Testicular atrophy in AIDS: a study of 57 autopsy cases.

abstract：:Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic, and in some cases, neoplastic lesions in human colons. These microscopic lesions, identified on methylene blue-stained mucosa with a low-power-magnification microscope, are thought to be closely related to the earliest steps in multistage coloni...

journal_title：Human pathology

authors： Shpitz B,Bomstein Y,Mekori Y,Cohen R,Kaufman Z,Neufeld D,Galkin M,Bernheim J

更新日期：1998-05-01 00:00:00

abstract：:To better represent the Gleason score of radical prostatectomy, the International Society of Urologic Pathologists Consensus Committee recommends assigning individual Gleason scores to prostate cancer cores submitted in separate containers and/or multiple cores in the same container with site identifiers. However, sce...

journal_title：Human pathology

authors： Kunju LP,Daignault S,Wei JT,Shah RB

更新日期：2009-04-01 00:00:00

abstract：:A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...

journal_title：Human pathology

authors： Dao AH,Netsky MG

更新日期：1984-05-01 00:00:00

abstract：:Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...

journal_title：Human pathology

authors： Furuhata S,Kameya T,Otani M,Toya S

更新日期：1993-01-01 00:00:00

abstract：:Congenital syphilis is often a presumptive diagnosis (based on serologies), because confirmation requires identification of Treponema pallidum in fetal/neonatal tissues or in the placenta. Placental histological features associated with congenital syphilis include the triad of enlarged hypercellular villi, proliferati...

journal_title：Human pathology

authors： Genest DR,Choi-Hong SR,Tate JE,Qureshi F,Jacques SM,Crum C

更新日期：1996-04-01 00:00:00

abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...

journal_title：Human pathology

authors： Karpowicz MK,Shalmon B,Molberg KH,El-Naggar AK

更新日期：2011-09-01 00:00:00

abstract：:Five hundred consecutive breast carcinomas from the first screening round of the Breast Cancer Detection Demonstration Project were studied quantitatively and semiquantitatively for features relevant to the diagnosis of tubular carcinoma. Tubularity was defined as the proportion of tumor cells that were adjacent to an...

journal_title：Human pathology

authors： Stalsberg H,Hartmann WH

更新日期：2000-05-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....

journal_title：Human pathology

authors： Pierson CR,Schober MS,Wallis T,Sarkar FH,Sorensen PH,Eble JN,Srigley JR,Jones EC,Grignon DJ,Adsay V

更新日期：2001-05-01 00:00:00

abstract：:Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...

journal_title：Human pathology

authors： Tsang JY,Mendoza P,Putti TC,Karim RZ,Scolyer RA,Lee CS,Pang AL,Tse GM

更新日期：2012-12-01 00:00:00

abstract：:A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...

journal_title：Human pathology

authors： Abdul-Karim FW,Lederman MM,Carter JR,Hewlett EL,Newman AJ,Greene BM

更新日期：1981-01-01 00:00:00

abstract：:Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...

journal_title：Human pathology

authors： Velez N,Jukic D,Ho J

更新日期：2008-09-01 00:00:00

abstract：:In a prior study we reported that monotypic immunoglobulin expression significantly correlated with an increased risk of dissemination by small lymphocytic infiltrates (SLIs) of the orbit and conjunctiva. However, less than half of all monotypic SLIs disseminated. In this study, we applied a large panel of monoclonal ...

journal_title：Human pathology

authors： Medeiros LJ,Harris NL

更新日期：1990-11-01 00:00:00

abstract：:The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...

journal_title：Human pathology

authors： Vance RP,Prichard RW,Smith RD

更新日期：1991-11-01 00:00:00

abstract：:Proliferative lesions of breast duct epithelium are associated with an increased risk of subsequent carcinoma. Fine-needle aspiration criteria for these lesions are poorly defined; most studies are retrospective and do not clearly use the classification of Page and Rogers. Suggested criteria for "atypia" include crowd...

journal_title：Human pathology

authors： Stanley MW,Henry-Stanley MJ,Zera R

更新日期：1993-06-01 00:00:00

abstract：:The natural history of pediatric nonalcoholic steatohepatitis is still unknown; however, there are differences between adult and pediatric presentation. Apoptosis may play an important role in pathophysiologic pathways involved in liver damage and progression. Our aim was to detect early apoptosis markers, activated c...

journal_title：Human pathology

authors： Valva P,De Matteo E,Galoppo M,Pedreira A,Giacove G,Lezama C,Marco I,Galoppo MC,Preciado MV

更新日期：2008-12-01 00:00:00

abstract：:SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was established using limited samples and resources. A woman in her early 30s developed...

