Abstract：
:Three cases of primary thymic neuroendocrine tumors characterized by prominent angiomatoid features that resembled a vascular neoplasm are presented. The patients were all men between 52 and 59 years of age who presented with chest pain and shortness of breath attributable to a large anterior mediastinal mass. The lesions ranged in size from 6 cm to 15 cm in greatest diameter, and were grossly soft and well circumscribed, but not encapsulated. The cut surface was remarkable for multiple blood-filled cyst-like spaces admixed with focal solid, hemorrhagic areas. Histologically, the tumors contained multiple cystically dilated spaces filled with blood which imparted the lesion with a striking angiomatoid appearance. The walls of the cysts were lined by a monotonous proliferation of round to oval cells with distinct cell borders, round central nuclei, and abundant eosinophilic cytoplasm. Mitotic activity was present in all cases and varied from 3 to 8 mitoses per 10 high-power fields. Immunohistochemical studies performed in two cases showed positivity of the tumor cells for keratin, Leu 7, and synaptophysin, and focal chromogranin positivity in one. Follow-up information obtained in two patients showed that both had died of tumor 4 and 8 years after initial diagnosis. The present cases show an unusual morphological appearance of thymic neuroendocrine tumors that may be mistaken for a vascular neoplasm. Immunohistochemical stains may be of importance in such instances in arriving at the correct diagnosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Moran CA,Suster Sdoi
10.1016/s0046-8177(99)90087-4subject
Has Abstractpub_date
1999-06-01 00:00:00pages
635-9issue
6eissn
0046-8177issn
1532-8392pii
S0046-8177(99)90087-4journal_volume
30pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Patients undergoing treatment of acute lymphoblastic leukemia are at risk for fungal infections including disseminated candidiasis. We describe a case of systemic Candida albicans infection associated with life-threatening gastrointestinal hemorrhage due to unusual necrotizing vasculitis involving the gastrointestinal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.09.015
更新日期：2010-04-01 00:00:00
abstract：:The immunohistochemical expression of cell adhesion molecules in colorectal serrated adenocarcinoma is still unknown. The immunostaining patterns of β-catenin, E-cadherin, P-cadherin, laminin 5γ2, and SMAD4 and their relationship to survival were studied in different tumor areas, namely, tumor center and invasive fron...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.08.020
更新日期：2012-07-01 00:00:00
abstract：:No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.03.013
更新日期：2017-06-01 00:00:00
abstract：:Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.12.008
更新日期：2014-05-01 00:00:00
abstract：:The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80170-0
更新日期：1981-08-01 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.07.018
更新日期：2018-12-01 00:00:00
abstract：:Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：:A carcinoma of the urinary bladder with a distinct choriocarcinomatous component that developed in a postmenopausal woman was associated with high titers of circulating chorionic gonadotropin. The diagnosis was supported by histochemical demonstration of human chorionic gonadotropin in syncytial tumor giant cells and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80173-2
更新日期：1984-08-01 00:00:00
abstract：:The case of a patient in whom idiopathic thrombocytopenic purpura (ITP) was associated with diffuse splenic histiocytosis is described; the patient's subsequent sphingomyelinase level was at the lower limits of the normal range. The patient's splenic lecithin:sphingomyelin ratio was not significantly different from th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80192-1
更新日期：1985-11-01 00:00:00
abstract：:Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90161-h
更新日期：1991-03-01 00:00:00
abstract：:Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90056-m
更新日期：1993-01-01 00:00:00
abstract：:Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.08.017
更新日期：2015-01-01 00:00:00
abstract：:Recent polymerase chain reaction (PCR)-based studies focused on the detection of immunoglobulin heavy chain gene (IgH) rearrangements have suggested that clonal populations may be amplified more easily from certain categories of B-cell neoplasia than others and that primer makeup can be a critical factor in successful...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90084-1
更新日期：1994-12-01 00:00:00
abstract：:Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90201-5
更新日期：1995-11-01 00:00:00
