Diagnostic specificity of synovial lesions.

abstract：:The benign epithelial neoplasm liver cell adenoma is rare, especially in childhood. We report 2 such cases, 1 of which was associated with Prader-Willi syndrome. Differential diagnosis of the liver cell adenomas on the basis of histopathologic findings proved difficult and was based on the absence of cellular and nucl...

journal_title：Human pathology

authors： Takayasu H,Motoi T,Kanamori Y,Kitano Y,Nakanishi H,Tange T,Nakagawara A,Hashizume K

更新日期：2002-08-01 00:00:00

abstract：:Disruptions of the p16-CDK4/cyclin D1-pRb pathway (RB pathway) and the p14ARF-MDM2-p53 pathway (p53 pathway) are important mechanisms in the development of human malignancies. In this study, we investigated RB and p53 pathways in 46 epithelial ovarian cancers (EOCs). In the RB pathway, 16 (34.8%) of 46 cases had p16 g...

journal_title：Human pathology

authors： Hashiguchi Y,Tsuda H,Yamamoto K,Inoue T,Ishiko O,Ogita S

更新日期：2001-09-01 00:00:00

abstract：:CD44 is an integral membrane glycoprotein that is a principal receptor for hyaluronan and plays a role in cell-extracellular matrix interactions. Recent studies of melanomas in mouse models have suggested that increased CD44 expression by these tumors may relate to metastatic potential. Immunohistochemical expression ...

journal_title：Human pathology

authors： Leigh CJ,Palechek PL,Knutson JR,McCarthy JB,Cohen MB,Argenyi ZB

更新日期：1996-12-01 00:00:00

abstract：:Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...

journal_title：Human pathology

authors： Hori Y,Yamamoto H,Nozaki Y,Torisu T,Fujiwara M,Taguchi K,Nishiyama K,Nakamura S,Kitazono T,Oda Y

更新日期：2020-02-01 00:00:00

abstract：:This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...

journal_title：Human pathology

authors： Koeneman MM,van Lint FHM,van Kuijk SMJ,Smits LJM,Kooreman LFS,Kruitwagen RFPM,Kruse AJ

更新日期：2017-01-01 00:00:00

abstract：:Twenty-one childhood rhabdomyosarcomas were divided into three groups on the basis of cytologic composition. The tumors in group P consisted entirely of primitive mesenchymal cells, whereas those in groups M and W were characterized by the additional presence of numerous round rhabdomyoblasts and strap cells, respecti...

journal_title：Human pathology

authors： Molenaar WM,Oosterhuis JW,Oosterhuis AM,Ramaekers FC

更新日期：1985-08-01 00:00:00

abstract：:One hundred six liver biopsy specimens from 34 orthotopic liver transplant (OLT) patients were examined and the histologic findings correlated with the clinical course of the patients to determine if specific morphologic patterns were associated with specific causes of acute allograft dysfunction. The principle causes...

journal_title：Human pathology

authors： Ray RA,Lewin KJ,Colonna J,Goldstein LI,Busuttil RW

更新日期：1988-07-01 00:00:00

abstract：:The diagnosis of melanoma metastatic to lymph node remains a difficult problem given its histological diversity. We examined the staining patterns of S-100, NK1/C3, HMB-45, and MART-1 (DC10) in melanoma metastases to lymph nodes. Immunohistochemical stains were performed on tissue sections of 126 formalin-fixed lymph ...

journal_title：Human pathology

authors： Zubovits J,Buzney E,Yu L,Duncan LM

更新日期：2004-02-01 00:00:00

abstract：:Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression levels. The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and expressionally altered in gastric (GC) and colorectal ca...

journal_title：Human pathology

authors： Choi YJ,Oh HR,Choi MR,Gwak M,An CH,Chung YJ,Yoo NJ,Lee SH

更新日期：2014-08-01 00:00:00

abstract：:Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...

journal_title：Human pathology

authors： Baker PM,Young RH

更新日期：2000-06-01 00:00:00

abstract：:Clusterin has been reported to play a significant role in tumorigenesis, and its overexpression occurs in various human malignancies. We examine the clusterin overexpression in human hepatocellular carcinoma (HCC) and verify its clinical usefulness as a candidate biomarker by clinicopathologic and survival analysis. W...

journal_title：Human pathology

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2004-11-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...

journal_title：Human pathology

authors： Lee RG

更新日期：1989-06-01 00:00:00

abstract：:The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...

journal_title：Human pathology

authors： Conley FK,Jenkins KA,Remington JS

更新日期：1981-08-01 00:00:00

abstract：:We have previously shown that necrotic tumors retain their immunoreactivity for a range of cytokeratin antibodies. Some thyroid tumors undergo extensive necrosis after fine-needle aspiration (FNA) procedures. We evaluated the sensitivity of antibodies on necrotic thyroid tumors by examining a series of thyroid tumors ...

journal_title：Human pathology

authors： Judkins AR,Roberts SA,Livolsi VA

更新日期：1999-11-01 00:00:00

abstract：:To determine useful factors when selecting an appropriate procedure for noninvasive ampullary neoplasia, we investigated the relationship between the location and the histomorphological/immunohistochemical characteristics of 56 noninvasive ampullary neoplasms obtained by endoscopic papillectomy (EP). All subjects were...

