An approach to studying the cost behavior of changing utilization of a hospital laboratory.

abstract：:HMGB2 is an important protein in carcinogenesis. However, little is known about the specific role of HMGB2 in gastric cancer. In the present study, HMGB2 expression was evaluated in 198 primary gastric cancer tissues and their adjacent nontumor controls. The correlation between HMGB2 expression and clinico-pathologica...

journal_title：Human pathology

authors： Cui G,Cai F,Ding Z,Gao L

更新日期：2019-02-01 00:00:00

abstract：:Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bon...

journal_title：Human pathology

authors： Hibi S,Esumi N,Todo S,Imashuku S

更新日期：1988-06-01 00:00:00

abstract：:Clinicopathologic records and neuropathologic tissues of 109 patients who underwent necropsy after treatment with bone marrow transplantation (BMT) were examined. Underlying disorders included leukemia (70), aplastic anemia (25), solid tumors (7), lymphoma (5), Hodgkin's disease (1) and Wiskott-Aldrich syndrome (1). T...

journal_title：Human pathology

authors： Mohrmann RL,Mah V,Vinters HV

更新日期：1990-06-01 00:00:00

abstract：:The Sydney classification for gastritis provides guidelines for histological grading of gastric biopsies. In an ongoing study of gastric preneoplastic lesions in Chiapas, Mexico, 7 biopsies from 150 patients (4 from the antrum and 3 from the body) were obtained during endoscopy and studied histologically. The first 74...

journal_title：Human pathology

authors： Guarner J,Herrera-Goepfert R,Mohar A,Sanchez L,Halperin D,Ley C,Parsonnet J

更新日期：1999-12-01 00:00:00

abstract：:Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen productio...

journal_title：Human pathology

authors： Azmahani A,Nakamura Y,Ozawa Y,McNamara KM,Fujimura T,Haga T,Hashimoto A,Aiba S,Sasano H

更新日期：2015-11-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...

journal_title：Human pathology

authors： Malgulwar PB,Nambirajan A,Pathak P,Rajeshwari M,Suri V,Sarkar C,Singh M,Sharma MC

更新日期：2018-12-01 00:00:00

abstract：:The neuropathologic findings in the spinal cord were reviewed in 138 consecutive autopsies of patients with the acquired immunodeficiency syndrome. In all cases both the brain and spinal cord were examined by conventional histologic techniques, and in 63 cases immunohistochemistry was used to detect human immunodefici...

journal_title：Human pathology

authors： Hénin D,Smith TW,De Girolami U,Sughayer M,Hauw JJ

更新日期：1992-10-01 00:00:00

abstract：:Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...

journal_title：Human pathology

authors： Tsutsumi Y

更新日期：1989-09-01 00:00:00

abstract：:Five hundred consecutive breast carcinomas from the first screening round of the Breast Cancer Detection Demonstration Project were studied quantitatively and semiquantitatively for features relevant to the diagnosis of tubular carcinoma. Tubularity was defined as the proportion of tumor cells that were adjacent to an...

journal_title：Human pathology

authors： Stalsberg H,Hartmann WH

更新日期：2000-05-01 00:00:00

abstract：:A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age...

journal_title：Human pathology

authors： Ciscato A,Zare SY,Fadare O

更新日期：2020-06-01 00:00:00

abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

journal_title：Human pathology

authors： Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

更新日期：1999-04-01 00:00:00

abstract：:Ultrastructural features of bilateral testicular biopsy materials, obtained from both tumor and nontumor areas of the testis of a 27-year-old man with congenital adrenal hyperplasia, revealed a number of pathologic changes. Germ cell hypoplasia and extratubular cellular hyperplasia were noticed in the nontumor portion...

journal_title：Human pathology

authors： Chakraborty J,Franco-Saenz R,Kropp K

更新日期：1983-02-01 00:00:00

abstract：:Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

journal_title：Human pathology

authors： Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

更新日期：2016-10-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...

journal_title：Human pathology

authors： Di Sabatino A,Rovedatti L,Rosado MM,Carsetti R,Corazza GR,MacDonald TT

更新日期：2009-05-01 00:00:00

abstract：:The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...

journal_title：Human pathology

authors： Conde E,Suarez-Gauthier A,García-García E,Lopez-Rios F,Lopez-Encuentra A,García-Lujan R,Morente M,Sanchez-Verde L,Sanchez-Cespedes M

更新日期：2007-09-01 00:00:00

abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...

journal_title：Human pathology

authors： El-Zimaity HM,Graham DY

更新日期：1999-01-01 00:00:00

abstract：:Spindle cell squamous esophageal carcinomas are distinctive polypoid "biphasic" tumors in which the sarcoma-like phenotype usually predominates over the epithelial component. To biologically assess both phenotypes, we compared the tumoral proliferative activity and DNA ploidy between the two histological components of...

journal_title：Human pathology

authors： Lauwers GY,Grant LD,Scott GV,Carr NJ,Sobin LH

更新日期：1998-08-01 00:00:00

abstract：:The aim of the study was to evaluate the impact of the updated 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline on human epidermal growth factor receptor 2 (HER2) interpretation in breast cancer compared with that of the previous guidelines and also the significance of...

