Abstract：
:In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survival rate in contrast to patients with KRAS mutations that are associated with virtually no response tyrosine-kinase inhibitors. In this study, we have investigated EGFR and KRAS mutations in metastatic lung adenocarcinoma. Using Johns Hopkins Hospital archives, 1966 lung adenocarcinomas were found from January 2007 to May 2010. A total of 60 metastatic adenocarcinomas (28 cytologic and 32 surgical cases) with EGFR and KRAS studies were identified. In addition, 18 cases of primary and matched metastases were also included. Exons 18 to 21 of EGFR and exon 2 of KRAS (codons 12 and 13) were sequenced. In our study, EGFR and KRAS mutations were found in 21.7% (13 of 60 cases) and 28.3% (17 of 60 cases), respectively, and occurred more often with advanced stage of primary tumors. KRAS mutations were associated with poor prognosis and occurred exclusively in smokers in comparison with EGFR mutation. Of 9 pairs, mutations were concordant in 77.8%; 1 pair displayed acquisition of KRAS mutation, whereas 1 pair showed loss of EGFR mutation in the corresponding metastasis. Our findings suggest that EGFR and KRAS status should be tested in metastasis regardless of known mutations of the primary tumor. Additional studies are needed to further investigate the mechanisms of discordances in metastatic tumors.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Munfus-McCray D,Harada S,Adams C,Askin F,Clark D,Gabrielson E,Li QKdoi
10.1016/j.humpath.2010.12.011subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1447-53issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(11)00022-0journal_volume
42pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80079-9
更新日期：1984-05-01 00:00:00
abstract：:Preeclampsia is a leading cause for maternal and perinatal mortality and morbidity. Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia. These studies deliver multiple pictures of gene signatures, implying the complicated pathophysiology. In the present wo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.002
更新日期：2014-06-01 00:00:00
abstract：:A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80237-7
更新日期：1981-01-01 00:00:00
abstract：:Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma (HCC) with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated HCCs. In the current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.025
更新日期：2018-10-01 00:00:00
abstract：:Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.11.018
更新日期：2008-08-01 00:00:00
abstract：:To ensure appropriate mission-based budgeting and equitable distribution of funds for faculty salaries, our compensation committee developed a pathology-specific effort reporting database. Principles included the following: (1) measurement should be done by web-based databases; (2) most entry should be done by departm...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.10.033
更新日期：2008-04-01 00:00:00
abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90185-4
更新日期：1997-06-01 00:00:00
abstract：:Microsatellite instability (MSI) defines a specific type of genetic instability. Although consensus diagnostic criteria for MSI definition in colorectal cancer have been established, their utility in other tumor types remain to be proven. Previously we developed a mathematical model for MSI definition in colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.10.021
更新日期：2004-03-01 00:00:00
abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90226-0
更新日期：1995-07-01 00:00:00
abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.01.011
更新日期：2005-03-01 00:00:00
abstract：:Atrial fibrillation becomes a self-perpetuating arrhythmia as a consequence of electrophysiologic and structural remodeling involving the atrium. Oxidative stress may be a link between this rhythm disturbance and electrophysiologic remodeling. The aim of this study was to evaluate whether the heme oxygenase-1 (HO-1) m...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.007
更新日期：2008-08-01 00:00:00
abstract：:In a review of pediatric autopsies from 1951 to 1985, we identified 40 cases in which pancreatitis was diagnosed pathologically. Twenty-six of these patients were under 4 years of age, and the male-to-female ratio was 1.5. Six groups of patients were identified: 10 with hepatobiliary disease, including 9 with biliary ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80530-6
更新日期：1988-03-01 00:00:00
abstract：:Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, aft...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2017.05.010
更新日期：2017-09-01 00:00:00
abstract：:Metanephric stromal tumors (MSTs) are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors, along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.025
