Subtypes of small cell carcinoma of the lung: morphometric, ultrastructural, and immunohistochemical analyses.

abstract：:Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...

journal_title：Human pathology

authors： Guilmette J,Dias-Santagata D,Nosé V,Lennerz JK,Sadow PM

更新日期：2019-01-01 00:00:00

abstract：:We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...

journal_title：Human pathology

authors： Deligdisch L,Kerner H,Cohen CJ,Dargent D,Gil J

更新日期：1993-02-01 00:00:00

abstract：:Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...

journal_title：Human pathology

authors： Häusler M,Schaade L,Ramaekers VT,Doenges M,Heimann G,Sellhaus B

更新日期：2003-03-01 00:00:00

abstract：:Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...

journal_title：Human pathology

authors： Bruch JF,Sibony O,Benali K,Challier JC,Blot P,Nessmann C

更新日期：1997-10-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer. Studies on Western and Japanese lung cancers have indicated substantial differences in the EGFR mutation frequency between these populations. To investigate the prev...

journal_title：Human pathology

authors： Al-Kuraya K,Siraj AK,Bavi P,Al-Jommah N,Ezzat A,Sheikh S,Amr S,Al-Dayel F,Simon R,Guido S

更新日期：2006-04-01 00:00:00

abstract：:Kearns-Sayre syndrome (KSS) and Pearson's marrow-pancreas syndrome (PMPS) are rare disorders caused by the same molecular defect, one of several deletion mutations in mitochondrial DNA (mtDNA). KSS is an encephalomyopathy with ophthalmoplegia, retinal degeneration, ataxia, and endocrine abnormalities. PMPS is a disord...

journal_title：Human pathology

authors： Becher MW,Wills ML,Noll WW,Hurko O,Price DL

更新日期：1999-05-01 00:00:00

abstract：:Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted t...

journal_title：Human pathology

authors： Silva Amancio AM,Cunha IW,Neves JI,Quetz JD,Carraro DM,Rocha RM,Zequi SC,Cubilla AL,da Fonseca FP,Lopes A,Cunha MD,Lima MV,Vassallo J,Guimarães GC,Soares FA

更新日期：2017-03-01 00:00:00

abstract：:Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...

journal_title：Human pathology

authors： Haupt B,Schwartz MR,Xu Q,Ro JY

更新日期：2010-06-01 00:00:00

abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...

journal_title：Human pathology

authors： Pradhan D,Schoedel K,McGough RL,Ranganathan S,Rao UNM

更新日期：2018-01-01 00:00:00

abstract：:Although T-lineage large granular lymphocyte (LGL) leukemia has been described for over 20 years, many patients with this neoplasm go unrecognized. Chief among the difficulties in diagnosing this entity is that the morphologic features are nonspecific and that it is difficult to distinguish it from reactive processes....

journal_title：Human pathology

authors： Evans HL,Burks E,Viswanatha D,Larson RS

更新日期：2000-10-01 00:00:00

abstract：:Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...

journal_title：Human pathology

authors： Popović M,Dolenc-Strazar Z,Anzic J,Luzar B

更新日期：2004-10-01 00:00:00

abstract：:Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...

journal_title：Human pathology

authors： George TI,Jones CD,Zehnder JL,Warnke RA,Dorfman RF

更新日期：2003-02-01 00:00:00

abstract：:We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required t...

journal_title：Human pathology

authors： Furudoï A,Caumont C,Dutriaux C,Cappellen D,Goussot JF,Vergier B,Merlio C,Barberis C,Merlio JP,Gros A

更新日期：2016-02-01 00:00:00

abstract：:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...

journal_title：Human pathology

authors： Orsatti G,Greenberg PD,Rolfes DB,Ishak KG,Paronetto F

更新日期：1994-09-01 00:00:00

abstract：:Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen dep...

journal_title：Human pathology

authors： Katzenstein AL

更新日期：1985-10-01 00:00:00

abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...

journal_title：Human pathology

authors： Huo L,Sugimura J,Tretiakova MS,Patton KT,Gupta R,Popov B,Laskin WB,Yeldandi A,Teh BT,Yang XJ

更新日期：2005-03-01 00:00:00

abstract：:The aim of the current study was to test whether the grade group assessed in the index tumor nodule predicts biochemical recurrence after surgery. The study cohort series included 144 consecutive patients treated by laparoscopic radical prostatectomy. The following parameters were evaluated in each case: type of radic...

