Abstract:
:The neuropathologic findings in the spinal cord were reviewed in 138 consecutive autopsies of patients with the acquired immunodeficiency syndrome. In all cases both the brain and spinal cord were examined by conventional histologic techniques, and in 63 cases immunohistochemistry was used to detect human immunodeficiency virus (HIV), Toxoplasma gondii, cytomegalovirus, and JC papovavirus antigens. The most common observation was a normal spinal cord (60%). Vacuolar myelopathy (VM) was observed in 23 (17%) cases. Human immunodeficiency virus myelitis was evident in 8% of cases. Human immunodeficiency virus myelitis was associated with HIV encephalitis in 65% of the cases. Opportunistic infections of the spinal cord were uncommon, consisting of cryptococcosis (five cases), cytomegalovirus (four cases), toxoplasmosis (one case), and progressive multifocal leukoencephalopathy (one case), and almost always were seen with cerebral and/or systemic infection by these agents. Malignant lymphoma rarely involved the spinal cord (four cases); all were B-cell lymphomas and were associated with cerebral and/or systemic lymphoma. Other abnormalities rarely observed were Wallerian degeneration of the corticospinal tracts or posterior columns (6%) and focal microinfarcts. Most cases of VM (78%) were not associated with HIV myelitis, and in the five patients with both VM and HIV myelitis, HIV-infected cells were not found in the regions affected by VM. In contrast, 65% of cases with VM were associated with HIV encephalitis. The pathogenesis of VM remains unknown; it is probably not due to direct infection by HIV.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Hénin D,Smith TW,De Girolami U,Sughayer M,Hauw JJdoi
10.1016/0046-8177(92)90028-2subject
Has Abstractpub_date
1992-10-01 00:00:00pages
1106-14issue
10eissn
0046-8177issn
1532-8392pii
0046-8177(92)90028-2journal_volume
23pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::It is impossible to overstate the importance of XML (eXtensible Markup Language) as a data organization tool. With XML, pathologists can annotate all of their data (clinical and anatomic) in a format that can transform every pathology report into a database, without compromising narrative structure. The purpose of thi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2004.10.013
更新日期:2005-02-01 00:00:00
abstract::To investigate the possibility of human immunodeficiency virus-(HIV) 1 infection of liver cells, liver samples from 17 patients with either acquired immunodeficiency syndrome (AIDS, 13), AIDS-related complex (ARC, 3), or lymphadenopathy syndrome (LAS, 1) were studied. A monoclonal antibody directed against the p24 gag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90202-g
更新日期:1990-04-01 00:00:00
abstract::Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.033
更新日期:2017-10-01 00:00:00
abstract::Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90251-3
更新日期:1997-10-01 00:00:00
abstract::Wild type p53 plays a crucial role in maintaining genomic stability in both normal and tumor cells in vitro. When DNA damage occurs, p53 acts as a cell cycle checkpoint and induces a cellular response that aims at restoring genomic integrity. p53 may either allow the repair of damaged DNA by inducing a transient G1 ar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90292-9
更新日期:1995-12-01 00:00:00
abstract::Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90161-h
更新日期:1991-03-01 00:00:00
abstract::Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical, and expansile lesion with variable margins. Histologically, adamantinoma is a bimorphic neoplasm, composed of epithelial and ost...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.11.018
更新日期:2019-09-01 00:00:00
abstract::Promyelocytic leukemia zinc finger is a zinc finger transcription factor that functions as a transcriptional repressor. Its expression has been shown to be down-regulated in hematopoietic, melanocytic, and mesothelial malignancies. Histone H1.5 is a variant of histone H1, a family of linker proteins that organizes chr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.11.014
更新日期:2013-07-01 00:00:00
abstract::The distinction of malignant mesothelioma from non-small-cell lung carcinoma (NSCLC) usually requires immunohistochemistry, but some broad-spectrum carcinoma markers stain mesotheliomas, and it remains unclear which broad-spectrum markers are most valuable for distinguishing these malignancies. Here, we directly compa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.04.005
更新日期:2020-06-01 00:00:00
abstract::Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.021