journal_title：Human pathology

authors： Kuwamoto S,Matsushita M,Takeda K,Tanaka N,Endo Y,Yamasaki A,Kohashi K,Oda Y,Horie Y

更新日期：2017-12-01 00:00:00

abstract：:The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...

journal_title：Human pathology

authors： Conley FK,Jenkins KA,Remington JS

更新日期：1981-08-01 00:00:00

abstract：:Neutrophilic dermatoses are an uncommon manifestation of lupus. We describe the clinical and histopathologic features of 14 patients with systemic lupus erythematosus (SLE) and neutrophilic dermatoses, 2 of whom had no prior history of SLE. Thirteen patients were female, ranging in age from 27 to 62 years (mean age, 4...

journal_title：Human pathology

authors： Larson AR,Granter SR

更新日期：2014-03-01 00:00:00

abstract：:This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological e...

journal_title：Human pathology

authors： Kanno H,Onodera H,Endo M,Maeda F,Chida S,Akasaka T,Sawai T

更新日期：2005-02-01 00:00:00

abstract：:NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...

journal_title：Human pathology

authors： Ma YY,Zhang GH,Li J,Wang SB,Hu ZM,Zhang CW,Li E

更新日期：2018-12-01 00:00:00

abstract：:The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...

journal_title：Human pathology

authors： Boiocchi L,Hasserjian RP,Pozdnyakova O,Wong WJ,Lennerz JK,Le LP,Dias-Santagata D,Iafrate AJ,Hobbs GS,Nardi V

更新日期：2019-04-01 00:00:00

abstract：:Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...

journal_title：Human pathology

authors： Doss BJ,Jacques SM,Qureshi F,Ramirez NC,Lawrence WD

更新日期：1998-02-01 00:00:00

abstract：:Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase (IDH) genes represent a novel class of point mutations in acute myeloid leukemia. These mutations prevent oxidative decarboxylation of isocitrate to α-ketoglutarate and confer novel enzymatic activity, facilitating t...

journal_title：Human pathology

authors： Rakheja D,Konoplev S,Medeiros LJ,Chen W

更新日期：2012-10-01 00:00:00

abstract：:Mucoepidermoid carcinoma of the breast is a rare entity with specific morphologic and immunohistochemical features similar to its salivary gland counterpart. In the 28 reported cases to date, there has not been a comparison of the molecular characteristics of this tumor with salivary gland mucoepidermoid carcinomas. H...

journal_title：Human pathology

authors： Camelo-Piragua SI,Habib C,Kanumuri P,Lago CE,Mason HS,Otis CN

更新日期：2009-06-01 00:00:00

abstract：:The case of a 65-year-old female patient with a pedunculated left atrial angiosarcoma is presented. Histologically, the tumor was composed of vascular spaces lined by atypical cells with similar cells in the solid portion of the tumor. Immunohistochemical stain for factor VIII-related antigen was positive in the cells...

journal_title：Human pathology

authors： Keohane ME,Lazzam C,Halperin JL,Strauchen JA,Ergin MA

更新日期：1989-06-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal adhesion sites, which are specific areas on the cell membrane where cells attach to extracellular matrix proteins. Focal adhesion kinase interacts with multiple signaling and adaptor molecules and effects several signaling pathways. O...

journal_title：Human pathology

authors： Madan R,Smolkin MB,Cocker R,Fayyad R,Oktay MH

更新日期：2006-01-01 00:00:00

abstract：:IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...

journal_title：Human pathology

authors： Walter O,Prasad M,Lu S,Quinlan RM,Edmiston KL,Khan A

更新日期：2009-11-01 00:00:00

abstract：:Disruptions of the p16-CDK4/cyclin D1-pRb pathway (RB pathway) and the p14ARF-MDM2-p53 pathway (p53 pathway) are important mechanisms in the development of human malignancies. In this study, we investigated RB and p53 pathways in 46 epithelial ovarian cancers (EOCs). In the RB pathway, 16 (34.8%) of 46 cases had p16 g...

journal_title：Human pathology

authors： Hashiguchi Y,Tsuda H,Yamamoto K,Inoue T,Ishiko O,Ogita S

更新日期：2001-09-01 00:00:00

abstract：:Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic ca...

journal_title：Human pathology

authors： Chen X,Zhao J,Salim S,Garcia FU

更新日期：2006-03-01 00:00:00

abstract：:The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy wh...

journal_title：Human pathology

authors： Yuen AR,Higgins JP,Baker R,Kamel OW,Warnke RA,Knox SJ

更新日期：2003-04-01 00:00:00