High-grade squamous cell carcinoma arising in a tibial adamantinoma.

abstract：:The case of a patient in whom idiopathic thrombocytopenic purpura (ITP) was associated with diffuse splenic histiocytosis is described; the patient's subsequent sphingomyelinase level was at the lower limits of the normal range. The patient's splenic lecithin:sphingomyelin ratio was not significantly different from th...

journal_title：Human pathology

authors： Hom BL,Belles Q,Oishi N

更新日期：1985-11-01 00:00:00

abstract：:The cell of origin of parafollicular (monocytoid) B cell lymphoma (PBCL), splenic marginal zone lymphoma (SMZL), and hairy cell leukemia (HCL) is controversial. To better understand the relationship between these low-grade B-cell neoplasms, we analyzed the nucleotide sequences of the rearranged immunoglobulin heavy (I...

journal_title：Human pathology

authors： Miranda RN,Cousar JB,Hammer RD,Collins RD,Vnencak-Jones CL

更新日期：1999-03-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...

journal_title：Human pathology

authors： Kumazaki K,Nakayama M,Suehara N,Wada Y

更新日期：2002-11-01 00:00:00

abstract：:Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...

journal_title：Human pathology

authors： Zhang M,Adeniran AJ,Vikram R,Tamboli P,Pettaway C,Bondaruk J,Liu J,Baggerly K,Czerniak B

更新日期：2018-02-01 00:00:00

abstract：:A distinctive variant of basal cell adenoma called membranous basal cell adenoma is well recognized in salivary glands. It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor. We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma. In ad...

journal_title：Human pathology

authors： Kazakov DV,Benkova K,Michal M,Vanecek T,Kacerovska D,Skalova A

更新日期：2009-10-01 00:00:00

abstract：:A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...

journal_title：Human pathology

authors： Nezelof C,Seemayer TA,Bridge JA

更新日期：2010-03-01 00:00:00

abstract：:To assess the proliferative activity of renal cell carcinoma (RCC-A) in patients with acquired cystic disease of the kidney (ACDK) after long-term hemodialysis, we analyzed cell cycle, DNA ploidy, and S-phase fraction by flow cytometry (FCM) and proliferating cell nuclear antigen (PCNA) labeling index by immunohistoch...

journal_title：Human pathology

authors： Ikeda R,Tanaka T,Moriyama MT,Kawamura K,Miyazawa K,Suzuki K

更新日期：2002-02-01 00:00:00

abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...

journal_title：Human pathology

authors： Turner JR,Odze RD,Crum CP,Resnick MB

更新日期：1997-06-01 00:00:00

abstract：:Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...

journal_title：Human pathology

authors： Veinot JP,Gattinger DA,Fliss H

更新日期：1997-04-01 00:00:00

abstract：:The concurrent presence of JAK2 V617F, monocytosis, and bone marrow fibrosis can be observed in both chronic myelomonocytic leukemia (CMML) and primary myelofibrosis (PMF). It can be challenging to distinguish CMML with JAK2 mutation and fibrosis from other myeloid neoplasms, particularly PMF. To identify key features...

journal_title：Human pathology

authors： Hu Z,Ramos CEB,Medeiros LJ,Zhao C,Yin CC,Li S,Hu S,Wang W,Thakral B,Xu J,Verstovsek S,Lin P

更新日期：2019-03-01 00:00:00

abstract：:This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological e...

journal_title：Human pathology

authors： Kanno H,Onodera H,Endo M,Maeda F,Chida S,Akasaka T,Sawai T

更新日期：2005-02-01 00:00:00

abstract：:This report concerns a young woman who, after taking a contraceptive preparation orally for three years, developed the Budd-Chiari syndrome as the result of a widespread chronic obliterative process involving the intrahepatic efferent venous system. Her prolonged course, which failed to respond to an end-to-side porta...

journal_title：Human pathology

authors： Alpert LI

更新日期：1976-11-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...

journal_title：Human pathology

authors： Lee RG

更新日期：1989-06-01 00:00:00

abstract：:δ-Like ligand 4 (DLL4), a ligand for the Notch family of receptors, forecasts the prognosis of several human malignancies. However, the expression and role of DLL4 in breast cancer remain largely unknown. In the present study, we first evaluated whether the overexpression of DLL4 could be used as an indicator of axill...

journal_title：Human pathology

authors： Xiao M,Yang S,Ning X,Huang Y

更新日期：2014-11-01 00:00:00

abstract：:Collapsing glomerulopathy (CG), an aggressive variant of focal segmental glomerular sclerosis, is a renal disease with severe proteinuria and rapidly progressive renal failure. The pathogenesis of CG is unknown. It strongly resembles human immunodeficiency virus (HIV)-associated nephropathy, but the patients are HIV n...

journal_title：Human pathology

authors： Nadasdy T,Allen C,Zand MS

更新日期：2002-04-01 00:00:00

abstract：:Enteroendocrine cell dysgenesis was observed in 3 patients with intestinal failure of unknown cause. Enteroendocrine cell dysgenesis is a congenitally acquired life-threatening malabsorptive condition with a unique clinical phenotype paired with a histologically identifiable disease pattern. Two cases were first prese...

