Abstract:
:Bfl-1, a member of the Bcl-2 gene family, blocks p53-mediated apoptosis and has oncogenic transforming activity. In normal tissues, the transcript of Bfl-1 is expressed abundantly in bone marrow and at a low level in several other tissues. In previous experiments, elevated expression of Bfl-1 was observed by Northern analysis of stomach cancer samples. To study the role of Bfl-1 in normal cell development and in tumorigenesis, we have analyzed the expression of Bfl-1 in normal and tumor tissues by the in situ hybridization technique. The Bfl-1 transcript was detected in the white pulp of the spleen and in the germinal center of lymphatic tissues. In tumor tissues, its expression was preferentially detected in infiltrating inflammatory cells rather than in cancer cells, suggesting that Bfl-1 is not involved in tumorigenesis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Jung-Ha H,Kim D,Lee SB,Hong SI,Park SY,Huh J,Kim CW,Kim SS,Lee Y,Choi SS,Shin HSdoi
10.1016/s0046-8177(98)90282-9subject
Has Abstractpub_date
1998-07-01 00:00:00pages
723-8issue
7eissn
0046-8177issn
1532-8392pii
S0046-8177(98)90282-9journal_volume
29pub_type
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