Abstract：
:Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Karnik T,Ozawa MG,Lefterova M,Luna-Fineman S,Alvarez E,Link M,Zehnder JL,Arber DA,Ohgami RSdoi
10.1016/j.humpath.2014.12.016subject
Has Abstractpub_date
2015-04-01 00:00:00pages
629-33issue
4eissn
0046-8177issn
1532-8392pii
S0046-8177(15)00030-1journal_volume
46pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carci...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.03.011
更新日期：2004-08-01 00:00:00
abstract：:Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma (HCC) with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated HCCs. In the current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.025
更新日期：2018-10-01 00:00:00
abstract：:We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique. A series of 90 cases of human breast carcinoma was ana...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90060-8
更新日期：1995-03-01 00:00:00
abstract：:Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90056-m
更新日期：1993-01-01 00:00:00
abstract：:Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.06.003
更新日期：2009-12-01 00:00:00
abstract：:Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a variant of anaplastic large cell lymphoma arising within seroma effusion associated with breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised World Health Organization classification. All ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.05.007
更新日期：2019-08-01 00:00:00
abstract：:Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.11.021
更新日期：2010-10-01 00:00:00
abstract：:PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.07.023
更新日期：2015-12-01 00:00:00
abstract：:The Ewing family of tumors (EFT) is characterized by high MIC2/CD99 expression and specific EWS/ETS gene rearrangements, resulting in different chimeric transcripts. Further division into peripheral primitive neuroectodermal tumors and Ewing's sarcoma is still debated and, in the absence of distinct morphological para...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90223-x
更新日期：1999-09-01 00:00:00
abstract：:Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.08.033
更新日期：2017-10-01 00:00:00
abstract：:The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(76)80040-8
更新日期：1976-05-01 00:00:00
abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2004.02.007
更新日期：2004-06-01 00:00:00
abstract：:In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.012
更新日期：2018-10-01 00:00:00
abstract：:Kidneys from 1864 necropsies performed in Brisbane, Australia, and from 397 necropsies performed in Christchurch, New Zealand, were examined macroscopically and microscopically. Three zonal and three focal patterns of renal medullary calcification were defined: (1) Outer medullary cortical calcification seen in hyperc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80057-3
更新日期：1976-07-01 00:00:00
abstract：:Grade Group (GG) 4 prostate cancer includes Gleason scores (GS) 3 + 5 = 8, 4 + 4 = 8, and 5 + 3 = 8. Some studies without pathology re-review of historical cohorts proposed that the presence of pattern 5 worsens prognosis compared to GS 4 + 4 = 8 cancer. We assessed how often historically graded GS 5 + 3 = 8 cancers r...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2019.11.002
更新日期：2020-03-01 00:00:00
abstract：:Studies on melanoma cell lines indicate the expression of actin-binding protein (ABP), a peripheral cytoplasmic protein that crosslinks actin, is important for melanoma cell motility. We used an ABP-specific monoclonal antibody to characterize ABP expression in 18 benign nevi and 28 primary and metastatic malignant me...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90305-0
更新日期：1994-07-01 00:00:00
abstract：:A young male with Buerger's disease who had previously required a left leg amputation died in renal failure and sepsis. Postmortem examination revealed an obliterative lesion of the celiac artery, which resulted in hepatic, splenic, and pancreatic infarctions. Celiac artery involvement represents an unusual manifestat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80080-5
更新日期：1979-01-01 00:00:00
abstract：:Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.05.016
更新日期：2014-09-01 00:00:00
abstract：:Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides. Each showed diffuse staining for NSE. Most tumors were positive for [Leu5]-enkephalin (76 per cent), [Met5]-enk...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80314-9
更新日期：1988-01-01 00:00:00
abstract：:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.006
更新日期：2004-01-01 00:00:00
abstract：:Tumor budding is an acknowledged prognostic marker in colorectal cancer. This study was conducted to investigate the morphology and prognostic significance of budding in rectal cancer after neoadjuvant radiotherapy. Surgical specimens from 96 consecutive patients who underwent neoadjuvant radiotherapy and curative res...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.07.026
更新日期：2012-07-01 00:00:00
abstract：:The drs gene was originally isolated from a rat primary embryo fibroblast cDNA library as a suppressor gene against v-src transformation. We have previously shown that expression of drs mRNA was markedly reduced in a variety of human cancer cell lines, including those of the colon, bladder, and ovary. Furthermore, int...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125373
更新日期：2002-06-01 00:00:00
abstract：:Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.05.026
更新日期：2015-10-01 00:00:00
abstract：:Twenty-five cases of Crohn's disease confined to the appendix were reported in eight hospitals in Israel during a 15-year period. Review of the histologic slides confirmed the diagnosis in 22 cases. Re-evaluation of these 22 patients included physical examination and radiologic studies of the small and large bowel. Re...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80416-6
更新日期：1986-11-01 00:00:00
abstract：:Rosette-forming glioneuronal tumors of the fourth ventricle are rare brain tumors, and only 19 such lesions have been previously reported. This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord. A 44-year-old woman presented with a 15-year history of dissociated senso...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.11.010
更新日期：2009-06-01 00:00:00
abstract：:Endometrial carcinoma is the most common invasive malignancy of the female genital tract, and it exists as two different clinicopathologic forms: an estrogen-dependent, "usual" type and an estrogen-independent "special variant" type. Despite the frequency of endometrial cancer, little is known about the molecular gene...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90084-8
更新日期：1997-05-01 00:00:00
abstract：:Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors. The present study was undertaken to determine the usefulness of the Ki-67 index and the corresponding tumor grade in predicting progression-free surviv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.06.011
更新日期：2012-04-01 00:00:00
abstract：:A 33-year-old male runner, who had undergone a Swanson silastic prosthetic implant for degenerative joint disease of the first metatarsal head and proximal phalanx of the right great toe, presented with unilateral inguinal lymphadenopathy. Biopsy revealed confluent, non-caseating granulomas containing silastic materia...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80158-8
更新日期：1988-10-01 00:00:00
abstract：:Trefoil factors are wound-healing peptides important in protection and healing of the human gastrointestinal tract. Their potential for therapy of gastrointestinal ulcers has been established. This study investigated the hypothesis that trefoil factors are also present in human salivary gland. Tissues from surgical bi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hp.2000.6549
更新日期：2000-04-01 00:00:00
abstract：:Although the term "thyroiditis" suggests inflammation, many disorders of the thyroid that are of unknown etiology are also currently included under this heading. Thus, only infective thyroiditis and subacute thyroiditis are clearly inflammatory; autoimmune thyroiditis is a result of lymphocytic and fibroblastic infilt...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80028-8
更新日期：1978-07-01 00:00:00