journal_title：Human pathology

authors： Woo JW,Lee K,Chung YR,Jang MH,Ahn S,Park SY

更新日期：2020-04-01 00:00:00

abstract：:Fifty-three pure mucinous carcinomas of breast were studied, with long-term follow-up evaluation (average, 15 years) for 37. The mean age of the patients was 63 years. Long-term survival (Kaplan-Meier method) was 68 per cent, excluding non-tumor-related deaths. Median survival for the patients with fatal carcinomas wa...

journal_title：Human pathology

authors： Clayton F

更新日期：1986-01-01 00:00:00

abstract：:The Mix1 homeobox-like (MIXL1) gene encodes a paired class homeobox transcription factor that is involved in embryogenesis. Previous studies have shown that the MIXL1 gene product is expressed in B- and T-cell progenitors of normal bone marrow and, in some cell lines derived from hematopoietic neoplasms. The status of...

journal_title：Human pathology

authors： Drakos E,Rassidakis GZ,Leventaki V,Guo W,Medeiros LJ,Nagarajan L

更新日期：2007-03-01 00:00:00

abstract：:Breast cancer is the leading form of cancer diagnosed in women, and the second leading cause of cancer mortality in this group. A commonly accepted grading system for breast cancer that has proven useful for guiding treatment strategy is the modified Bloom-Richardson system. However, this system is subject to interobs...

journal_title：Human pathology

authors： Tambasco M,Magliocco AM

更新日期：2008-05-01 00:00:00

abstract：:T-lymphocyte subsets in peripheral blood, bronchoalveolar lavage fluid, and prescalenic lymph nodes from eight patients with sarcoidosis were evaluated with monoclonal antibodies. Both in lung and lymph nodes significant increases in helper T cells were demonstrated, except in patients with stage III pulmonary disease...

journal_title：Human pathology

authors： Viale G,Codecasa L,Bulgheroni P,Giobbi A,Madonini E,Dell'Orto P,Coggi G

更新日期：1986-05-01 00:00:00

abstract：:Gene hypomethylation and hypermethylation can lead to a loss of genetic imprinting in malignancies. The mechanism responsible for overexpression of the imprinted insulin-like growth factor II (IGF2) gene has not been investigated in osteosarcoma. In this study, the expression levels, imprinting status, and the extent ...

journal_title：Human pathology

authors： Li Y,Meng G,Huang L,Guo QN

更新日期：2009-10-01 00:00:00

abstract：:We applied a panel of antibodies to formalin-fixed, paraffin-embedded sections of 55 renal cell carcinomas using a three-stage immunoperoxidase technique. The antibody panel included two anti-keratins, AE1 and CAM5.2, anti-epithelial membrane antigen (EMA), anti-vimentin, anti-S100 protein, and the anti-leukocyte mark...

journal_title：Human pathology

authors： Medeiros LJ,Michie SA,Johnson DE,Warnke RA,Weiss LM

更新日期：1988-08-01 00:00:00

abstract：:Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a h...

journal_title：Human pathology

authors： Keifer J,Zaino R,Ballard JO

更新日期：1984-11-01 00:00:00

abstract：:The number of opportunistic infections in the central nervous system (CNS) has been steadily increasing because of a rising number of immunocompromised patients. A rare form of CNS infection can be caused by Chaetomium species, one of the largest genera of saprophytic ascomycetes. The CNS lesions in the present case w...

journal_title：Human pathology

authors： Thomas C,Mileusnic D,Carey RB,Kampert M,Anderson D

更新日期：1999-07-01 00:00:00

abstract：:Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantifi...

journal_title：Human pathology

authors： Xerri L,Huet S,Venstrom JM,Szafer-Glusman E,Fabiani B,Canioni D,Chassagne-Clément C,Dartigues-Cuilléres P,Charlotte F,Laurent C,Gelas-Dore B,Bolen CR,Punnoose E,Bouabdallah R,Brice P,Morschhauser F,Cartron G,Olive D,S

更新日期：2017-06-01 00:00:00

abstract：:Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...

journal_title：Human pathology

authors： Jhuang JY,Chang ST,Weng SF,Pan ST,Chu PY,Hsieh PP,Wei CH,Chou SC,Koo CL,Chen CJ,Hsu JD,Chuang SS

更新日期：2015-02-01 00:00:00

abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...

journal_title：Human pathology

authors： Wang H,Kohashi K,Yoshizumi T,Okumura Y,Tanaka Y,Shimokawa M,Iwasaki T,Aishima S,Maehara Y,Oda Y

更新日期：2017-06-01 00:00:00

abstract：:Rhabdomyomas are rare tumors that usually arise within the heart, orocervical, or vulvovaginal regions. The cardiac tumors have a characteristic immature morphology, occur often in association with tuberous sclerosis, and are regarded as hamartomas rather than true neoplasms. The histogenesis of the extracardiac tumor...

journal_title：Human pathology

authors： Zwick DL,Livingston K,Clapp L,Kosnik E,Yates A

更新日期：1989-04-01 00:00:00