journal_title：Human pathology

authors： Cortina G,Smart CN,Farmer DG,Bhuta S,Treem WR,Hill ID,Martín MG

更新日期：2007-04-01 00:00:00

abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...

journal_title：Human pathology

authors： Huo L,Sugimura J,Tretiakova MS,Patton KT,Gupta R,Popov B,Laskin WB,Yeldandi A,Teh BT,Yang XJ

更新日期：2005-03-01 00:00:00

abstract：:Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase (IDH) genes represent a novel class of point mutations in acute myeloid leukemia. These mutations prevent oxidative decarboxylation of isocitrate to α-ketoglutarate and confer novel enzymatic activity, facilitating t...

journal_title：Human pathology

authors： Rakheja D,Konoplev S,Medeiros LJ,Chen W

更新日期：2012-10-01 00:00:00

abstract：:Primary small bowel adenocarcinoma is rare. Although generally similar to colonic adenocarcinoma, some small bowel adenocarcinomas exhibit unique morphologic features, particularly those arising in association with Crohn disease. In this study, 15 sporadic small bowel adenocarcinomas and 11 Crohn enteritis-associated ...

journal_title：Human pathology

authors： Whitcomb E,Liu X,Xiao SY

更新日期：2014-02-01 00:00:00

abstract：:Clinicopathologic records and neuropathologic tissues of 109 patients who underwent necropsy after treatment with bone marrow transplantation (BMT) were examined. Underlying disorders included leukemia (70), aplastic anemia (25), solid tumors (7), lymphoma (5), Hodgkin's disease (1) and Wiskott-Aldrich syndrome (1). T...

journal_title：Human pathology

authors： Mohrmann RL,Mah V,Vinters HV

更新日期：1990-06-01 00:00:00

abstract：:Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...

journal_title：Human pathology

authors： Ji J,Zheng PS

更新日期：2010-10-01 00:00:00

abstract：:Intrasinusoidal infiltration of bone marrow (BM) may accompany several malignant lymphoproliferative disorders. In small B-cell lymphomas, this pattern is considered specific for splenic marginal zone lymphoma (SMZL) when exclusive or prominent, although it may occur in other subtypes of non-Hodgkin's lymphomas (NHLs)...

journal_title：Human pathology

authors： Schenka AA,Gascoyne RD,Duchayne E,Delsol G,Brousset P

更新日期：2003-08-01 00:00:00

abstract：:Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen dep...

journal_title：Human pathology

authors： Katzenstein AL

更新日期：1985-10-01 00:00:00

abstract：:Except for post-transfusion hepatitis (PTH), the transmission of disease by blood transfusion appears to be very limited. There are only a few case reports documenting the transmission of malaria and other parasitic diseases, syphilis, or bacterial infections. The ability to eradicate PTH will depend on the developmen...

journal_title：Human pathology

authors： Kahn RA

更新日期：1983-03-01 00:00:00

abstract：:Digitization of histologic slides is associated with many advantages, and its use in routine diagnosis holds great promise. Nevertheless, few articles evaluate virtual microscopy in routine settings. This study is an evaluation of the validity and diagnostic performance of virtual microscopy in routine histologic diag...

journal_title：Human pathology

authors： Nielsen PS,Lindebjerg J,Rasmussen J,Starklint H,Waldstrøm M,Nielsen B

更新日期：2010-12-01 00:00:00

abstract：:Thirty-nine mammographically detected, (M-detected) small invasive carcinomas of the breast (< or = 5 mm) were compared with 78 consecutive clinical cancers (> or = 10 mm) for a variety of morphological and biological markers of prognostic importance. There were more tubular carcinomas in the M-detected group (12.8% v...

journal_title：Human pathology

authors： Moezzi M,Melamed J,Vamvakas E,Inghirami G,Mitnick J,Quish A,Bose S,Zelman G,Roses D,Harris M,Feiner H

更新日期：1996-09-01 00:00:00

abstract：:A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...

journal_title：Human pathology

authors： Zerbini C,Weinberg DS,Perez-Atayde AR

更新日期：1992-12-01 00:00:00

abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...

journal_title：Human pathology

authors： Shahi M,Bloechl SJ,Vogel RI,Shrestha R,Krigman HR,Evasovich M,Burmeister LA,Amin K

更新日期：2019-11-01 00:00:00

abstract：:The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...

journal_title：Human pathology

authors： Yeh MM,Belt P,Brunt EM,Kowdley KV,Wilson LA,Ferrell L,Nonalcoholic Steatohepatitis Clinical Research Network.

更新日期：2016-06-01 00:00:00

abstract：:Cribriform and/or papillary prostatic lesions observed on limited tissue, such as needle biopsy, can pose diagnostic dilemmas. One such area of difficulty is the distinction between papillary and/or cribriform prostatic high-grade prostatic intraepithelial neoplasia (HG-PIN) and ductal adenocarcinoma. Over 48 months, ...

journal_title：Human pathology

authors： Rioux-Leclercq N,Leray E,Patard JJ,Lobel B,Guillé F,Jouan F,Bellaud P,Epstein JI

更新日期：2005-05-01 00:00:00