journal_title：Human pathology

authors： Vau N,Henriques V,Cheng L,Blanca A,Fonseca J,Montironi R,Cimadamore A,Lopez-Beltran A

更新日期：2019-11-01 00:00:00

abstract：:Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...

journal_title：Human pathology

authors： Hazelbag HM,Van den Broek LJ,Fleuren GJ,Taminiau AH,Hogendoorn PC

更新日期：1997-02-01 00:00:00

abstract：:Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...

journal_title：Human pathology

authors： Doss BJ,Jacques SM,Qureshi F,Ramirez NC,Lawrence WD

更新日期：1998-02-01 00:00:00

abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

journal_title：Human pathology

authors： Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

更新日期：2010-03-01 00:00:00

abstract：:It has been suggested that inferences about fetal karyotype can be made from examination of placental and decidual histology in early, spontaneous abortions (SABs). We assessed the reproducibility and predictive value of histologic features in 75 karyotyped, first trimester SABs; 32% (24 of 75) had normal male karyoty...

journal_title：Human pathology

authors： Genest DR,Roberts D,Boyd T,Bieber FR

更新日期：1995-02-01 00:00:00

abstract：:Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...

journal_title：Human pathology

authors： Jhuang JY,Chang ST,Weng SF,Pan ST,Chu PY,Hsieh PP,Wei CH,Chou SC,Koo CL,Chen CJ,Hsu JD,Chuang SS

更新日期：2015-02-01 00:00:00

abstract：:Four cases of clear cell lymphoma were studied by means of light and electron microscopy, enzyme-histochemistry, and E- and EAC-rosette formation. On light microscopic examination the tumors were seen to be composed mainly of round, oval, or slight irregular cells with water-clear, abundant cytoplasm. The neoplastic c...

journal_title：Human pathology

authors： Zhuang HG,Liang GZ,Li WC,Zhang YQ,Guo RZ,Liu SL,He NX

更新日期：1988-07-01 00:00:00

abstract：:Four human fetuses with the limb body wall malformation complex, also known as the amniotic band syndrome, were examined. Besides malformations of the body wall and the limb(s), anomalies of the internal organs were found in three fetuses, suggesting a disturbance of normal morphogenesis before the fifth week of devel...

journal_title：Human pathology

authors： Hartwig NG,Vermeij-Keers C,De Vries HE,Kagie M,Kragt H

更新日期：1989-11-01 00:00:00

abstract：:Sections of synovium from 393 operations on diseased joints were re-examined without knowledge of the clinical findings. Specimens were scored for each of 37 histopathologic features. Independently, patients were assigned to one of 10 diagnostic groups after review of all available clinical data. Computer analysis rev...

journal_title：Human pathology

authors： Cooper NS,Soren A,McEwen C,Rosenberger JL

更新日期：1981-04-01 00:00:00

abstract：:CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...

journal_title：Human pathology

authors： Shah SS,Wu TT,Torbenson MS,Chandan VS

更新日期：2017-06-01 00:00:00

abstract：:Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower...

journal_title：Human pathology

authors： Magro G,Righi A,Casorzo L,Antonietta T,Salvatorelli L,Kacerovská D,Kazakov D,Michal M

更新日期：2012-11-01 00:00:00

abstract：:The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...

journal_title：Human pathology

authors： Conde E,Suarez-Gauthier A,García-García E,Lopez-Rios F,Lopez-Encuentra A,García-Lujan R,Morente M,Sanchez-Verde L,Sanchez-Cespedes M

更新日期：2007-09-01 00:00:00

abstract：:Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...

journal_title：Human pathology

authors： Giltman L,Alderete M,Minkowitz S

更新日期：1977-11-01 00:00:00

abstract：:Atypical fibro-osseous lesions, usually in the proximal femur, are a common consultative diagnostic problem. This is due to the fact that they contain a variety of patterns individually reminiscent of fibrous dysplasia, fibroxanthoma (non-ossifying fibroma), myxofibroma, lipoma, cyst, bone infarct, Paget's disease, an...

journal_title：Human pathology

authors： Ragsdale BD

更新日期：1993-05-01 00:00:00