The histone methyltransferase G9a: a new therapeutic target in biliary tract cancer.

abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...

journal_title：Human pathology

authors： Kataoka Y,Shimada H,Sugimoto T,Mine H,Hachitanda Y,Doi Y,Sawada T,Weeks DA

更新日期：1993-09-01 00:00:00

abstract：:Fatty acids are implicated in tumorigenesis, but data are limited concerning endogenous fatty acid metabolism of tumor cells in adenomas and adenocarcinomas of the small intestine. The recently cloned human acyl-CoA-synthetase 5 (ACS5) is predominantly found in the small intestine and represents a key enzyme in provid...

journal_title：Human pathology

authors： Gassler N,Schneider A,Kopitz J,Schnölzer M,Obermüller N,Kartenbeck J,Otto HF,Autschbach F

更新日期：2003-10-01 00:00:00

abstract：:Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are di...

journal_title：Human pathology

authors： Subietas A,Deppisch LM,Astarloa J

更新日期：1977-05-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lym...

journal_title：Human pathology

authors： Engels EA,Mbulaiteye SM,Othieno E,Gomez M,Mathew S,Cesarman E,Knowles DM,Chadburn A

更新日期：2007-02-01 00:00:00

abstract：:Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal ...

journal_title：Human pathology

authors： Vanderbeck S,Bockhorst J,Kleiner D,Komorowski R,Chalasani N,Gawrieh S

更新日期：2015-05-01 00:00:00

abstract：:Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and β-catenin expression measured by immunohi...

journal_title：Human pathology

authors： Cheng Y,Zhou Y,Jiang W,Yang X,Zhu J,Feng D,Wei Y,Li M,Yao F,Hu W,Xiao W,Ling B

更新日期：2012-08-01 00:00:00

abstract：:Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...

journal_title：Human pathology

authors： Häusler M,Schaade L,Ramaekers VT,Doenges M,Heimann G,Sellhaus B

更新日期：2003-03-01 00:00:00

abstract：:We describe a patient with adenosquamous carcinoma of the prostate. His history suggests a common histogenesis of the glandular and squamous elements of the tumor. A 60-year-old white man had adenocarcinoma of the prostate diagnosed by biopsy and then underwent radical prostatectomy, which showed adenosquamous carcino...

journal_title：Human pathology

authors： Gattuso P,Carson HJ,Candel A,Castelli MJ

更新日期：1995-01-01 00:00:00

abstract：:We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...

journal_title：Human pathology

authors： Deligdisch L,Kerner H,Cohen CJ,Dargent D,Gil J

更新日期：1993-02-01 00:00:00

abstract：:The concept of minimal deviation melanoma is presented in diagrammatic form. In this approach, the precursors of melanoma are presented as having two dimensions and melanomas as having three dimensions. In turn, the relativity between dimensionalities and recommendations for treatment (as indirect correlates of progno...

journal_title：Human pathology

authors： Reed RJ

更新日期：1999-05-01 00:00:00

abstract：:Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...

journal_title：Human pathology

authors： Hu M,Li K,Maskey N,Xu Z,Yu F,Peng C,Li Y,Yang G

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...

journal_title：Human pathology

authors： Mangia A,Malfettone A,Saponaro C,Tommasi S,Simone G,Paradiso A

更新日期：2011-11-01 00:00:00

abstract：:Pulmonary nodular lymphoid hyperplasia (PNLH) may show heavy lymphoplasmacytic infiltrates with increased immunoglobulin G4 (IgG4)-positive plasma cells as in IgG4-related disease (IgG4-RD). However, it is unclear whether PNLH could be a manifestation of IgG4-RD. A recent study reported the presence of Epstein-Barr vi...

journal_title：Human pathology

authors： Bois MC,Sekiguchi H,Ryu JH,Yi ES

更新日期：2017-01-01 00:00:00

abstract：:Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed H...

journal_title：Human pathology

authors： Stoler MH,Rhodes CR,Whitbeck A,Wolinsky SM,Chow LT,Broker TR

更新日期：1992-02-01 00:00:00

abstract：:An unusual case of multiple myeloma in an 88-year-old patient is described. Besides skeletal involvement, there was myeloma of the thoracic and abdominal lymph nodes and of the liver and pancreas. In the pancreas, the myeloma extensively involved the head and body, and on computerized tomography scan was suggestive of...