更新日期：2017-02-01 00:00:00
abstract：:The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.07.002
更新日期：2017-09-01 00:00:00
abstract：:The distinction of malignant mesothelioma from non-small-cell lung carcinoma (NSCLC) usually requires immunohistochemistry, but some broad-spectrum carcinoma markers stain mesotheliomas, and it remains unclear which broad-spectrum markers are most valuable for distinguishing these malignancies. Here, we directly compa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.04.005
更新日期：2020-06-01 00:00:00
abstract：:In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.012
更新日期：2018-10-01 00:00:00
abstract：:Giant cell tumor of tendon sheath (GCTTS) is a common soft tissue tumor. Immunophenotypical evidence suggests it is of synovial cell origin. There is controversy regarding the underlying nature of this lesion, specifically whether it is a neoplastic or nonneoplastic (ie, reactive or hyperplastic) process. Karyotypic a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90155-6
更新日期：1997-07-01 00:00:00
abstract：:Meconium-associated vascular necrosis (MAVN) is a histological abnormality of human placental chorionic vessels that is associated with poor neonatal outcome. We tested the hypothesis that MAVN shows apoptosis in the walls of chorionic vessels. Archival placental specimens with MAVN (n = 5) were compared with specimen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.12.002
更新日期：2004-04-01 00:00:00
abstract：:To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80005-6
更新日期：1976-01-01 00:00:00
abstract：:Spindle cell squamous esophageal carcinomas are distinctive polypoid "biphasic" tumors in which the sarcoma-like phenotype usually predominates over the epithelial component. To biologically assess both phenotypes, we compared the tumoral proliferative activity and DNA ploidy between the two histological components of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90458-0
更新日期：1998-08-01 00:00:00
abstract：:A 35-year-old white Jewish homosexual man who had undergone surgery and chemotherapy for an embryonal carcinoma of the testis subsequently developed Kaposi's sarcoma. The neoplasm involved the skin as well as visceral tissues. Tissue derived from a biopsy specimen of one of the skin lesions was used in the in situ hyb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80063-4
更新日期：1982-10-01 00:00:00
abstract：:A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.20411
更新日期：2000-12-01 00:00:00
abstract：:Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.01.019
更新日期：2015-05-01 00:00:00
abstract：:Aberrations of the long arm of chromosome 13 are common in prostate cancer and were initially attributed to alterations of the RB1 gene in band q14 of the chromosome. However, prostate tumors generally yield normal p110RB1 nuclear staining despite loss of heterozygosity (LOH) at the RB1 locus. Our previous analysis of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90142-9
更新日期：1999-07-01 00:00:00
abstract：:The DNA content of both fresh and formalin-fixed, paraffin-embedded tissues from 30 solid neoplasms was analyzed by flow cytometry. Cells from a single paraffin block of each tumor were disaggregated according to the method of Hedley et al. Cells were sampled from multiple sites of each fresh specimen. Fresh and depar...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80521-5
更新日期：1988-03-01 00:00:00
abstract：:We report the case of an exuberant ulcerative angiomatoid nasal lesion in a cocaine abuser. The lesion was made up of polymorphous endothelial cells with occasional mitoses, arranged in a lobular pattern with infiltrative-looking areas. There were extensive areas of thrombosis with focal recanalization. Intravascular ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80226-9
更新日期：2000-02-01 00:00:00
abstract：:The genetic diagnosis of Gaucher disease by molecular methods is complicated by the existence of a highly homologous transcribed pseudogene (96% identity) that is found in close proximity to the true gene on chromosome 1q21. In addition, the pseudogene sequence can mimic disease-causing mutations in the true gene. Sel...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.11.006
更新日期：2004-04-01 00:00:00
abstract：:The presence and morphology of high-grade prostatic intraepithelial neoplasia (H-PIN) was blindly evaluated in 40 totally embedded radical prostatectomy specimens of patients with prostate cancer randomized to either a 3 (n = 18) or 6 months (n = 22) combined androgen blockade regimen before surgery. In 5 cases, neo-a...
journal_title：Human pathology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0046-8177(99)90174-0
更新日期：1999-12-01 00:00:00
abstract：:The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90340-9
更新日期：1992-07-01 00:00:00
