Expression of Bfl-1 in normal and tumor tissues: Bfl-1 overexpression in cancer is attributable to its preferential expression in infiltrating inflammatory cells.


:Bfl-1, a member of the Bcl-2 gene family, blocks p53-mediated apoptosis and has oncogenic transforming activity. In normal tissues, the transcript of Bfl-1 is expressed abundantly in bone marrow and at a low level in several other tissues. In previous experiments, elevated expression of Bfl-1 was observed by Northern analysis of stomach cancer samples. To study the role of Bfl-1 in normal cell development and in tumorigenesis, we have analyzed the expression of Bfl-1 in normal and tumor tissues by the in situ hybridization technique. The Bfl-1 transcript was detected in the white pulp of the spleen and in the germinal center of lymphatic tissues. In tumor tissues, its expression was preferentially detected in infiltrating inflammatory cells rather than in cancer cells, suggesting that Bfl-1 is not involved in tumorigenesis.


Hum Pathol


Human pathology


Jung-Ha H,Kim D,Lee SB,Hong SI,Park SY,Huh J,Kim CW,Kim SS,Lee Y,Choi SS,Shin HS




Has Abstract


1998-07-01 00:00:00














  • High interlaboratory and interobserver agreement of somatostatin receptor immunohistochemical determination and correlation with response to somatostatin analogs.

    abstract::Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation has yet to...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kasajima A,Papotti M,Ito W,Brizzi MP,La Salvia A,Rapa I,Tachibana T,Yazdani S,Sasano H,Volante M

    更新日期:2018-02-01 00:00:00

  • Solitary fibrous tumors of the head and neck region revisited: a single-institution study of 20 cases and review of the literature.

    abstract::A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Baněčková M,Martínek P,Skálová A,Mezencev R,Hadravský L,Michal M,Švajdler M

    更新日期:2020-05-01 00:00:00

  • Immunohistochemistry of human cutaneous sarcoidosis: a study of nine cases.

    abstract::Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and it...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kataria YP,Zafranas A,Sharma HM

    更新日期:1978-09-01 00:00:00

  • Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells.

    abstract::A 60-year-old man developed a widely metastatic spindle cell neoplasm with admixed osteoclast-like giant cells indistinguishable from malignant giant cell tumor of soft parts. Autopsy revealed a bronchogenic sarcomatoid squamous cell carcinoma that was the primary source of the sarcomatoid metastases. The osteoclast-l...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Love GL,Daroca PJ Jr

    更新日期:1983-11-01 00:00:00

  • Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma: an immunohistologic, ultrastructural, and cytogenetic study.

    abstract::Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examina...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Saw D,Chan JK,Jagirdar J,Greco MA,Lee M

    更新日期:1992-08-01 00:00:00

  • The cardiac malformations. Double inlet left ventricle and corrected transposition explained as deviations in the normal development of the interventricular septum.

    abstract::To examine the hypothesis that malpositions of cardiac ventricles could be explained by altered development of the interventricular septum, we studied hearts from the Johns Hopkins Hospital autopsy files with double inlet left ventricle (16 cases) or corrected transposition (nine cases). In double inlet left ventricle...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Hutchins GM,Meredith MA,Moore GW

    更新日期:1981-03-01 00:00:00

  • Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets.

    abstract::Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tan J,Sidhu G,Greco MA,Ballard H,Wieczorek R

    更新日期:1998-04-01 00:00:00

  • Apocrine cystic metaplasia: subgross pathology and prevalence in cancer-associated versus random autopsy breasts.

    abstract::Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contra...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Wellings SR,Alpers CE

    更新日期:1987-04-01 00:00:00

  • High expression of CD34-positive sinusoidal endothelial cells is a risk factor for hepatocellular carcinoma in patients with HCV-associated chronic liver diseases.

    abstract::CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ohmori S,Shiraki K,Sugimoto K,Sakai T,Fujikawa K,Wagayama H,Takase K,Nakano T

    更新日期:2001-12-01 00:00:00

  • Pseudomyogenic hemangioendothelioma of skin, bone and soft tissue-a clinicopathological, immunohistochemical, and fluorescence in situ hybridization study.

    abstract::Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Pradhan D,Schoedel K,McGough RL,Ranganathan S,Rao UNM

    更新日期:2018-01-01 00:00:00

  • Less utilization of the clinical laboratory produces disproportionately small true cost reductions.

    abstract::Decreases in true expenses in the hospital clinical laboratory consequent to reduced utilization were estimated from four models. Each category of direct expense was adjusted according to projections and confirmed to the extent possible by actual experience. No projections of reductions in indirect expenses were made....

