::There is considerable interest in the role of the human wart virus in the pathogenesis of squamous cell carcinoma. Mucosal wart virus infections may produce considerable epithelial atypia and have eventuated in carcinoma in "normal" individuals in some instances. The verruciform lesions of patients with epidermodyspla...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80108-6
更新日期:1981-02-01 00:00:00
abstract::Mesenchymal chondrosarcoma, a rare malignant round cell and hyaline cartilage tumor, is most commonly intraosseous but can occur in extraskeletal sites. We intensively observed the morphology and applied Sox9 (master regulator of chondrogenesis), beta-catenin (involved in bone formation, thought to inhibit chondrogene...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.006
更新日期:2010-05-01 00:00:00
abstract::Parakeratosis refers to incomplete maturation of epidermal keratinocytes, resulting in abnormal retention of nuclei in the stratum corneum. It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.005
更新日期:2011-12-01 00:00:00
abstract::Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.12
更新日期:2003-02-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90349-4
更新日期:1996-12-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is known to play an important role in breast cancer invasion and metastatic progression. However, the pattern of expression of EMT markers in the progression from in situ to invasive breast carcinoma is not clear. To investigate this, we performed immunohistochemical analyses of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.07.003
更新日期:2013-11-01 00:00:00
abstract::Sections of synovium from 393 operations on diseased joints were re-examined without knowledge of the clinical findings. Specimens were scored for each of 37 histopathologic features. Independently, patients were assigned to one of 10 diagnostic groups after review of all available clinical data. Computer analysis rev...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80141-4
更新日期:1981-04-01 00:00:00
abstract::Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.31476
更新日期:2002-02-01 00:00:00
abstract::We report two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp and associated with allergic fungal sinusitis (AFS). Curvularia lunata was cultured in one case and Curvularia senegalensis was cultured in the other. Based on these cases and a review of the literature, we discuss unusual ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(91)90106-y
更新日期:1991-12-01 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.018
更新日期:2018-12-01 00:00:00
abstract::Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90175-5
更新日期:1989-02-01 00:00:00
abstract::B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 subtypes with either somatically mutated or unmutated immunoglobulin heavy-chain variable region (IgVH) genes. A prognostic significance of the infiltration pattern in bone marrow trephine biopsy has been described before. The combined pattern analysis...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.016
更新日期:2006-09-01 00:00:00
abstract::Several techniques for diagnosing adenocarcinoma of the lung are commonly available, but the frequency of their use and diagnostic sensitivity may vary. Twenty cases of primary lung adenocarcinoma obtained at surgery were studied by the following four routine techniques: light microscopy (LM) using hematoxylin-eosin (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80005-4
更新日期:1988-08-01 00:00:00
abstract::We studied the histopathologic, immunohistochemical, and ultrastructural features of the extracellular matrix (ECM) in 20 immunologically defined large-cell lymphomas, including immunoblastic sarcoma of B cells (three patients), peripheral T cell lymphoma (five patients), large non-cleaved follicular center cell (FCC)...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90181-0
更新日期:1989-02-01 00:00:00
abstract::To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.07.013
更新日期:2003-12-01 00:00:00
abstract::Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of p...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.016
更新日期:2015-04-01 00:00:00
abstract::Fluorescence in situ hybridization, loss of heterozygosity testing, and comparative genomic hybridization have been used to detect NF2 gene alterations in both sporadic and neurofibromatosis type 2 (NF2)-associated central nervous system tumors. In this study, we performed chromogenic in situ hybridization (CISH) and ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.027
更新日期:2007-09-01 00:00:00
abstract::Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are di...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80025-7
更新日期:1977-05-01 00:00:00
abstract::A 60-year-old man developed a widely metastatic spindle cell neoplasm with admixed osteoclast-like giant cells indistinguishable from malignant giant cell tumor of soft parts. Autopsy revealed a bronchogenic sarcomatoid squamous cell carcinoma that was the primary source of the sarcomatoid metastases. The osteoclast-l...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80181-6
更新日期:1983-11-01 00:00:00
abstract::PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.07.023
更新日期:2015-12-01 00:00:00
abstract::Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.08.011
更新日期:2010-02-01 00:00:00
abstract::Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.11.018
更新日期:2008-08-01 00:00:00
abstract::The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90258-q
更新日期:1991-11-01 00:00:00
abstract::The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for carcinomas of the large intestine are reported herein. ...
journal_title:Human pathology
pub_type: 指南,杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Insulin-like growth factor-II messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is a biomarker whose expression has been found to be a negative prognostic factor in several neoplasms including ovarian clear cell carcinoma (CCC). In this study, we analyzed the frequency and clinicopathologic significance of IMP3 expres...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.12.003
更新日期:2013-08-01 00:00:00
abstract::Epidermal growth factor receptor is a transmembrane receptor involved in oncogenesis, including the development of glioblastoma. We studied the prognostic significance of epidermal growth factor receptor amplification as determined by fluorescence in situ hybridization, quantitative polymerase chain reaction, and prot...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.09.020
更新日期:2010-06-01 00:00:00