更新日期:2010-10-01 00:00:00
abstract::In the past few years many clinically significant new glomerular lesions have been reported from observations made on renal biopsy specimens by electron microscopy. The clinical applicability of electron microscopy is illustrated by examples of specific ultrastructural patterns of glomerular reaction making possible a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(75)80060-8
更新日期:1975-07-01 00:00:00
abstract::We investigated whether histological chorioamnionitis (HCA) is a risk factor predisposing to leukemoid reaction (LR) and whether LR is associated with the preterm parturition syndrome and the systemic fetal inflammation response syndrome. A prospective histological study on placentas was performed in preterm infants (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.017
更新日期:2006-01-01 00:00:00
abstract::This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80103-7
更新日期:1976-09-01 00:00:00
abstract::The ontogeny and distribution of the epidermal growth factor (EGF) receptor and lipocortin-1, a major cellular substrate of the EGF receptor, were evaluated in a developmental series of fetal and neonatal human lungs (8 to 41 weeks' gestation and stillborn to 16 days' postnatal age). The peroxidase anti-peroxidase tec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90127-q
更新日期:1990-02-01 00:00:00
abstract::Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.017
更新日期:2011-12-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia chromosome (Ph1) by cytogenetic analysis. This acquired karyotypic abnormality is the product of a balanced translocation between the c-abl oncogene on chromosome 9 and the breakpoint cluster region (BCR) gene on chromosome 22. The ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90225-9
更新日期:1994-06-01 00:00:00
abstract::Several techniques for diagnosing adenocarcinoma of the lung are commonly available, but the frequency of their use and diagnostic sensitivity may vary. Twenty cases of primary lung adenocarcinoma obtained at surgery were studied by the following four routine techniques: light microscopy (LM) using hematoxylin-eosin (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80005-4
更新日期:1988-08-01 00:00:00
abstract::This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.012
更新日期:2017-01-01 00:00:00
abstract::The natural history of pediatric nonalcoholic steatohepatitis is still unknown; however, there are differences between adult and pediatric presentation. Apoptosis may play an important role in pathophysiologic pathways involved in liver damage and progression. Our aim was to detect early apoptosis markers, activated c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.04.022
更新日期:2008-12-01 00:00:00
abstract::Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90056-m
更新日期:1993-01-01 00:00:00
abstract::Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.01.012
更新日期:2006-06-01 00:00:00
abstract::Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (rang...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.09.007
更新日期:2020-12-01 00:00:00
abstract::Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereby triggering hematopoietic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.09.012
更新日期:2011-05-01 00:00:00
abstract::Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.10.014
更新日期:2009-05-01 00:00:00
abstract::Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histolo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.05.008
更新日期:2004-09-01 00:00:00
abstract::Grade Group (GG) 4 prostate cancer includes Gleason scores (GS) 3 + 5 = 8, 4 + 4 = 8, and 5 + 3 = 8. Some studies without pathology re-review of historical cohorts proposed that the presence of pattern 5 worsens prognosis compared to GS 4 + 4 = 8 cancer. We assessed how often historically graded GS 5 + 3 = 8 cancers r...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2019.11.002
更新日期:2020-03-01 00:00:00
abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90232-4
更新日期:1996-09-01 00:00:00
abstract::Clinicopathologic records and neuropathologic tissues of 109 patients who underwent necropsy after treatment with bone marrow transplantation (BMT) were examined. Underlying disorders included leukemia (70), aplastic anemia (25), solid tumors (7), lymphoma (5), Hodgkin's disease (1) and Wiskott-Aldrich syndrome (1). T...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90010-6
更新日期:1990-06-01 00:00:00
abstract::Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.010
更新日期:2004-10-01 00:00:00
abstract::Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.010
更新日期:2015-03-01 00:00:00