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Winkelman JW

    更新日期:1984-06-01 00:00:00

  • Neurofibromin protein loss in desmoplastic melanoma subtypes: implicating NF1 allelic loss as a distinct genetic driver?

    abstract::Loss of the NF1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene RET (RETp) are purportedly common in desmoplastic melanoma (DM). DM is categorized into pure (PDM) and mixed (MDM) subtypes, which differ in prognosis. Most NF1 mutations result in a truncated/absent protein, making im...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kadokura A,Frydenlund N,Leone DA,Yang S,Hoang MP,Deng A,Hernandez-Perez M,Biswas A,Singh R,Yaar R,Mahalingam M

    更新日期:2016-07-01 00:00:00

  • Cutaneous and mammary apocrine carcinomas have different immunoprofiles.

    abstract::Often the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both tumors share similar histologic features and have overlapping immunohistochemical profile. We compared the expression of adipophilin, cytokeratin 5/6, p63, GATA3, mammag...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Piris A,Peng Y,Boussahmain C,Essary LR,Gudewicz TM,Hoang MP

    更新日期:2014-02-01 00:00:00

  • Fibrosis is worse in HIV-HCV patients with low-level immunodepression referred for HCV treatment than in HCV-matched patients.

    abstract::Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Rullier A,Trimoulet P,Neau D,Bernard PH,Foucher J,Lacoste D,Winnock M,Urbaniak R,Ballardini G,Balabaud C,Bioulac-Sage P,Le Bail B

    更新日期:2004-09-01 00:00:00

  • "Thanatosomes": a unifying morphogenetic concept for tumor hyaline globules related to apoptosis.

    abstract::Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Papadimitriou JC,Drachenberg CB,Brenner DS,Newkirk C,Trump BF,Silverberg SG

    更新日期:2000-12-01 00:00:00

  • Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.

    abstract::DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze DNA methyltransferase expression by immunohistochemistry in a series of 94 Tunisian sporadic breast carcinomas. Re...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ben Gacem R,Hachana M,Ziadi S,Ben Abdelkarim S,Hidar S,Trimeche M

    更新日期:2012-10-01 00:00:00

  • Use of antibodies to intermediate filaments in the diagnosis of metastatic amelanotic malignant melanoma.

    abstract::Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conven...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Huszar M,Halkin H,Herczeg E,Bubis J,Geiger B

    更新日期:1983-11-01 00:00:00

  • Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma.

    abstract::Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and β-catenin expression measured by immunohi...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Cheng Y,Zhou Y,Jiang W,Yang X,Zhu J,Feng D,Wei Y,Li M,Yao F,Hu W,Xiao W,Ling B

    更新日期:2012-08-01 00:00:00

  • Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement.

    abstract::Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Matsuoka K,Hayashi S,Urano F,Zhu LJ,Okita H,Sago H,Nakazawa A

    更新日期:2012-09-01 00:00:00

  • Symposium on pathology of the gastrointestinal tract-Part II. Small intestinal biopsy.

    abstract::A practical approach to the interpretation of peroral small intestinal biopsy specimens is presented. Biopsy technique and tissure handling are described. Interpretation of normal and abnormal biopsy specimens is discussed. A practical classification of abnormal small intestinal biopsies is presented and illustrated. ...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Perera DR,Weinstein WM,Rubin CE

    更新日期:1975-03-01 00:00:00

  • Hydrophilic polymer embolism and associated vasculopathy of the lung: prevalence in a retrospective autopsy study.

    abstract::Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Mehta RI,Mehta RI,Choi JM,Mukherjee A,Castellani RJ

