Abstract:
:The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated forms of these two tumors. We evaluated a series of 40 PAC cases (Gleason's grade >/= 8) and 45 (G3) UC cases obtained from transurethral endoscopic resection material. Immunohistochemical analysis was performed using the following antibodies: prostate acid phosphatase (PAP), prostate-specific antigen (PSA), uroplakin III (UP), thrombomodulin (TM), cytokeratin (CK) 7, and CK20. PAC expressed PSA and PAP in 34 and 38 cases, respectively. The sensitivity and specificity of expressing at least 1 marker (PSA+ or PAP+) is 95% and 100%, respectively. All UC cases were negative for both markers. UC expressed UP and TM in 27 and 22 cases, respectively. In addition, 36 of 45 cases stained positively for at least 1 marker (UP + or TM +) with specificity and sensitivity of 80% and 100%, respectively. All cases of PAC were negative for both markers. Twenty-eight UC cases were CK7+/CK20 +, and 4 PAC cases stained positively for both markers. On the other hand, 29 PAC cases and 4 UC cases were CK7-/CK20-. We concluded that PSA, PAP, UP, and TM are very useful markers in differentiating poorly differentiated UC from PAC. Finally, when all 4 markers (PAP, PSA, UP, and TM) were negative, CK7 and CK20 appeared of no major use in making the differential diagnosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Mhawech P,Uchida T,Pelte MFdoi
10.1053/hupa.2002.129416subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1136-40issue
11eissn
0046-8177issn
1532-8392pii
S0046817702001685journal_volume
33pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Although mast cell proliferation in the bone marrow frequently occurs in systemic mastocytosis and is often associated with radiographically detectable bone lesions, the pathologic correlates of the skeletal abnormalities are poorly characterized. We therefore examined three nondecalcified transiliac crest biopsy spec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80084-6
更新日期:1981-09-01 00:00:00
abstract::Congenital cystic adenomatoid malformation (CCAM) of the lung is a congenital lesion that is sometimes complicated by bronchioloalveolar adenocarcinoma (BAC). In some cases foci of atypical goblet cell hyperplasia (AGCH) can be found within the cysts. It has been proposed that CCAM and AGCH predispose to the developme...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.01.008
更新日期:2004-05-01 00:00:00
abstract::Infiltrating ductal carcinoma of the breast is histologically heterogeneous and may be subdivided into three main types (A, B, and C) which correlate with the likelihood of long-term survival. Examples of each type were tested against three monoclonal antibodies (H59, H71, and H72) prepared against the breast cancer c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80375-1
更新日期:1987-11-01 00:00:00
abstract::Twenty-five cases of Crohn's disease confined to the appendix were reported in eight hospitals in Israel during a 15-year period. Review of the histologic slides confirmed the diagnosis in 22 cases. Re-evaluation of these 22 patients included physical examination and radiologic studies of the small and large bowel. Re...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80416-6
更新日期:1986-11-01 00:00:00
abstract::Several matrix metalloproteinases (MMPs) are implicated in the degradation of the epithelial basement membrane (BM), invasiveness, and malignancy of endometrial and ovarian carcinomas. We have recently proposed a cooperative role for RUNX1/AML1 and ETV5/ERM in myometrial infiltration during endometrioid endometrial in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.01.025
更新日期:2011-01-01 00:00:00
abstract::The reliability of a diagnostic test depends on the reproducibility of the result. Many clinical diagnostic tests can be quantified with established ranges and standard deviations. Other tests are more subjective, such as those that depend on analysis of a visual image with an increased possibility of variance in the ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(96)90157-4
更新日期:1996-06-01 00:00:00
abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2006.10.006
更新日期:2007-04-01 00:00:00
abstract::Cancer-related axonogenesis and neurogenesis are recently described biologic phenomena. Our previously published data showed that nerve density and the number of neurons in the parasympathetic ganglia are increased in prostate cancer (PCa) and associated with aggressive disease. Tissue microarrays were constructed fro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.02.009
更新日期:2014-07-01 00:00:00
abstract::Total parenteral nutrition (TPN) therapy is a well-recognized cause of liver injury. The histologic changes attributed to TPN in the literature vary widely. In this study, we describe the histopathologic changes associated with TPN therapy and relate these changes to various clinical parameters. We conducted a retrosp...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.07.008
更新日期:2012-06-01 00:00:00
abstract::We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90120-6
更新日期:1993-09-01 00:00:00
abstract::Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.03.012
更新日期:2011-10-01 00:00:00
abstract::The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.01.001
更新日期:2016-06-01 00:00:00
abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.009
更新日期:2008-06-01 00:00:00
abstract::The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.05.025
更新日期:2011-02-01 00:00:00
abstract::Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.009
更新日期:2006-09-01 00:00:00
abstract::Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant pure type being mainly virus positive. Indications that different bi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.008
更新日期:2015-09-01 00:00:00
abstract::The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129420
更新日期:2002-11-01 00:00:00
abstract::Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.10.016
更新日期:2018-01-01 00:00:00
abstract::Sixteen cases of intermediate lymphocytic lymphoma (ILL), including eight cases with mantle zone architecture, were studied using cryostat sections, a biotin-avidin immunoperoxidase technique, and a large panel of monoclonal antibodies. The neoplastic cells invariably expressed IgM, most B lineage antigens (B1, TO15, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80203-x
更新日期:1988-05-01 00:00:00
abstract::No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.03.013
更新日期:2017-06-01 00:00:00
abstract::Lipomatous lesions of the heart involving the atria and interatrial septum are not well known. Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.028
更新日期:2006-10-01 00:00:00
abstract::This study explored the importance of hepatitis B virus infection in cholangiocarcinoma pathogenesis in northern China. The clinical data of 66 patients with cholangiocarcinoma were analyzed. The hepatitis B virus gene was amplified using nested polymerase chain reaction, and the hepatitis B virus-related antigen was ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.04.004
更新日期:2012-01-01 00:00:00
abstract::Four cases of clear cell lymphoma were studied by means of light and electron microscopy, enzyme-histochemistry, and E- and EAC-rosette formation. On light microscopic examination the tumors were seen to be composed mainly of round, oval, or slight irregular cells with water-clear, abundant cytoplasm. The neoplastic c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80258-2
更新日期:1988-07-01 00:00:00
abstract::Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90041-m
更新日期:1991-02-01 00:00:00
abstract::Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.012
更新日期:2004-10-01 00:00:00
abstract::To investigate the possibility of human immunodeficiency virus-(HIV) 1 infection of liver cells, liver samples from 17 patients with either acquired immunodeficiency syndrome (AIDS, 13), AIDS-related complex (ARC, 3), or lymphadenopathy syndrome (LAS, 1) were studied. A monoclonal antibody directed against the p24 gag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90202-g
更新日期:1990-04-01 00:00:00
abstract::To increase awareness of the possible coexistence of an ovarian and breast carcinoma in a BRCA1 mutation carrier, we describe a patient with primary ovarian cancer who developed distant metastases after 3 years and again after 6 years. Surprisingly, at that time an occult breast carcinoma was identified to be the orig...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.11.008
更新日期:2004-05-01 00:00:00
abstract::We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces wer...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.020
更新日期:2017-03-01 00:00:00
abstract::Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopatho...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.02.013
更新日期:2004-06-01 00:00:00
abstract::The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.022
更新日期:2007-09-01 00:00:00