Abstract:
:Many have wondered what might have become of the totalitarian state Lenin founded on merciless terror, had he not died so young. He was 52 and at the height of his power when he had his first stroke. Six months later he had another and then a third stroke three months after that. He died 3 months shy of his 54th birthday with cerebral arteries so calcified that when tapped with tweezers at the time of his autopsy, they sounded like stone. The reason for his premature atherosclerosis has yet to be explained. He had a family history of cardiovascular disease and, therefore, is suspected of having had an inherited lipid disorder. Stress too might have had a role in the progression of his atherosclerosis. However, neither would explain the extent of the calcification of his cerebral arteries identified at post mortem examination. A recently described variant of the NT5E mutation might explain such calcification, as well as Lenin's family history of cardiovascular disease, and his premature cerebrovascular attacks.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Vinters H,Lurie L,Mackowiak PAdoi
10.1016/j.humpath.2012.11.017subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1967-72issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(12)00445-5journal_volume
44pub_type
传,历史文章,杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.10.008
更新日期:2011-07-01 00:00:00
abstract::Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lym...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.08.009
更新日期:2007-02-01 00:00:00
abstract::Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues. We aimed to assess the prevalence of CA9 expression and its prognostic implications in patients with oral cavity sq...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.026
更新日期:2008-09-01 00:00:00
abstract::The light microscopic diagnosis of large cell undifferentiated carcinoma of the lung is known to be highly subjective and shows poor interobserver reproducibility; the very existence of this tumor as a separate entity has been challenged. The ultrastructure of seven large cell undifferentiated carcinomas was examined ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80105-1
更新日期:1978-03-01 00:00:00
abstract::The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.07.016
更新日期:2005-10-01 00:00:00
abstract::We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.12.010
更新日期:2007-06-01 00:00:00
abstract::Lymphocytic colitis, previously termed "microscopic colitis", is a clinicopathologic syndrome of watery diarrhea, grossly normal colonoscopy, and mucosal inflammatory changes. Since lymphocytic colitis is a new, incompletely characterized entity, a histopathologic study was performed to compare lymphocytic colitis (n ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90198-6
更新日期:1989-01-01 00:00:00
abstract::Fifty-three pure mucinous carcinomas of breast were studied, with long-term follow-up evaluation (average, 15 years) for 37. The mean age of the patients was 63 years. Long-term survival (Kaplan-Meier method) was 68 per cent, excluding non-tumor-related deaths. Median survival for the patients with fatal carcinomas wa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80152-6
更新日期:1986-01-01 00:00:00
abstract::It has been suggested that inferences about fetal karyotype can be made from examination of placental and decidual histology in early, spontaneous abortions (SABs). We assessed the reproducibility and predictive value of histologic features in 75 karyotyped, first trimester SABs; 32% (24 of 75) had normal male karyoty...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90038-1
更新日期:1995-02-01 00:00:00
abstract::Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90124-7
更新日期:1999-04-01 00:00:00
abstract::Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90215-3
更新日期:1993-11-01 00:00:00
abstract::Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were stu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90094-4
更新日期:1989-09-01 00:00:00
abstract::Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90185-4
更新日期:1997-06-01 00:00:00
abstract::Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.03.012
更新日期:2011-10-01 00:00:00
abstract::We report the case of an exuberant ulcerative angiomatoid nasal lesion in a cocaine abuser. The lesion was made up of polymorphous endothelial cells with occasional mitoses, arranged in a lobular pattern with infiltrative-looking areas. There were extensive areas of thrombosis with focal recanalization. Intravascular ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80226-9
更新日期:2000-02-01 00:00:00
abstract::The reticulin stain is a critical diagnostic aide used to differentiate benign hepatocellular proliferations from well differentiated hepatocellular carcinoma (HCC). Rarely, however, hepatocellular carcinomas do not show definitive loss of reticulin in liver biopsy specimens. To study this group of tumors, 11 HCC with...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.09.015
更新日期:2021-01-01 00:00:00
abstract::Perineural invasion is a histologic feature usually diagnostic of invasion in malignancies. In the breast, however, it has been associated with benign lesions such as sclerosing adenosis (SA), complex sclerosing lesion/radial scar (CSL/RS), and ductal carcinoma in situ (DCIS). This article describes perineural invasio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.27637
更新日期:2001-08-01 00:00:00
abstract::Cellular crescents are typically inflammatory and associated with rapidly progressive glomerulonephritis. Their pathogenesis involves glomerular basement membrane rupture due to circulating or intrinsic factors. Crescents associated with diabetic glomerulosclerosis are rarely reported. Furthermore, the nature of cells...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.030
更新日期:2014-03-01 00:00:00
abstract::This report describes a 47-year-old man with Erdheim-Chester disease (EC), the second case reported in Japan. The patient complained of knee pain, and the roentgenogram of the bilateral legs revealed symmetric osteolytic lesions with sclerosis of the metaphyseal regions of the long bones. Histological examination of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90145-8
更新日期:1996-01-01 00:00:00
abstract::We introduce a novel hybrid telepathology system providing simultaneous transmission of both real-time microscopy and static imagery at a reasonable cost. It is capable of capturing static, true color images at resolution of 1,520 x 1,144 pixels and providing live transmission of real-time video images of the glass sl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.9196
更新日期:2000-07-01 00:00:00
abstract::Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90041-m
更新日期:1991-02-01 00:00:00
abstract::Congenital syphilis is often a presumptive diagnosis (based on serologies), because confirmation requires identification of Treponema pallidum in fetal/neonatal tissues or in the placenta. Placental histological features associated with congenital syphilis include the triad of enlarged hypercellular villi, proliferati...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90110-0
更新日期:1996-04-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.032
更新日期:2011-04-17 00:00:00
abstract::We aimed to study the expression of phosphorylated vascular endothelial growth factor receptor 2 (pVEGFR-2), a membrane-bound tyrosine kinase receptor to vascular endothelial growth factor, in 76 cases of leukemia and nonneoplastic myeloproliferative disease and in 8 reactive bone marrows. The microvessel density (MVD...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.05.015
更新日期:2005-07-01 00:00:00
abstract::Strategies for cost containment in the clinical laboratory have been proposed and some are being tested. An approach is described and illustrated in this article for estimating the size of a cost reduction that might be observed in response to hypothetical changes in the utilization of the clinical laboratory. The var...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(80)80051-7
更新日期:1980-09-01 00:00:00
abstract::Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations pr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.06.003
更新日期:2014-09-01 00:00:00
abstract::Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.002
更新日期:2015-03-01 00:00:00
abstract::The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic b...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.02.001
更新日期:2006-07-01 00:00:00
abstract::Endometrial carcinoma is the most common invasive malignancy of the female genital tract, and it exists as two different clinicopathologic forms: an estrogen-dependent, "usual" type and an estrogen-independent "special variant" type. Despite the frequency of endometrial cancer, little is known about the molecular gene...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90084-8
更新日期:1997-05-01 00:00:00
abstract::Recently, a polymorphism in the hMSH2 DNA mismatch repair gene has been associated with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of interest because DNA mismatch repair defects result in alterations in microsatellite stability. The current study was designed to determine w...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90293-9
更新日期:1999-01-01 00:00:00