    更新日期:2015-02-01 00:00:00

  • Up-regulation of long noncoding RNA M26317 correlates with tumor progression and poor prognosis in gastric cancer.

    abstract::To investigate the expression and clinical significance of long noncoding RNA (lncRNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein-coding genes and lncRNAs in tumor and paired adjacent nontumor tissues. We found that 41 lncRNAs were up-regulated and 31 lncRNAs were down-r...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Li L,Wang YY,Mou XZ,Ye ZY,Zhao ZS

    更新日期:2018-08-01 00:00:00

  • Visceral botryomycosis in a case of Erysipelothrix rhusiopathiae endocarditis.

    abstract::Botryomycosis is a rare bacterial infection of the skin and, rarely, viscera that is characterized by the formation of characteristic hyaline grains. We encountered a patient with Erysipelothrix rhusiopathiae endocarditis who developed visceral botryomycosis. He was a 54-year-old black man who presented in sepsis with...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Carson HJ,Perkins JT

    更新日期:2005-01-01 00:00:00

  • Pseudogynecomastia due to neurofibromatosis--a light microscopic and ultrastructural study.

    abstract::A six year old boy with bilateral breast enlargement was found to have a normal endocrine status. Resected tissue revealed the features of pseudogynecomastia due to a proliferation of fibrous tissue traversed by neuroid structures. Multinucleated giant cells were present within the fibrous tissue. Ultrastructural stud...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lipper S,Willson CF,Copeland KC

    更新日期:1981-08-01 00:00:00

  • Early apoptosis in human myocardial infarcts.

    abstract::Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Veinot JP,Gattinger DA,Fliss H

    更新日期:1997-04-01 00:00:00

  • Cluster analysis of the metastatic patterns of human immunodeficiency virus-associated Kaposi's sarcoma.

    abstract::Kaposi's sarcoma (KS) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (HIV), especially among those whose primary risk factor is homo/bisexual transmission. The question as to whether KS is even a true neoplasm still remains larg...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lee WA,Hutchins GM

    更新日期:1992-03-01 00:00:00

  • Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications.

    abstract::In this autopsy series of cryptococcal meningoencephalitis (CME), the authors analyzed neuropathologic lesions in 13 human immunodeficiency virus (HIV) and 14 non-HIV-related cases. Most non-HIV patients did not have immunosuppressive predisposing illness. Analysis of pathological findings revealed significant differe...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lee SC,Dickson DW,Casadevall A

    更新日期:1996-08-01 00:00:00

  • Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features.

    abstract::Renal cell carcinoma (RCC) with sarcomatoid changes and rhabdoid features has shown poor outcomes. Several immune checkpoint inhibitors including programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors have been approved for the treatment of RCC. Combination therapy using PD-1/PD-L1 and ind...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kiyozawa D,Takamatsu D,Kohashi K,Kinoshita F,Ishihara S,Toda Y,Eto M,Oda Y

    更新日期:2020-07-01 00:00:00

  • Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinoma.

    abstract::Galectins, a family of beta-galactoside-binding animal lectins, might be involved in tumor progression. In this study, the expression patterns of galectin-1 and -3 were examined immunohistochemically in intrahepatic cholangiocarcinoma (ICC), with emphasis on its development and progression as well as its histopatholog...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Shimonishi T,Miyazaki K,Kono N,Sabit H,Tuneyama K,Harada K,Hirabayashi J,Kasai K,Nakanuma Y

    更新日期:2001-03-01 00:00:00

  • Rituximab treatment circumvents the prognostic impact of tumor-infiltrating T-cells in follicular lymphoma patients.

    abstract::Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantifi...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Xerri L,Huet S,Venstrom JM,Szafer-Glusman E,Fabiani B,Canioni D,Chassagne-Clément C,Dartigues-Cuilléres P,Charlotte F,Laurent C,Gelas-Dore B,Bolen CR,Punnoose E,Bouabdallah R,Brice P,Morschhauser F,Cartron G,Olive D,S

    更新日期:2017-06-01 00:00:00