Abstract:
:To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (73.9%) of the 69 ACAs and 11 (68.7%) of the 16 AIS lesions. Prohibitin 1 overexpression was significantly higher in ACA and AIS than in adjacent nonneoplastic glandular epithelium (P < .001 for both comparisons). Prohibitin 1 expression was also positively related to tumor size (P = .019) or parametrial involvement (P = .027) in ACA. c-Met was expressed in 21 ACAs (30.4%) and was positively correlated with the Fédération Internationale de Gynécologie et d'Obstétrique (International Federation of Gynecology and Obstetrics) stage classification (P = .007) or nodal metastasis (P = .047). Nodal metastasis (P = .028) and c-Met expression (P = .022) were independent predictors for the overall survival of patients in multivariate analysis using the Cox regression method. Prohibitin 1 activation seems to be an early event, whereas c-Met overexpression may be important for the progression of cervical adenocarcinomas. Evaluation of c-Met expression status may identify a subset of patients with cervical adenocarcinoma who require more intensive treatment.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Tsai HW,Chow NH,Lin CP,Chan SH,Chou CY,Ho CLdoi
10.1016/j.humpath.2005.10.012subject
Has Abstractpub_date
2006-02-01 00:00:00pages
198-204issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(05)00604-0journal_volume
37pub_type
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