Abstract:
:Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now includes a newly described entity in the sinonasal tract. A recent study has also suggested a role of HPV in some ocular adnexal sebaceous carcinomas. Herein, we review and concisely summarize the spectrum of HPV-driven neoplasia in the head and neck, with a focus on variant morphologies and newly-described entities including key differential diagnoses and clinical implications.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Devins KM,Tetzlaff MT,Baloch Z,LiVolsi VAdoi
10.1016/j.humpath.2019.09.001subject
Has Abstractpub_date
2019-12-01 00:00:00pages
29-39eissn
0046-8177issn
1532-8392pii
S0046-8177(19)30166-2journal_volume
94pub_type
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