The evolving landscape of HPV-related neoplasia in the head and neck.

Abstract:

:Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now includes a newly described entity in the sinonasal tract. A recent study has also suggested a role of HPV in some ocular adnexal sebaceous carcinomas. Herein, we review and concisely summarize the spectrum of HPV-driven neoplasia in the head and neck, with a focus on variant morphologies and newly-described entities including key differential diagnoses and clinical implications.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Devins KM,Tetzlaff MT,Baloch Z,LiVolsi VA

doi

10.1016/j.humpath.2019.09.001

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

29-39

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(19)30166-2

journal_volume

94

pub_type

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