Use of antibodies to intermediate filaments in the diagnosis of metastatic amelanotic malignant melanoma.

Abstract:

:Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conventional staining with hematoxylin-eosin confirmed the melanocytic origin of the tumor, indicating that it was probably an amelanotic metastasis of the original malignant melanoma. The findings in this case demonstrate the potential usefulness of immunohistochemical microscopic characterization of specific intermediate filament proteins in the diagnosis of otherwise ambiguous cases of amelanotic melanoma.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Huszar M,Halkin H,Herczeg E,Bubis J,Geiger B

doi

10.1016/s0046-8177(83)80182-8

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

1006-8

issue

11

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(83)80182-8

journal_volume

14

pub_type

杂志文章
  • Disseminated infection with Lacazia loboi and immunopathology of the lesional spectrum.

    abstract::The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followe...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2014.10.016

    authors: Oliveira Carneiro FR,da Cunha Fischer TR,Brandão CM,Pagliari C,Duarte MI,Quaresma JA

    更新日期:2015-02-01 00:00:00

  • Giant cell tumor of tendon sheath is a polyclonal cellular proliferation.

    abstract::Giant cell tumor of tendon sheath (GCTTS) is a common soft tissue tumor. Immunophenotypical evidence suggests it is of synovial cell origin. There is controversy regarding the underlying nature of this lesion, specifically whether it is a neoplastic or nonneoplastic (ie, reactive or hyperplastic) process. Karyotypic a...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(97)90155-6

    authors: Vogrincic GS,O'Connell JX,Gilks CB

    更新日期:1997-07-01 00:00:00

  • Smad4 overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta II receptor immunolabeling.

    abstract::In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A loss of Smad4 is associated with carcinoma ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2002.128061

    authors: Torbenson M,Marinopoulos S,Dang DT,Choti M,Ashfaq R,Maitra A,Boitnott J,Wilentz RE

    更新日期:2002-09-01 00:00:00

  • An unintentional irony: the autopsy in modern medicine and society.

    abstract::Autopsy rates continue to decline despite abundant evidence of the autopsy's value. Such an extraordinary contradiction requires that we look beyond issues of education to consider our basic moral and political commitments; to consider, in other words, the kind of society in which we live, and the kind of people we ar...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(90)90121-k

    authors: Vance RP

    更新日期:1990-02-01 00:00:00

  • Expression of Sox2 in human cervical carcinogenesis.

    abstract::Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2009.11.021

    authors: Ji J,Zheng PS

    更新日期:2010-10-01 00:00:00

  • Recurrent "syncytial variant" of Hodgkin's disease: an immunohistologic diagnosis.

    abstract::A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(87)80247-2

    authors: Blaustein JC,Lewkow L

    更新日期:1987-07-01 00:00:00

  • Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells.

    abstract::Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2016.06.001

    authors: Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

    更新日期:2016-10-01 00:00:00

  • Testicular atrophy in AIDS: a study of 57 autopsy cases.

    abstract::The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(89)90125-1

    authors: De Paepe ME,Waxman M

    更新日期:1989-03-01 00:00:00

  • Using p16 immunohistochemistry to classify morphologic cervical intraepithelial neoplasia 2: correlation of ambiguous staining patterns with HPV subtypes and clinical outcome.

    abstract::p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2017.06.014

    authors: Liu Y,Alqatari M,Sultan K,Ye F,Gao D,Sigel K,Zhang D,Kalir T

    更新日期:2017-08-01 00:00:00

  • Atypical mesothelial hyperplasia associated with bronchogenic carcinoma.

    abstract::Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(91)90292-w

    authors: Yokoi T,Mark EJ

    更新日期:1991-07-01 00:00:00

  • Electron microscopic study of testicular tumor in congenital adrenal hyperplasia.

    abstract::Ultrastructural features of bilateral testicular biopsy materials, obtained from both tumor and nontumor areas of the testis of a 27-year-old man with congenital adrenal hyperplasia, revealed a number of pathologic changes. Germ cell hypoplasia and extratubular cellular hyperplasia were noticed in the nontumor portion...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(83)80244-5

    authors: Chakraborty J,Franco-Saenz R,Kropp K

    更新日期:1983-02-01 00:00:00

  • Paracoccidioides brasiliensis causing a rib lesion in an adult AIDS patient.

    abstract::Paracoccidioidomycosis is a systemic mycosis with a geographic distribution that is limited to Central and South America; Brazil has the highest number of cases. Severe disseminated disease caused by paracoccidioidomycosis was observed in acquired immunodeficiency syndrome patients who live or have resided in endemic ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2010.03.007

    authors: de Freitas RS,Dantas KC,Garcia RS,Magri MM,de Andrade HF Jr

    更新日期:2010-09-01 00:00:00

  • TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy.

    abstract::T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2016.12.030

    authors: Hu Z,Li S,Medeiros LJ,Sun T

    更新日期:2017-07-01 00:00:00

  • Bile duct carcinoma associated with multiple von Meyenburg complexes in the liver.

    abstract::A 61-year-old white woman was found to have disseminated abdominal carcinoma at autopsy. The primary site proved to be a bile duct carcinoma arising from ductal epithelium of multiple von Meyenburg complexes of the liver. No other neoplastic lesion was found elsewhere after careful, gross, microscopic examination. Thi...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(86)80575-5

    authors: Honda N,Cobb C,Lechago J

    更新日期:1986-12-01 00:00:00

  • Male breast cancer: a case of apocrine carcinoma with psammoma bodies.

    abstract::A case of apocrine carcinoma of the breast with psammoma bodies is described in a 69 year old man. The report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of psammoma bodies. ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(81)80178-5

    authors: Bryant J

    更新日期:1981-08-01 00:00:00

  • Systemic lupus erythematosus-associated neutrophilic dermatosis--an underrecognized neutrophilic dermatosis in patients with systemic lupus erythematosus.

