Abstract：
:Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we studied by immunohistochemistry 88 cases of GCTs and found that 51% of the samples expressed ER. Furthermore, we found that a subset of seven samples analyzed for ER expression by western blot was positive. To address whether the ER expressed in these samples could be functional, isolated cells were exposed to beta-estradiol and growth curves were generated. Exposure of cells to beta-estradiol induced a small but significant growth in the cells. These results strongly support that GCTs of the bone express functional ERs.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Olivera P,Perez E,Ortega A,Terual R,Gomes C,Moreno LF,Dueñas A,De La Garza J,Melendez-Zajgla J,Maldonado Vdoi
10.1053/hupa.2002.31476subject
Has Abstractpub_date
2002-02-01 00:00:00pages
165-9issue
2eissn
0046-8177issn
1532-8392pii
S0046817702007438journal_volume
33pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.05.025
更新日期：2011-02-01 00:00:00
abstract：:Viruses and other possible causative agents should be sought light and electron microscopically in all cases of ill-defined diseases including "sarcoid." Ideally, tissue should be prepared for electron microscopic examination as soon as a specimen is obtained; however, when this has not been done, tissue preserved in ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(83)80164-6
更新日期：1983-10-01 00:00:00
abstract：:The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.07.016
更新日期：2005-10-01 00:00:00
abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90185-4
更新日期：1997-06-01 00:00:00
abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90303-9
更新日期：1999-01-01 00:00:00
abstract：:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis; however, the clinical outcome remains heterogeneous. We sought to further stratify this subentity of AML by performing a retrospective analysis of 179 adult patients with AML-MRC diagnosed at our institution. Based o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.08.003
更新日期：2020-10-01 00:00:00
abstract：:To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.24997
更新日期：2001-06-01 00:00:00
abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.03.007
更新日期：2017-06-01 00:00:00
abstract：:The radiosensitivities of lymphocytes of peripheral blood origin obtained from two healthy 45 year old male donors were studied simultaneously at yearly intervals over a three year period. Hypaque-Ficoll purified cells were exposed in vitro to 0, 5, 50, and 500 rads and then evaluated serially for viability of T and B...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80007-6
更新日期：1979-03-01 00:00:00
abstract：:Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression levels. The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and expressionally altered in gastric (GC) and colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.013
更新日期：2014-08-01 00:00:00
abstract：:Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90041-m
更新日期：1991-02-01 00:00:00
abstract：:Gene expression studies have identified a basal phenotype of breast cancer; these are hormone receptor and HER2-negative cancers with poor prognosis. High levels of cyclin E and Skp2, and low levels of p27 have previously been individually associated with both basal-like breast cancer and a poor outcome after diagnosi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.03.004
更新日期：2008-10-01 00:00:00
abstract：:In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.11.012
更新日期：2016-04-01 00:00:00
abstract：:The reliability of a diagnostic test depends on the reproducibility of the result. Many clinical diagnostic tests can be quantified with established ranges and standard deviations. Other tests are more subjective, such as those that depend on analysis of a visual image with an increased possibility of variance in the ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(96)90157-4
更新日期：1996-06-01 00:00:00
abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lym...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.08.009
更新日期：2007-02-01 00:00:00
abstract：:A case of hemangiopericytoma arising in the esophagus is described. The light microscopic features were typical, and ultrastructural examination confirmed the presence of pericyte-like cells and excluded smooth muscle and fibroblastic differentiation. Areas of necrosis and a focus of mitotic activity within the tumor ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80248-1
更新日期：1981-01-01 00:00:00
abstract：:A digoxigenin-tailed, synthetic oligodeoxynucleotide was used to detect genomic hepatitis delta virus (HDV) RNA in formalin-fixed, paraffin-embedded liver sections by a nonisotopic in situ hybridization (NISH) procedure. Twenty-three liver samples from chronically HDV-infected patients were studied. Eight liver specim...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90133-n
更新日期：1992-05-01 00:00:00
abstract：:Posttransplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV), and may clinically resemble acute allograft rejection. Three methods to show EBV in tissue were evaluated in 15 liver allograft biopsies from 12 patients including four with PTLD: (1) semiquantitative polymerase chain react...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90074-5
更新日期：1997-05-01 00:00:00
abstract：:The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80107-4
更新日期：1981-02-01 00:00:00
abstract：:Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a h...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80254-3
更新日期：1984-11-01 00:00:00
abstract：:The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.11.022
更新日期：2019-04-01 00:00:00
abstract：:An unusual case of multiple myeloma in an 88-year-old patient is described. Besides skeletal involvement, there was myeloma of the thoracic and abdominal lymph nodes and of the liver and pancreas. In the pancreas, the myeloma extensively involved the head and body, and on computerized tomography scan was suggestive of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80057-9
更新日期：1982-10-01 00:00:00
abstract：:Fifty-three pure mucinous carcinomas of breast were studied, with long-term follow-up evaluation (average, 15 years) for 37. The mean age of the patients was 63 years. Long-term survival (Kaplan-Meier method) was 68 per cent, excluding non-tumor-related deaths. Median survival for the patients with fatal carcinomas wa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80152-6
更新日期：1986-01-01 00:00:00
abstract：:A 35-year-old white Jewish homosexual man who had undergone surgery and chemotherapy for an embryonal carcinoma of the testis subsequently developed Kaposi's sarcoma. The neoplasm involved the skin as well as visceral tissues. Tissue derived from a biopsy specimen of one of the skin lesions was used in the in situ hyb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80063-4
更新日期：1982-10-01 00:00:00
abstract：:We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.12.010
更新日期：2007-06-01 00:00:00
abstract：:Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7894
更新日期：2000-06-01 00:00:00
abstract：:Tumor cell adhesion, detachment, and aggregation play an important part in tumor invasion and metastasis, and a variety of cell adhesion molecules have been found on tumor cells. Cell adhesion molecules, including those of the immunoglobulin superfamily, are associated with the development of metastatic behavior in cu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90191-4
更新日期：1995-11-01 00:00:00
abstract：:Preeclampsia is a leading cause for maternal and perinatal mortality and morbidity. Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia. These studies deliver multiple pictures of gene signatures, implying the complicated pathophysiology. In the present wo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.002
更新日期：2014-06-01 00:00:00
abstract：:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age, 68 years; range, 34-87 y...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.11.004
更新日期：2012-09-01 00:00:00
abstract：:Geotrichum candidum was identified as an invasive organism in the terminal ileum of a man with "hairy cell" leukemia. The organism was identified on the basis of histologic and cultural characteristics. The diagnostic features of G. candidum infection are compared to those of Aspergillus and Candida species. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80055-x
更新日期：1981-07-01 00:00:00