journal_title：Human pathology

authors： Bell HG,David R,Shamsuddin AM

更新日期：1982-10-01 00:00:00

abstract：:Yes-associated protein, a downstream effector of the Hippo signaling pathway, has been linked to progression of non-small-cell lung carcinoma. The aim of this study was to investigate expression of Yes-associated protein in lung adenocarcinoma and squamous cell carcinoma. Associations of Yes-associated protein express...

journal_title：Human pathology

authors： Kim JM,Kang DW,Long LZ,Huang SM,Yeo MK,Yi ES,Kim KH

更新日期：2011-03-01 00:00:00

abstract：:We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces wer...

journal_title：Human pathology

authors： Michal M,Skálová A,Kazakov DV,Pecková K,Heidenreich F,Grossmann P,Michal M

更新日期：2017-03-01 00:00:00

abstract：:No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...

journal_title：Human pathology

authors： Wei Q,Zhou H,Zhong L,Shi L,Liu J,Yang Q,Zhao T

更新日期：2017-06-01 00:00:00

abstract：:Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue...

journal_title：Human pathology

authors： Flucke U,Mentzel T,Verdijk MA,Slootweg PJ,Creytens DH,Suurmeijer AJ,Tops BB

更新日期：2012-05-01 00:00:00

abstract：:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...

journal_title：Human pathology

authors： Silver MM,Vilos GA,Silver MD,Shaheed WS,Turner KL

更新日期：1984-12-01 00:00:00

abstract：:Two episodes of severe, relapsing sensorimotor polyneuropathy closely paralleled the course of systemic illness in a patient with immunoblastic lymphadenopathy. A review of the literature shows three other cases, although none with documented pathologic changes in muscles and nerves. Based on the pathologic findings i...

journal_title：Human pathology

authors： Cytowic RE,Challa VR,Buss DH,Angelo JN

更新日期：1982-02-01 00:00:00

abstract：:CD10 is common in B-precursor acute lymphoblastic leukemia (ALL) but is rare in acute myeloid leukemia (AML). However, until recently, analysis for CD10 has generally required fresh or frozen tissue. 56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraf...

journal_title：Human pathology

authors： Bavikatty NR,Ross CW,Finn WG,Schnitzer B,Singleton TP

更新日期：2000-09-01 00:00:00

abstract：:Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...

journal_title：Human pathology

authors： Baker PM,Young RH

更新日期：2000-06-01 00:00:00

abstract：:Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...

journal_title：Human pathology

authors： Hazelbag HM,Van den Broek LJ,Fleuren GJ,Taminiau AH,Hogendoorn PC

更新日期：1997-02-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumor is a malignant tumor showing nerve sheath differentiation. Approximately one-half of malignant peripheral nerve sheath tumors arise from a benign peripheral nerve sheath tumor, which is commonly a neurofibroma in patients with neurofibromatosis type 1. Malignant peripheral nerve...

journal_title：Human pathology

authors： Endo M,Yamamoto H,Harimaya K,Kohashi K,Ishii T,Setsu N,Iwamoto Y,Oda Y

更新日期：2013-12-01 00:00:00

abstract：:Glypican 3 is a heparin sulfate proteoglycan bound to the cell surface that is theorized to participate in cell signaling, resulting in embryonic cell growth and differentiation. The GPC3 gene is mutated in Simpson-Golabi-Behmel syndrome, whose features include numerous developmental abnormalities, tissue overgrowth, ...

journal_title：Human pathology

authors： Zynger DL,Gupta A,Luan C,Chou PM,Yang GY,Yang XJ

更新日期：2008-02-01 00:00:00

abstract：:A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...

journal_title：Human pathology

authors： Asada Y,Marutsuka K,Mitsukawa T,Kuribayashi T,Taniguchi S,Sumiyoshi A

更新日期：1996-05-01 00:00:00

abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

journal_title：Human pathology

authors： Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

更新日期：1999-04-01 00:00:00

abstract：:It has been suggested that inferences about fetal karyotype can be made from examination of placental and decidual histology in early, spontaneous abortions (SABs). We assessed the reproducibility and predictive value of histologic features in 75 karyotyped, first trimester SABs; 32% (24 of 75) had normal male karyoty...

journal_title：Human pathology

authors： Genest DR,Roberts D,Boyd T,Bieber FR

更新日期：1995-02-01 00:00:00

abstract：:Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and l...

journal_title：Human pathology

authors： Ro JY,Silva EG,Gallager HS

更新日期：1987-12-01 00:00:00