Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells.

abstract：:Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...

journal_title：Human pathology

authors： Conces MR,Williamson SR,Montironi R,Lopez-Beltran A,Scarpelli M,Cheng L

更新日期：2012-09-01 00:00:00

abstract：:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...

journal_title：Human pathology

authors： Schwarz J,Ayim A,Schmidt A,Jäger S,Koch S,Baumann R,Dünne AA,Moll R

更新日期：2006-05-01 00:00:00

abstract：:Cystic hygroma of the neck was observed in seven spontaneously aborted, severely autolyzed female fetuses. Four of five karyotyped cases had the 45,XO karyotype; one was a normal female, 46,XX. Diagnostic features associated with monosomy X in fetuses, which were observed in six of these cases, include large cystic hy...

journal_title：Human pathology

authors： Byrne J,Blanc WA,Warburton D,Wigger J

更新日期：1984-01-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas an...

journal_title：Human pathology

authors： Chong EY,Lam PY,Poon WS,Ng HK

更新日期：1998-06-01 00:00:00

abstract：:Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal ant...

journal_title：Human pathology

authors： Grignon DJ,Ro JY,Ordoñez NG,Ayala AG,Cleary KR

更新日期：1988-12-01 00:00:00

abstract：:Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....

journal_title：Human pathology

authors： Margraf LR,Paciga JE,Balis JU

更新日期：1990-04-01 00:00:00

abstract：:Anaplastic meningiomas (MIIIs) and meningeal hemangiopericytomas (HPCs) display significant morphologic and immunohistochemical overlap, including occasional cases of otherwise classic HPC with focal epithelial membrane antigen (EMA) positivity. The availability of several new biomarkers prompted us to examine the pot...

journal_title：Human pathology

authors： Rajaram V,Brat DJ,Perry A

更新日期：2004-11-01 00:00:00

abstract：:Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...

journal_title：Human pathology

authors： Yarom R,Carmy O,Robin GC,More R

更新日期：1981-07-01 00:00:00

abstract：:Intrasinusoidal infiltration of bone marrow (BM) may accompany several malignant lymphoproliferative disorders. In small B-cell lymphomas, this pattern is considered specific for splenic marginal zone lymphoma (SMZL) when exclusive or prominent, although it may occur in other subtypes of non-Hodgkin's lymphomas (NHLs)...

journal_title：Human pathology

authors： Schenka AA,Gascoyne RD,Duchayne E,Delsol G,Brousset P

更新日期：2003-08-01 00:00:00

abstract：:The evolution of sequential histological changes from normal cells through invasive cancer affords the cancer biologist the opportunity to identify separate molecular steps involved in cancer progression. As one studies the development of human carcinoma, it becomes apparent that multiple genetic alterations affecting...

journal_title：Human pathology

authors： Stemmermann G,Heffelfinger SC,Noffsinger A,Hui YZ,Miller MA,Fenoglio-Preiser CM

更新日期：1994-10-01 00:00:00

abstract：:To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For ...

journal_title：Human pathology

authors： Lee MC,Kim GM,Woo YJ,Kim MK,Kim JH,Nam SC,Suh JJ,Chung WK,Lee JS,Kim HI,Choi HY,Kim SU

更新日期：2001-06-01 00:00:00

abstract：:Endolymphatic sac tumor (ELST) is a low-grade adenocarcinoma of the temporal bone that is presumed to originate from the endolymphatic system. Although ELSTs are extremely rare in the general population, a significant number of studies have documented the occurrence of ELST among patients with von Hippel-Lindau (VHL) ...

journal_title：Human pathology

authors： Hamazaki S,Yoshida M,Yao M,Nagashima Y,Taguchi K,Nakashima H,Okada S

更新日期：2001-11-01 00:00:00

abstract：:Pancreatic cancer (PaCA) is a deadly disease with few systemic therapeutic options. The head of the pancreas is the most innervated part and most common location of cancer. However, little is known about the contribution of the nerve-cancer interaction to facilitate pancreatic progression. To quantify PaCA axonogenesi...

journal_title：Human pathology

authors： He D,Manzoni A,Florentin D,Fisher W,Ding Y,Lee M,Ayala G

更新日期：2016-06-01 00:00:00

abstract：:Cytochrome P-450 specific for steroid 17 alpha-hydroxylation (P-45017 alpha) was immunolocalized in normal and hyperfunctioning adrenal glands of pigs, bovines, and humans, using a specific IgG fraction raised against the enzyme. P-45017 alpha was present in the zona fasciculata (ZF) and zona reticularis (ZR), but not...

journal_title：Human pathology

authors： Sasano H,Mason JI,Sasano N

更新日期：1989-02-01 00:00:00

abstract：:The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...

journal_title：Human pathology

authors： Fine G,Raju U

更新日期：1987-08-01 00:00:00

abstract：:Insulin-like growth factor II messenger RNA (mRNA)-binding protein 3 (IMP3) is an oncofetal protein that promotes tumor progression and metastasis in a number of malignancies. However, the clinical significance of IMP3 expression in squamous cell carcinoma (SCC) of the uterine cervix is unclear. In this study, the cor...

