Abstract：
:We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces were lined by flat, cuboidal, or columnar epithelial cells, in most parts showing mucinous differentiation. The epithelial lining of the cysts strongly expressed cytokeratins AE1-3, CK7, CK8, CK18, CK19, EMA, and S100 protein. The stroma expressed CD34 and smooth muscle actin. No cytological atypia or mitoses were present, and the proliferative activity was less than 1% in both components. The clonality analysis proved the clonal nature of the neoplasm. We believe that this tumor is a new member in the family of neoplasms containing the OS, and therefore we propose the term mixed epithelial and stromal tumor of the middle ear.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Michal M,Skálová A,Kazakov DV,Pecková K,Heidenreich F,Grossmann P,Michal Mdoi
10.1016/j.humpath.2016.09.020subject
Has Abstractpub_date
2017-03-01 00:00:00pages
199-204eissn
0046-8177issn
1532-8392pii
S0046-8177(16)30244-1journal_volume
61pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:GATA3 immunostaining is a sensitive marker for mammary and urothelial carcinomas. It is routinely used in surgical pathology during workup of carcinomas of unknown origin. To the best of our knowledge, this is the first focused study of GATA3 expression in gallbladder adenocarcinomas. In this study, we evaluated GATA3...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.012
更新日期：2020-12-01 00:00:00
abstract：:In the present study the clinical and pathological evolution of a reactive-like B-cell lymphoproliferative disorder with an unusually high content of T cells is described. Immunogenotypic analysis showed that the same phenotypically atypical B-cell clone, characterized by the unusual presence of an immunoglobulin (Ig)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90070-5
更新日期：1995-03-01 00:00:00
abstract：:The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80107-4
更新日期：1981-02-01 00:00:00
abstract：:We compared the DNA content (DI) by cell image analysis with the karyotype and morphological phenotype of paraffin-embedded tissues from 51 spontaneous abortions. The study included 21 cases with triploid, 19 cases with diploid, and 11 cases with aneuploid (monosomic, trisomic, or mosaic) karyotype. Measurements were ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90209-x
更新日期：1998-09-01 00:00:00
abstract：:Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome in several cancers. Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 and GLUT-2 expression in 149 intrahepatic cholangiocarc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.03.008
更新日期：2014-08-01 00:00:00
abstract：:Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.05.016
更新日期：2014-09-01 00:00:00
abstract：:A 35-year-old white Jewish homosexual man who had undergone surgery and chemotherapy for an embryonal carcinoma of the testis subsequently developed Kaposi's sarcoma. The neoplasm involved the skin as well as visceral tissues. Tissue derived from a biopsy specimen of one of the skin lesions was used in the in situ hyb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80063-4
更新日期：1982-10-01 00:00:00
abstract：:In this report, we present the clinicopathologic features of 13 cases of the invasive micropapillary variant of urothelial carcinoma. This is a rare and aggressive variant of bladder cancer recognized by the current World Health Organization classification of urologic tumors. The micropapillary component varied from 5...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.11.018
更新日期：2010-08-01 00:00:00
abstract：:We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Gr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.30185
更新日期：2002-01-01 00:00:00
abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.032
更新日期：2006-06-01 00:00:00
abstract：:Microsatellite instability (MSI) defines a specific type of genetic instability. Although consensus diagnostic criteria for MSI definition in colorectal cancer have been established, their utility in other tumor types remain to be proven. Previously we developed a mathematical model for MSI definition in colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.10.021
更新日期：2004-03-01 00:00:00
abstract：:This report describes a 47-year-old man with Erdheim-Chester disease (EC), the second case reported in Japan. The patient complained of knee pain, and the roentgenogram of the bilateral legs revealed symmetric osteolytic lesions with sclerosis of the metaphyseal regions of the long bones. Histological examination of t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90145-8
更新日期：1996-01-01 00:00:00
abstract：:The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2016.01.001
更新日期：2016-06-01 00:00:00
abstract：:The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90125-1
更新日期：1989-03-01 00:00:00
abstract：:We have previously reported that the drs gene has the ability to suppress transformation by v-src and v-K-ras in the rat cell line F2808. We have also shown that the expression of drs mRNA is markedly reduced in a variety of human cancer cell lines, suggesting that down-regulation of drs mRNA is correlated with the de...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00240-5
更新日期：2003-07-01 00:00:00
abstract：:Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conven...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80182-8
更新日期：1983-11-01 00:00:00
abstract：:The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicula...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.01.035
更新日期：2012-01-01 00:00:00
abstract：:Bfl-1, a member of the Bcl-2 gene family, blocks p53-mediated apoptosis and has oncogenic transforming activity. In normal tissues, the transcript of Bfl-1 is expressed abundantly in bone marrow and at a low level in several other tissues. In previous experiments, elevated expression of Bfl-1 was observed by Northern ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90282-9
更新日期：1998-07-01 00:00:00
abstract：:Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:Two extraskeletal myxoid chondrosarcomas were examined by electron microscopy. In addition to the well-described ultrastructural features indicative of chondroblastic origin, both of these chondrosarcomas had unusual parallel microtubules packed within rough endoplasmic reticulum. This paper reviews the differential d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80036-3
更新日期：1986-05-01 00:00:00
abstract：:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90015-9
更新日期：1994-09-01 00:00:00
abstract：:GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.05.022
更新日期：2013-11-01 00:00:00
abstract：:Abnormal nuclear megakaryocytic staining for phospho-STAT5 (pSTAT5) correlates with JAK2 V617F mutational status in non-chronic myelogenous leukemia chronic myeloproliferative disorders. However, a proportion of wild-type JAK2 non-chronic myelogenous leukemia chronic myeloproliferative disorders cases also demonstrate...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.10.034
更新日期：2008-07-01 00:00:00
abstract：:Aberrant expression of the antiapoptotic protein BCL (B-cell lymphoma)-2 in neoplastic germinal centers is one of the diagnostic hallmarks of follicular lymphoma. If BCL-2 cannot be detected by immunohistochemistry, the distinction between florid follicular hyperplasia and follicular lymphoma might become a diagnostic...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2011.05.018
更新日期：2012-03-01 00:00:00
abstract：:We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80101-3
更新日期：1976-09-01 00:00:00
abstract：:Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90448-8
更新日期：1998-08-01 00:00:00
abstract：:Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80467-1
更新日期：1986-04-01 00:00:00
abstract：:The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.129416
更新日期：2002-11-01 00:00:00
abstract：:Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract. Malignant gastrointestinal neuroectodermal tumors typically consist of sheet-like to pseudopapillary proliferation of primitive-appearing epithelioid cell...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.05.026
更新日期：2016-11-01 00:00:00
abstract：:Although the Revised European-American Lymphoma Classification does not utilize the term monocytoid B-cell Lymphoma, there are numerous reasons to support its use in classifying lymphomas of so-called marginal zone B-cell type that contain a distinct population of malignant monocytoid B-cells. In addition, there are o...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(97)90277-x
更新日期：1997-01-01 00:00:00
