Abstract:
:In the past decade most studies of coronary arterial aneurysms have been clinical; few have focused on morphology and etiopathogenesis. The subjects of the present autopsy study were 52 patients, 5 months to 80 years of age, with coronary arterial aneurysms. Patients were divided into two groups: 38 with atherosclerotic coronary aneurysms and 14 with aneurysms secondary to inflammation. Of the 38 patients with atherosclerotic aneurysms, 20 (53 per cent) had histories of ischemic heart disease; the aneurysms were in the right coronary artery in 18 (47 per cent), the left coronary artery in 13 (35 per cent), and in the right and left coronary arteries in seven (18 per cent). Of the four major coronary arteries, the average number of severely narrowed arteries (reduction of more than 75 per cent) in cross-sectional luminal area) was 1.8/patient; aortic aneurysms were present in eight of these patients (24 per cent). Of the 14 patients with coronary aneurysms secondary to inflammation, four had histories of ischemic heart disease; 10 had histories of an influenza-like syndrome. Isolated left coronary arterial aneurysms were seen in six of these patients (43 per cent), while eight (51 per cent) had multiple right and left coronary arterial aneurysms. The average number of severely narrowed coronary arteries in this group was 1.5/patient, and only one patient had an aortic aneurysm. Therefore, patients with atherosclerotic aneurysms are more often symptomatic; they have increased heart weights and equal numbers of coronary arterial aneurysms in the right and left vessels, and the majority (89 per cent) have single aneurysms with thrombi in the lumen. Patients with coronary arterial aneurysms secondary to inflammation are younger; the majority of these patients have a prodromal influenza-like syndrome, a low incidence of ischemic heart disease, and multiple coronary arterial aneurysms.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Virmani R,Robinowitz M,Atkinson JB,Forman MB,Silver MD,McAllister HAdoi
10.1016/s0046-8177(86)80129-0subject
Has Abstractpub_date
1986-06-01 00:00:00pages
575-83issue
6eissn
0046-8177issn
1532-8392pii
S0046-8177(86)80129-0journal_volume
17pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90200-o
更新日期:1990-04-01 00:00:00
abstract::This study tested whether concordance could be achieved for abnormal inflammation in the basal decidua of placental specimens among 6 pathologists experienced in placental pathology. Thirty microscope slides were evaluated by the pathologists for chronic deciduitis. They also scored the severity and extent of inflamma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80241-5
更新日期:2000-03-01 00:00:00
abstract::Lymphoepithelial cysts with histological features characteristic of branchial cleft cysts have been reported to occur rarely in the thyroid gland. To our knowledge only six cases of this lesion have been reported. Since these reports brought this entity to our attention, we have noted that intrathyroidal lymphoepithel...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90042-6
更新日期:1994-11-01 00:00:00
abstract::A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90199-x
更新日期:1998-09-01 00:00:00
abstract::This report describes a 47-year-old man with Erdheim-Chester disease (EC), the second case reported in Japan. The patient complained of knee pain, and the roentgenogram of the bilateral legs revealed symmetric osteolytic lesions with sclerosis of the metaphyseal regions of the long bones. Histological examination of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90145-8
更新日期:1996-01-01 00:00:00
abstract::Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.9086
更新日期:2000-08-01 00:00:00
abstract::In 1999, the World Health Organization (WHO) published a new classification of papillary urothelial tumors of the urinary bladder. Intended to represent a reproducible, easy-to-use classification system that better separates patients with true malignancies (bladder cancer) from those patients who are at an increased r...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.8224
更新日期:2000-06-01 00:00:00
abstract::Although the therapeutic outcome of osteosarcoma patients has improved dramatically within the last 20 years because of combined neoadjuvant chemotherapy and surgery, the problem of drug resistance remains. Thus far, markers that can predict the response to chemotherapy at the time of biopsy are not available. Heat sh...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90412-9
更新日期:1998-10-01 00:00:00
abstract::We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.025
更新日期:2016-02-01 00:00:00
abstract::In the present study the clinical and pathological evolution of a reactive-like B-cell lymphoproliferative disorder with an unusually high content of T cells is described. Immunogenotypic analysis showed that the same phenotypically atypical B-cell clone, characterized by the unusual presence of an immunoglobulin (Ig)...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90070-5
更新日期:1995-03-01 00:00:00
abstract::We reviewed open lung biopsies from 35 patients with Wegener's (pathergic) granulomatosis in order to study the histogenesis of the pulmonary lesions and to identify the early lesions. The process of pathergic necrosis is fundamental in the production of extravascular and vascular lesions and was divided into micronec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80088-1
