Abstract:
:Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic, and in some cases, neoplastic lesions in human colons. These microscopic lesions, identified on methylene blue-stained mucosa with a low-power-magnification microscope, are thought to be closely related to the earliest steps in multistage colonic tumorigenesis. We investigated the distribution pattern and histomorphological features of ACF in 74 patients with sporadic colorectal cancer. The distribution pattern shows a slightly higher prevalence with older age. The prevalence of the ACF in sigmoid colon was significantly higher in patients with colorectal cancer as compared with patients with benign colonic diseases. Also, significantly more ACF were detected in distal parts of the large bowel (descending, sigmoid colon, and rectum) than in proximal parts. Of 42 microdissected lesions, 12 were dysplastic and 30 were hyperplastic foci. The average size of dysplastic lesions was significantly larger than hyperplastic foci. More apoptotic bodies were found in dysplastic lesions. These lesions also showed an upward expansion of proliferative compartment and higher proliferation indices expressed as proliferating cell nuclear antigen-labeling index. Lymphoid follicles were frequently observed in the base of both hyperplastic and dysplastic foci (40% and 66.6%, respectively). The coincidence of lymphoid follicles was 2.5 to 8 times higher than expected. These features may be related to further progression of selected ACF during colorectal tumorigenesis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Shpitz B,Bomstein Y,Mekori Y,Cohen R,Kaufman Z,Neufeld D,Galkin M,Bernheim Jdoi
10.1016/s0046-8177(98)90062-4subject
Has Abstractpub_date
1998-05-01 00:00:00pages
469-75issue
5eissn
0046-8177issn
1532-8392pii
S0046-8177(98)90062-4journal_volume
29pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Liver involvement in amyloidosis is rarely associated with intrahepatic cholestasis. The cases recorded in the literature indicate that there is a tendency toward periportal deposition, leading to centrilobular cholestasis. Our case was most interesting in that the amyloid deposition was most severe in the centrilobul...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80029-9
更新日期:1981-05-01 00:00:00
abstract::T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.030
更新日期:2017-07-01 00:00:00
abstract::The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.11.022
更新日期:2019-04-01 00:00:00
abstract::The immunohistochemical expression of cell adhesion molecules in colorectal serrated adenocarcinoma is still unknown. The immunostaining patterns of β-catenin, E-cadherin, P-cadherin, laminin 5γ2, and SMAD4 and their relationship to survival were studied in different tumor areas, namely, tumor center and invasive fron...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.08.020
更新日期:2012-07-01 00:00:00
abstract::Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90121-6
更新日期:1998-04-01 00:00:00
abstract::A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90094-5
更新日期:1996-05-01 00:00:00
abstract::Of the approximately 635 residents in each year of pathology training, about 165 are already meeting the Pathology Board's proposed requirement for a fifth year of resident training. The cost of a fifth year of training for the other 470 residents is estimated to be approximately $20 million. Options for avoiding this...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80159-8
更新日期:1984-08-01 00:00:00
abstract::Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(98)90003-x
更新日期:1998-12-01 00:00:00
abstract::Invasive mammary carcinoma with neuroendocrine differentiation has been controversial in terms of its definition and clinical outcome. In 2003, the World Health Organization histologic classification of tumors designated this entity as neuroendocrine carcinoma of the breast and defined mammary neuroendocrine carcinoma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.11.014
更新日期:2011-08-01 00:00:00
abstract::We examined the effect of lateral spatial resolution and reader specialty on the accuracy of detection of breast cancer. The motivation for this pilot study was the need to acquire and display very large data sets in whole-specimen 3D digital breast histopathology imaging. The ultimate goal is to determine the minimum...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.04.006
更新日期:2007-12-01 00:00:00
abstract::Sections of synovium from 393 operations on diseased joints were re-examined without knowledge of the clinical findings. Specimens were scored for each of 37 histopathologic features. Independently, patients were assigned to one of 10 diagnostic groups after review of all available clinical data. Computer analysis rev...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80141-4
更新日期:1981-04-01 00:00:00
abstract::The relationship between nuclear diameter and biologic behavior was studied in 127 cases of thyroid carcinoma. Using a sonic digitizer coupled to a minicomputer, nuclear diameters of 200 randomly selected cancer cells from each case (hematoxylineosin-stained paraffin sections) projected at X 400 magnification were tra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80409-4
更新日期:1987-12-01 00:00:00
abstract::The Ewing family of tumors (EFT) is characterized by high MIC2/CD99 expression and specific EWS/ETS gene rearrangements, resulting in different chimeric transcripts. Further division into peripheral primitive neuroectodermal tumors and Ewing's sarcoma is still debated and, in the absence of distinct morphological para...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90223-x
