Abstract:
:Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a histopathologic study of this node was undertaken. The immature cells were identified as erythroblasts and pronormoblasts by histochemical staining (periodic acid-Schiff reagent and chloroacetate esterase), immunohistochemical reaction (directed against hemoglobin), and electron microscopy. The diagnosis of erythroleukemic lymph node infiltrate may be missed in the absence of a high index of suspicion. It is concluded that the detection of hemoglobin within malignant cells is most helpful in establishing the diagnosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Keifer J,Zaino R,Ballard JOdoi
10.1016/s0046-8177(84)80254-3subject
Has Abstractpub_date
1984-11-01 00:00:00pages
1090-3issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(84)80254-3journal_volume
15pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::FoxA1 regulates a variety of tissues during embryogenesis and early life. In thyroid, FoxA1 expression has recently been shown in C cells and medullary thyroid carcinomas but not in follicular cells. FoxA1 has also been proposed as a potential oncogene in anaplastic thyroid carcinomas. However, FoxA1 expression has no...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.05.007
更新日期:2017-07-01 00:00:00
abstract::NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.031
更新日期:2018-12-01 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.018
更新日期:2018-12-01 00:00:00
abstract::To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.10.012
更新日期:2006-02-01 00:00:00
abstract::CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.029
更新日期:2017-06-01 00:00:00
abstract::Fifty-three surgically resected small cell carcinomas of the lung were studied morphometrically, electron microscopically, immunohistochemically, and in terms of possible site of origin. Four subtypes of small cell carcinomas were identified: oat cell carcinoma (OAT), small cell carcinoma of the intermediate cell type...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80133-2
更新日期:1986-06-01 00:00:00
abstract::Intraductal papillary mucinous neoplasm is characterized by cystically dilated main and/or branch pancreatic duct with mucus. According to the degree of atypia, intraductal papillary mucinous neoplasm is classified into 3 groups: adenoma, borderline, and carcinoma. Furthermore, intraductal papillary mucinous neoplasm ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.019
更新日期:2010-11-01 00:00:00
abstract::Seminoma and sarcoidosis do not seem to be associated diseases, judging from epidemiologic data. The presence of these two diseases in the patient whose case is reported may have been coincidental. It was observed, however, that when the testis tumor appeared in this patient, the longstanding sarcoid lesions significa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80041-6
更新日期:1984-04-01 00:00:00
abstract::Three cases of giant cell carcinoma of lung and six other lung carcinomas with large atypical cell formation were studied by both light and electron microscopy. The giant cell carcinomas showed unique light and electron microscopic features, whereas large atypical cells from other lung carcinomas usually retained some...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80003-2
更新日期:1976-01-01 00:00:00
abstract::Papillary renal cell carcinoma (PRCC) is currently divided in 2 subtypes. We reviewed a large cohort of PRCC and correlated subtype, morphological features and diagnostic marker expression with overall survival (OS) to uncover differences between the 2 subtypes. Three hundred seventy-six renal tumors initially diagnos...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.006
更新日期:2019-01-01 00:00:00
abstract::Intraductal carcinoma of the prostate (IDC-P) and high-grade prostatic intraepithelial neoplasia (HGPIN) are two distinct intraductal lesions; the former is usually associated with invasive carcinoma and has an aggressive course while the latter is considered a precancerous lesion. In addition, there are morphological...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.03.011
更新日期:2014-08-01 00:00:00
abstract::We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90120-6
更新日期:1993-09-01 00:00:00
abstract::We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.030
更新日期:2017-01-01 00:00:00
abstract::Acute rejection is an extremely common complication of lung transplantation. (1) To appreciate the interobserver variation in the interpretation of histologic findings and (2) to assess the efficacy of transbronchial biopsy (TBB) for acute rejection diagnosis and associated diseases, particularly infection, we perform...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.01.022
更新日期:2005-04-01 00:00:00
abstract::Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.010
更新日期:2018-12-01 00:00:00
abstract::Malignant peripheral nerve sheath tumor is a malignant tumor showing nerve sheath differentiation. Approximately one-half of malignant peripheral nerve sheath tumors arise from a benign peripheral nerve sheath tumor, which is commonly a neurofibroma in patients with neurofibromatosis type 1. Malignant peripheral nerve...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.05.021
更新日期:2013-12-01 00:00:00
abstract::Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2015.06.013
更新日期:2015-09-01 00:00:00
abstract::Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.10.008
更新日期:2011-07-01 00:00:00
abstract::p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.06.014
更新日期:2017-08-01 00:00:00
abstract::To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.07.013
更新日期:2003-12-01 00:00:00
abstract::In two patients with malignant germ cell tumors angiosarcoma developed through two apparently different mechanisms. In one case the angiosarcoma probably developed as a complication of therapeutic radiation, since radiation changes were demonstrated in tissue adjacent to the neoplasm and since the angiosarcoma was not...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80013-7
更新日期:1985-03-01 00:00:00
abstract::Twenty-one childhood rhabdomyosarcomas were divided into three groups on the basis of cytologic composition. The tumors in group P consisted entirely of primitive mesenchymal cells, whereas those in groups M and W were characterized by the additional presence of numerous round rhabdomyoblasts and strap cells, respecti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80256-2
更新日期:1985-08-01 00:00:00
abstract::The aim of the current study was to test whether the grade group assessed in the index tumor nodule predicts biochemical recurrence after surgery. The study cohort series included 144 consecutive patients treated by laparoscopic radical prostatectomy. The following parameters were evaluated in each case: type of radic...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.08.012
更新日期:2019-11-01 00:00:00
abstract::Two extraskeletal myxoid chondrosarcomas were examined by electron microscopy. In addition to the well-described ultrastructural features indicative of chondroblastic origin, both of these chondrosarcomas had unusual parallel microtubules packed within rough endoplasmic reticulum. This paper reviews the differential d...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80036-3
更新日期:1986-05-01 00:00:00
abstract::We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.03.011
更新日期:2012-03-01 00:00:00
abstract::T-lymphocyte subsets in peripheral blood, bronchoalveolar lavage fluid, and prescalenic lymph nodes from eight patients with sarcoidosis were evaluated with monoclonal antibodies. Both in lung and lymph nodes significant increases in helper T cells were demonstrated, except in patients with stage III pulmonary disease...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80037-5
更新日期:1986-05-01 00:00:00
abstract::A distinctive ultrastructural finding, observed in a case of acute lymphoblastic leukemia (ALL) and previously unreported on the surface of bone marrow cells, is described. The alteration is referred to as distinctive cytoplasmic surface activity (DCSA). For further delineation, study of 130 consecutively submitted bo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80166-1
更新日期:1987-04-01 00:00:00
abstract::A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2020.03.007
更新日期:2020-05-01 00:00:00
abstract::The authors present 11 cases of plexiform neurofibroma (PN) that featured a very characteristic type of cell appearing as multivacuolated mucin-filled cells (MMFC). The 11 cases were obtained after reviewing 109 cases of PN. Six out of 10 patients showed clinical features of neurofibromatosis type 1. The size of PN ra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.10.010
更新日期:2017-02-01 00:00:00
abstract::Wild type p53 plays a crucial role in maintaining genomic stability in both normal and tumor cells in vitro. When DNA damage occurs, p53 acts as a cell cycle checkpoint and induces a cellular response that aims at restoring genomic integrity. p53 may either allow the repair of damaged DNA by inducing a transient G1 ar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90292-9
更新日期:1995-12-01 00:00:00