更新日期:1988-09-01 00:00:00
abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90448-8
更新日期:1998-08-01 00:00:00
abstract::Spindle cell carcinoma (SpCC) is uncommon, with a predilection for the upper aerodigestive tract. Its histogenesis has not been resolved, although most authors support the sarcomatoid carcinoma concept. Ploidy analysis and proliferation indices have not been reported for laryngeal SpCCs. The authors examined the patho...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90175-1
更新日期:1997-06-01 00:00:00
abstract::Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.01.013
更新日期:2006-05-01 00:00:00
abstract::Three ovarian thecomas were studied by ultrastructural and immunohistochemical techniques. In each tumor, a small number of tumor cells stained for estradiol. Vacuolated as well as plump non-vacuolated tumor cells were positive, but spindle-shaped cells were negative. Ultrastructural examination showed two principle c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80056-8
更新日期:1984-02-01 00:00:00
abstract::Among 448 malignant epithelial tumors of the gallbladder, 19 were classified as oat cell carcinomas. Seventeen cases occurred in elderly women. Eighteen of the patients had cholelithiasis. The neoplasms were highly lethal, metastasizing early and causing death shortly after diagnosis. All 19 patients died as a direct ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80288-9
更新日期:1984-07-01 00:00:00
abstract::The aim of the current study was to test whether the grade group assessed in the index tumor nodule predicts biochemical recurrence after surgery. The study cohort series included 144 consecutive patients treated by laparoscopic radical prostatectomy. The following parameters were evaluated in each case: type of radic...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.08.012
更新日期:2019-11-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is typically characterized by t(11;14), which places the IGH@ enhancer elements upstream of CCND1. This fusion results in up-regulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untransl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.01.001
更新日期:2017-06-01 00:00:00
abstract::Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.08.017
更新日期:2015-01-01 00:00:00
abstract::One hundred six liver biopsy specimens from 34 orthotopic liver transplant (OLT) patients were examined and the histologic findings correlated with the clinical course of the patients to determine if specific morphologic patterns were associated with specific causes of acute allograft dysfunction. The principle causes...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80268-5
更新日期:1988-07-01 00:00:00
abstract::Breast cancer is one of the common malignant diseases among women in Japan as well as in western countries, and its incidence continues to increase. Normal mammary duct epithelial cells exhibit a well-organized apicobasal polarity, which forms the basis for their specific structure and function. Although the loss of e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.11.001
更新日期:2008-06-01 00:00:00
abstract::The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when em...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.07.011
更新日期:2020-09-01 00:00:00
abstract::The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90005-5
更新日期:1995-08-01 00:00:00
abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90232-4
更新日期:1996-09-01 00:00:00
abstract::Lymphocytic colitis (LC) and LC incomplete (LCi) are common causes of chronic watery diarrhea. The diagnosis relies on clinical findings and histopathologic evaluation. The diagnostic criteria of LC are based on hematoxylin and eosin (HE) staining. However, supplementary immunohistochemical staining for highlighting t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.031
更新日期:2019-02-01 00:00:00
abstract::The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80052-7
更新日期:1987-08-01 00:00:00
abstract::Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified cl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.23523
更新日期:2001-04-01 00:00:00
abstract::The drs gene was originally isolated from a rat primary embryo fibroblast cDNA library as a suppressor gene against v-src transformation. We have previously shown that expression of drs mRNA was markedly reduced in a variety of human cancer cell lines, including those of the colon, bladder, and ovary. Furthermore, int...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.125373
更新日期:2002-06-01 00:00:00
abstract::A 51-year-old man presented with a paratracheal tumor. He had undergone resection of a thyroid tumor 15 years previously; at that time, the histologic diagnosis had been anaplastic carcinoma. When the tumor recurred, the presumptive clinical diagnosis was medullary thyroid carcinoma. Histologic examination revealed a ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80242-9
更新日期:1988-12-01 00:00:00
abstract::Loss of the NF1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene RET (RETp) are purportedly common in desmoplastic melanoma (DM). DM is categorized into pure (PDM) and mixed (MDM) subtypes, which differ in prognosis. Most NF1 mutations result in a truncated/absent protein, making im...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.02.012
更新日期:2016-07-01 00:00:00