更新日期:1999-09-01 00:00:00
abstract::To achieve real-time connectivity between its 8 hopital-based laboratories, Veterans Integrated Service Network (VISN) 12, headquartered in Chicago, IL, has implemented a hybrid dynamic store-and-forward (HDSF) telepathology network that extends across portions of 3 states. The majority of diagnostic telepathology fun...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.29644
更新日期:2001-12-01 00:00:00
abstract::Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.010
更新日期:2004-10-01 00:00:00
abstract::T3 renal cell carcinoma (RCC) is a heterogeneous group of tumors that are substaged based on perirenal or sinus fat invasion, adrenal invasion, and renal vein invasion. To evaluate whether the extent of fat invasion (minimal versus extensive) and direct adrenal gland invasion, renal vein invasion with or without concu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.04.011
更新日期:2008-11-01 00:00:00
abstract::CD44 is an integral membrane glycoprotein that is a principal receptor for hyaluronan and plays a role in cell-extracellular matrix interactions. Recent studies of melanomas in mouse models have suggested that increased CD44 expression by these tumors may relate to metastatic potential. Immunohistochemical expression ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90339-1
更新日期:1996-12-01 00:00:00
abstract::A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80247-2
更新日期:1987-07-01 00:00:00
abstract::Glomerulonephritis (GN) characterized by immune complex deposits typical of postinfectious GN but with a paucity or absence of overt clinical symptoms and/or urinary abnormalities may occur after a group A streptococcus infection. The overall incidence of this type of subclinical GN is not known. To address this quest...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.53
更新日期:2003-01-01 00:00:00
abstract::Two cases of lymphadenopathy resulting from a lymph node foreign body reaction to silicone are presented. In each case lymph node biopsy was performed because of the clinical suspicion of neoplastic disease. Histologic study in both cases revealed no evidence of malignant disease, but rather demonstrated multinucleate...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(80)80005-0
更新日期:1980-05-01 00:00:00
abstract::Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.006
更新日期:2018-02-01 00:00:00
abstract::Fatty acids are implicated in tumorigenesis, but data are limited concerning endogenous fatty acid metabolism of tumor cells in adenomas and adenocarcinomas of the small intestine. The recently cloned human acyl-CoA-synthetase 5 (ACS5) is predominantly found in the small intestine and represents a key enzyme in provid...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/s0046-8177(03)00431-3
更新日期:2003-10-01 00:00:00
abstract::To investigate the possibility of human immunodeficiency virus-(HIV) 1 infection of liver cells, liver samples from 17 patients with either acquired immunodeficiency syndrome (AIDS, 13), AIDS-related complex (ARC, 3), or lymphadenopathy syndrome (LAS, 1) were studied. A monoclonal antibody directed against the p24 gag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90202-g
更新日期:1990-04-01 00:00:00
abstract::An immunohistochemical survey of X-linked inhibitor of apoptosis (XIAP) expression in mammary carcinoma was performed. XIAP, the most potent of the inhibitor of apoptosis family of caspase inhibitors, has been linked to tumor aggressiveness and therapeutic resistance in several malignancies and is considered an attrac...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.016
更新日期:2007-06-01 00:00:00
abstract::Four surgically resected cardiac valves received from three female patients showed the presence of acute and chronic rheumatic valvulitis. The material was studied by means of transmission and scanning electron microscopy. This is the first time that there has been an investigation of the ultrastructure in acute rheum...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(80)80109-2
更新日期:1980-01-01 00:00:00
abstract::Germline BRCA mutations account for a significant proportion of genetic/familial risk of breast and ovarian cancer (GBOC) susceptibility, but a broader spectrum of GBOC susceptibility genes has emerged in recent years. Genotype-to-phenotype correlations are known for some established forms of GBOC; however, whether su...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.06.018
更新日期:2017-12-01 00:00:00
abstract::Analogous to mixed tumors of salivary glands (" pleomorphic adenomas" ), cutaneous mixed tumors (" chondroid syringomas" ) contain a ductal (epithelial) component and a variably prominent myoepithelial component. Tumors showing purely myoepithelial differentiation (myoepitheliomas) have only recently been recognized t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.08.016
更新日期:2004-01-01 00:00:00
abstract::Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90220-8
更新日期:1994-06-01 00:00:00
abstract::The precise regulation and maintenance of balance between cell proliferation and cell death in multicellular organisms is critical for tissue homeostasis. bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Expression of Bcl-2 has been reported ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(96)90362-7
更新日期:1996-02-01 00:00:00
abstract::Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.03.011
更新日期:2004-08-01 00:00:00