journal_title：Human pathology

authors： Yamamoto Y,Nemoto T,Okubo Y,Nihonyanagi Y,Ishiwatari T,Takuma K,Tochigi N,Okano N,Wakayama M,Igarashi Y,Shibuya K

更新日期：2014-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a commonly occurring tumor in southern China. Although several causative factors have now been recognized, the genetic basis underlying its tumorigenesis is still unclear. To identify potential chromosomal aberrations for further investigations, comparative genomic hybridization (CGH)...

journal_title：Human pathology

authors： Fan CS,Wong N,Leung SF,To KF,Lo KW,Lee SW,Mok TS,Johnson PJ,Huang DP

更新日期：2000-02-01 00:00:00

abstract：:A comparative study of the immunohistochemical (Stem cell leukemia/T-cell acute leukemia [SCL/TAL-1] protein expression) and genotypic (deletions in the SCL/tal-1 gene) findings in T-acute lymphoblastic leukemia (T-ALL) is presented. Formalin-fixed tissue from 50 cases of T-ALL were stained with a novel monoclonal ant...

journal_title：Human pathology

authors： Chetty R,Pulford K,Jones M,Mathieu-Mahul D,Close P,Hussein S,Pallesen G,Ralfkiaer E,Stein H,Gatter K

更新日期：1995-09-01 00:00:00

abstract：:Nested urothelial carcinoma (UC) is a rare histologic variant of UC, characterized by deceptively bland histologic features resembling von Brunn's nests but usually with a poor outcome. In our experience, this variant is frequently misclassified or underrecognized as its clinicopathologic spectrum is not well defined....

journal_title：Human pathology

authors： Wasco MJ,Daignault S,Bradley D,Shah RB

更新日期：2010-02-01 00:00:00

abstract：:The surgical pathologist is often called upon to make a rapid decision about the malignant potential of a soft tissue tumor. These tumors have specific stromas that support growth and endow the tumor with unique qualities, as well as being manifestations of the phenotypic expression of tumor cells. Collagen, the major...

journal_title：Human pathology

authors： Stern R

更新日期：1981-09-01 00:00:00

abstract：:Diffuse gastric cancer, characterized by poorly cohesive, diffusely infiltrating cells with no or little gland formation, is known to show several morphologic variants, but their prognostic value, if any, is poorly documented. In this article, 119 cases of invasive (T1b to T4) diffuse gastric cancer, which had undergo...

journal_title：Human pathology

authors： Chiaravalli AM,Klersy C,Tava F,Manca R,Fiocca R,Capella C,Solcia E

更新日期：2009-11-01 00:00:00

abstract：:Endothelial cell injury may contribute to the progression of various glomerular diseases. In the present study, we examined glomerular capillary injury in acute and chronic glomerular lesions in patients with Immunoglobulin A nephropathy (IgAN). We selected renal biopsy samples of IgAN (n = 200), and glomerular capill...

journal_title：Human pathology

authors： Kusano T,Takano H,Kang D,Nagahama K,Aoki M,Morita M,Kaneko T,Tsuruoka S,Shimizu A

更新日期：2016-03-01 00:00:00

abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...

journal_title：Human pathology

authors： Subramaniam MM,Piqueras M,Navarro S,Noguera R

更新日期：2009-11-01 00:00:00

abstract：:Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...

journal_title：Human pathology

authors： Zirkin HJ,Levy J,Katchko L

更新日期：1996-09-01 00:00:00

abstract：:Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marr...

journal_title：Human pathology

authors： Osborne BM,Guarda LA,Butler JJ

更新日期：1984-11-01 00:00:00

abstract：:We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; ...

journal_title：Human pathology

authors： Knowles DM,Wolff M

更新日期：1976-09-01 00:00:00

abstract：:Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in breast cancers. An archive of 322 formalin-fixed and paraffin-embedded ...

journal_title：Human pathology

authors： Ooi A,Inokuchi M,Horike SI,Kawashima H,Ishikawa S,Ikeda H,Nakamura R,Oyama T,Dobashi Y

更新日期：2019-03-01 00:00:00

abstract：:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...

journal_title：Human pathology

authors： Silver MM,Vilos GA,Silver MD,Shaheed WS,Turner KL

更新日期：1984-12-01 00:00:00

abstract：:DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze DNA methyltransferase expression by immunohistochemistry in a series of 94 Tunisian sporadic breast carcinomas. Re...

journal_title：Human pathology

authors： Ben Gacem R,Hachana M,Ziadi S,Ben Abdelkarim S,Hidar S,Trimeche M

更新日期：2012-10-01 00:00:00

abstract：:Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...

journal_title：Human pathology

authors： Yokoi T,Mark EJ

更新日期：1991-07-01 00:00:00

abstract：:Four surgically resected cardiac valves received from three female patients showed the presence of acute and chronic rheumatic valvulitis. The material was studied by means of transmission and scanning electron microscopy. This is the first time that there has been an investigation of the ultrastructure in acute rheum...

journal_title：Human pathology

authors： Siew S

更新日期：1980-01-01 00:00:00