Expression of Bfl-1 in normal and tumor tissues: Bfl-1 overexpression in cancer is attributable to its preferential expression in infiltrating inflammatory cells.

Abstract:

:Bfl-1, a member of the Bcl-2 gene family, blocks p53-mediated apoptosis and has oncogenic transforming activity. In normal tissues, the transcript of Bfl-1 is expressed abundantly in bone marrow and at a low level in several other tissues. In previous experiments, elevated expression of Bfl-1 was observed by Northern analysis of stomach cancer samples. To study the role of Bfl-1 in normal cell development and in tumorigenesis, we have analyzed the expression of Bfl-1 in normal and tumor tissues by the in situ hybridization technique. The Bfl-1 transcript was detected in the white pulp of the spleen and in the germinal center of lymphatic tissues. In tumor tissues, its expression was preferentially detected in infiltrating inflammatory cells rather than in cancer cells, suggesting that Bfl-1 is not involved in tumorigenesis.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Jung-Ha H,Kim D,Lee SB,Hong SI,Park SY,Huh J,Kim CW,Kim SS,Lee Y,Choi SS,Shin HS

doi

10.1016/s0046-8177(98)90282-9

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

723-8

issue

7

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(98)90282-9

journal_volume

29

pub_type

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