journal_title：Human pathology

authors： Wei Q,Yan J,Fu B,Liu J,Zhong L,Yang Q,Zhao T

更新日期：2014-11-01 00:00:00

abstract：:We report three cases of follicular dendritic cell sarcoma (FDCS) showing a hitherto undescribed histological pattern consisting of nodular tumor growth associated with small B lymphocytes. FDCS tumor cells consistently showed large epithelioid features and were intermingled with small lymphocytes in the nodules in tw...

journal_title：Human pathology

authors： Lorenzi L,Lonardi S,Petrilli G,Tanda F,Bella M,Laurino L,Rossi G,Facchetti F

更新日期：2012-02-01 00:00:00

abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...

journal_title：Human pathology

authors： Subramaniam MM,Piqueras M,Navarro S,Noguera R

更新日期：2009-11-01 00:00:00

abstract：:The concurrent presence of JAK2 V617F, monocytosis, and bone marrow fibrosis can be observed in both chronic myelomonocytic leukemia (CMML) and primary myelofibrosis (PMF). It can be challenging to distinguish CMML with JAK2 mutation and fibrosis from other myeloid neoplasms, particularly PMF. To identify key features...

journal_title：Human pathology

authors： Hu Z,Ramos CEB,Medeiros LJ,Zhao C,Yin CC,Li S,Hu S,Wang W,Thakral B,Xu J,Verstovsek S,Lin P

更新日期：2019-03-01 00:00:00

abstract：:Neuronal intranuclear inclusion disease (NIID) is a progressive, usually fatal degenerative neurologic condition characterized by eosinophilic, intranuclear inclusions in neurons of the central and peripheral nervous system. We report a boy with onset of disease manifestations at age 3 and death at age 9, who showed c...

journal_title：Human pathology

authors： Oyer CE,Cortez S,O'Shea P,Popovic M

更新日期：1991-07-01 00:00:00

abstract：:Most histopathologic descriptions of influenza pneumonia are based on autopsy findings in fatal cases during epidemics and pandemics of influenza. We describe the histologic findings of influenza pneumonia observed in biopsy material derived from six sporadic cases of influenza (influenza A, four cases; influenza B, o...

journal_title：Human pathology

authors： Yeldandi AV,Colby TV

更新日期：1994-01-01 00:00:00

abstract：:Liver involvement in amyloidosis is rarely associated with intrahepatic cholestasis. The cases recorded in the literature indicate that there is a tendency toward periportal deposition, leading to centrilobular cholestasis. Our case was most interesting in that the amyloid deposition was most severe in the centrilobul...

journal_title：Human pathology

authors： Finkelstein SD,Fornasier VL,Pruzanski W

更新日期：1981-05-01 00:00:00

abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...

journal_title：Human pathology

authors： Karpowicz MK,Shalmon B,Molberg KH,El-Naggar AK

更新日期：2011-09-01 00:00:00

abstract：:The pathology report is a critical document that helps guide the management of patients with cancer. More and more patients read their reports, intending to participate in decisions about their care. However, a substantial subset of patients may lack the ability to comprehend this often technical and complex document....

journal_title：Human pathology

authors： Mossanen M,True LD,Wright JL,Vakar-Lopez F,Lavallee D,Gore JL

更新日期：2014-11-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its...

journal_title：Human pathology

authors： Haffner MC,Kronberger IE,Ross JS,Sheehan CE,Zitt M,Mühlmann G,Ofner D,Zelger B,Ensinger C,Yang XJ,Geley S,Margreiter R,Bander NH

更新日期：2009-12-01 00:00:00

abstract：:Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin i...

journal_title：Human pathology

authors： Said S,Kurtin PJ,Nasr SH,Graham RP,Dasari S,Vrana JA,Yasir S,Torbenson MS,Zhang L,Mounajjed T,Eric Chen ZM,Lee HE,Wu TT

更新日期：2020-09-01 00:00:00

abstract：:AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...

journal_title：Human pathology

authors： Wang R,Yu Z,Chen F,Liao C,Wang Q,Huang X

更新日期：2018-03-01 00:00:00

abstract：:Gene hypomethylation and hypermethylation can lead to a loss of genetic imprinting in malignancies. The mechanism responsible for overexpression of the imprinted insulin-like growth factor II (IGF2) gene has not been investigated in osteosarcoma. In this study, the expression levels, imprinting status, and the extent ...

journal_title：Human pathology

authors： Li Y,Meng G,Huang L,Guo QN

更新日期：2009-10-01 00:00:00

abstract：:Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...

journal_title：Human pathology

authors： Espinosa I,D'Angelo E,Corominas M,Gonzalez A,Prat J

更新日期：2018-01-01 00:00:00

abstract：:Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors. The present study was undertaken to determine the usefulness of the Ki-67 index and the corresponding tumor grade in predicting progression-free surviv...

journal_title：Human pathology

authors： Dhall D,Mertens R,Bresee C,Parakh R,Wang HL,Li M,Dhall G,Colquhoun SD,Ines D,Chung F,Yu R,Nissen NN,Wolin E

更新日期：2012-04-01 00:00:00