    abstract::Neutrophilic dermatoses are an uncommon manifestation of lupus. We describe the clinical and histopathologic features of 14 patients with systemic lupus erythematosus (SLE) and neutrophilic dermatoses, 2 of whom had no prior history of SLE. Thirteen patients were female, ranging in age from 27 to 62 years (mean age, 4...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2013.10.029

    authors: Larson AR,Granter SR

    更新日期:2014-03-01 00:00:00

  • Pathology trainee manpower: APC program directors' questionnaire, 1989 results.

    abstract::The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(91)90258-q

    authors: Vance RP,Prichard RW,Smith RD

    更新日期:1991-11-01 00:00:00

  • Mallory bodies in scar adenocarcinoma of the lung.

    abstract::A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(82)80143-3

    authors: Michel RP,Limacher JJ,Kimoff RJ

    更新日期:1982-01-01 00:00:00

  • Intertubular growth in pure seminomas: associations with poor prognostic parameters.

    abstract::Clinical stage I seminomas are effectively treated with surgery raising concerns as to when to give adjuvant radiation therapy given the risk of secondary malignancies. A recent randomized trial found tumor size and rete testis invasion to be the strongest predictors of relapse in clinical stage I seminomas. These 2 p...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2005.03.011

    authors: Browne TJ,Richie JP,Gilligan TD,Rubin MA

    更新日期:2005-06-01 00:00:00

  • Primary pulmonary hyalinizing clear cell carcinoma of bronchial submucosal gland origin.

    abstract::Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2014.11.010

    authors: García JJ,Jin L,Jackson SB,Larsen BT,Lewis JE,Sukov WR,Roden AC

    更新日期:2015-03-01 00:00:00

  • The lymphoid system. Its normal architecture and the potential for understanding the system through the study of lymphoproliferative diseases.

    abstract::This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/s0046-8177(78)80005-7

    authors: Weissman IL,Warnke R,Butcher EC,Rouse R,Levy R

    更新日期:1978-01-01 00:00:00

  • Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma.

    abstract::Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2017.03.007

    authors: Wang H,Kohashi K,Yoshizumi T,Okumura Y,Tanaka Y,Shimokawa M,Iwasaki T,Aishima S,Maehara Y,Oda Y

    更新日期:2017-06-01 00:00:00

  • Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma.

    abstract::Syndecan-1, a cell-surface transmembrane heparan sulfate proteoglycan, has been reported to correlate with the biologic behavior of malignant tumors in various organs. We examined the correlation between the expression of syndecan-1 at the protein and mRNA levels and clinicopathologic features of 37 intrahepatic chola...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(03)00336-8

    authors: Harada K,Masuda S,Hirano M,Nakanuma Y

    更新日期:2003-09-01 00:00:00

  • High expression of CD34-positive sinusoidal endothelial cells is a risk factor for hepatocellular carcinoma in patients with HCV-associated chronic liver diseases.

    abstract::CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2001.29678

    authors: Ohmori S,Shiraki K,Sugimoto K,Sakai T,Fujikawa K,Wagayama H,Takase K,Nakano T

    更新日期:2001-12-01 00:00:00

  • Pathology data integration with eXtensible Markup Language.

    abstract::It is impossible to overstate the importance of XML (eXtensible Markup Language) as a data organization tool. With XML, pathologists can annotate all of their data (clinical and anatomic) in a format that can transform every pathology report into a database, without compromising narrative structure. The purpose of thi...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humpath.2004.10.013

    authors: Berman JJ

    更新日期:2005-02-01 00:00:00

  • Choriocarcinoma following a partial hydatidiform mole: a case report.

    abstract::Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblasti...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(92)90096-l

    authors: Gardner HA,Lage JM

    更新日期:1992-04-01 00:00:00

  • Clear cell sarcoma of tendons and aponeuroses: electron microscopic findings suggesting Schwann cell differentiation.

    abstract::A case of clear cell sarcoma of tendons and aponeuroses arising in the elbow of a young woman is reported. Local recurrence and lymph node metastases occurred despite radiation therapy, chemotherapy, and amputation of the right arm, and the patient died of the tumor approximately ten months after the initial diagnosis...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(83)80267-6

    authors: Azumi N,Turner RR

    更新日期:1983-12-01 00:00:00

  • Elastofibroma dorsi: an immunochemical study of collagen content.

    abstract::The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(81)80107-4

    authors: Madri JA,Dise CA,LiVolsi VA,Merino MJ,Bibro MC

    更新日期:1981-02-01 00:00:00

  • Extrahepatic biliary obstruction and liver failure secondary to myeloma of the pancreas.

    abstract::An unusual case of multiple myeloma in an 88-year-old patient is described. Besides skeletal involvement, there was myeloma of the thoracic and abdominal lymph nodes and of the liver and pancreas. In the pancreas, the myeloma extensively involved the head and body, and on computerized tomography scan was suggestive of...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(82)80057-9

    authors: Bell HG,David R,Shamsuddin AM

    更新日期:1982-10-01 00:00:00

  • Synchronous ductal carcinoma in situ of the breast and within epithelial inclusions in an ipsilateral sentinel lymph node.

    abstract::Epithelial inclusions in the axillary lymph nodes are very rare and have even less commonly been reported with either benign or malignant changes. We present a case of synchronous high-grade micropapillary ductal carcinoma in situ arising in the breast and in an epithelial inclusion in an ipsilateral sentinel lymph no...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2012.07.012

    authors: Fitzpatrick-Swallow VL,Helin H,Cane P,Pinder SE

    更新日期:2013-01-01 00:00:00