abstract：:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.027
更新日期：2016-02-01 00:00:00
abstract：:It has been suggested that atypical adenomatous hyperplasia (AAH) may be a precursor of peripheral adenocarcinoma of the lung. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA onto chromosomal ends. Its activity is believed to be crucial for cellular immortality, and it is thought to participate...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125775
更新日期：2002-07-01 00:00:00
abstract：:IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.005
更新日期：2009-11-01 00:00:00
abstract：:The absence of keratin staining in tumor cells from localized fibrous mesotheliomas in both paraffin-embedded and frozen sections with sensitive peroxidase-antiperoxidase and avidin-biotin techniques is described. In addition ot the absence of staining for whole-stratum corneum keratin proteins, sections were negative...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80077-5
更新日期：1984-05-01 00:00:00
abstract：:We describe a case of simultaneous nodular sclerosing Hodgkin's disease and a granulocytic sarcoma in a cervical lymph node without any previous therapy. The condition evolved into acute myelogenous leukemia approximately 8 months after the initial diagnosis of the granulocytic sarcoma. The unexpected presence of a gr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90293-2
更新日期：1996-10-01 00:00:00
abstract：:The objective of this cohort study was to evaluate whether the immunohistochemical expression of tissue inhibitor of metalloprotease 2, matrix metalloproteinase (MMP) 2, and MMP-9 could predict the occurrence of death and progression in women with ovarian high-grade serous carcinoma (HGSC). A total of 100 women with p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.01.014
更新日期：2015-05-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.08.004
更新日期：2008-03-01 00:00:00
abstract：:Primary small bowel adenocarcinoma is rare. Although generally similar to colonic adenocarcinoma, some small bowel adenocarcinomas exhibit unique morphologic features, particularly those arising in association with Crohn disease. In this study, 15 sporadic small bowel adenocarcinomas and 11 Crohn enteritis-associated ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.09.014
更新日期：2014-02-01 00:00:00
abstract：:The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90352-4
更新日期：1992-07-01 00:00:00
abstract：:Because infants rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourag...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80194-6
更新日期：1987-01-01 00:00:00
abstract：:In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.11.012
更新日期：2016-04-01 00:00:00
abstract：:Clear cell sarcoma is a rare and malignant soft tissue tumor that shows phenotypic and immunohistochemical overlap with cutaneous malignant melanoma; identification of biomarkers that differentiate clear cell sarcoma from malignant melanoma is therefore needed. In this study, we performed mutation analysis of BRAF and...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.022
更新日期：2012-09-01 00:00:00
abstract：:The diagnosis of metastatic adenocarcinoma to the brain of unknown primary is problematic, and the role of immunohistochemistry in identifying a source has not been fully characterized. Sixty-eight metastatic adenocarcinomas of the brain with known primaries were immunostained with antibodies to cytokeratin 7 (CK7), c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90009-5
更新日期：1997-08-01 00:00:00
abstract：:Bone Marrow Transplant (BMT) is a critical therapeutic intervention for a variety of diseases occurring in the pediatric patient. Complications of allogeneic BMT include graft-versus-host disease (GVHD), infection, drug toxicity, thrombotic microangiopathy, and veno-occlusive disease. With solid organ transplantation,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90132-6
更新日期：1999-07-01 00:00:00
abstract：:A 57 year old man presented with a two week history of right sided chest pain. An admission chest x-ray examination revealed a 2 by 1 cm. lytic lesion of the ninth right rib and right sided pleural effusion. The patient underwent a right thoracotomy during which 700 cc. of blood tinged pleural fluid was drained and a ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80080-3
更新日期：1980-11-01 00:00:00
abstract：:Lymphoepithelial cysts with histological features characteristic of branchial cleft cysts have been reported to occur rarely in the thyroid gland. To our knowledge only six cases of this lesion have been reported. Since these reports brought this entity to our attention, we have noted that intrathyroidal lymphoepithel...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90042-6
更新日期：1994-11-01 00:00:00
