Abstract：
:Three ovarian thecomas were studied by ultrastructural and immunohistochemical techniques. In each tumor, a small number of tumor cells stained for estradiol. Vacuolated as well as plump non-vacuolated tumor cells were positive, but spindle-shaped cells were negative. Ultrastructural examination showed two principle cell types. Type I cells were immature mesenchymal cells that differed from typical steroid-secreting cells because only a minority had conspicuous smooth endoplasmic reticulum, although mitochondria often had tubular cristae. Type II cells were distinguished by abundant intermediate (10-nm) microfilaments and round mitochondria with incomplete cristae and empty centers. Focal smooth muscle differentiation was present in each tumor. Adherens-type intercellular junctions, including desmosomes in one case, and degenerate cells with markedly vesiculated cytoplasmic membrane systems were also present. Lipid was not abundant, but it was more conspicuous in degenerate cells and in type II cells. Thecoma cells thus closely resemble both ovarian stromal cells and theca interna cells, which are known to be capable of steroidogenesis. The localization of estradiol in a minority of tumor cells in each thecoma suggests that thecoma cells, too, are capable of steroid synthesis and supports the popular concept that hyperestrogenism in patients with thecomas may be the result of estradiol secretion by these tumors.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Gaffney EF,Majmudar B,Hewan-Lowe Kdoi
10.1016/s0046-8177(84)80056-8subject
Has Abstractpub_date
1984-02-01 00:00:00pages
153-60issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(84)80056-8journal_volume
15pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:To better represent the Gleason score of radical prostatectomy, the International Society of Urologic Pathologists Consensus Committee recommends assigning individual Gleason scores to prostate cancer cores submitted in separate containers and/or multiple cores in the same container with site identifiers. However, sce...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.07.020
更新日期：2009-04-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:Pleomorphic adenoma (PA) is the most common benign tumor of salivary glands. Carcinomas in pleomorphic adenomas (CPAs) may arise by malignant transformation of the epithelial components of PAs. Occasionally, transitional zones containing cells with histological features intermediate between those of the benign PA and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90449-9
更新日期：1996-08-01 00:00:00
abstract：:Implementation of Grade Groups (GrGrs) has been widely accepted for reporting prostate cancer grade since the 2014 International Society of Urological Pathology consensus meeting. Despite their undisputed value for risk stratification, some GrGr are, a priori, quite heterogeneous in that they contain multiple Gleason ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.03.001
更新日期：2020-05-01 00:00:00
abstract：:Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.12.003
更新日期：2010-06-01 00:00:00
abstract：:This article briefly describes the origin of one of the more common (food-related) pathologic terms--"bread and butter pericarditis." The eminent French physician, Laennec, the inventor of the stethoscope amongst several other important medical contributions, can be credited for having coined the term that is still in...
journal_title：Human pathology
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.humpath.2003.08.029
更新日期：2004-02-01 00:00:00
abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90114-4
更新日期：1999-04-01 00:00:00
abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.005
更新日期：2015-01-01 00:00:00
abstract：:A young male with Buerger's disease who had previously required a left leg amputation died in renal failure and sepsis. Postmortem examination revealed an obliterative lesion of the celiac artery, which resulted in hepatic, splenic, and pancreatic infarctions. Celiac artery involvement represents an unusual manifestat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80080-5
更新日期：1979-01-01 00:00:00
abstract：:In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.012
更新日期：2018-10-01 00:00:00
abstract：:The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for carcinomas of the large intestine are reported herein. ...
journal_title：Human pathology
pub_type： 指南,杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:In two patients with malignant germ cell tumors angiosarcoma developed through two apparently different mechanisms. In one case the angiosarcoma probably developed as a complication of therapeutic radiation, since radiation changes were demonstrated in tissue adjacent to the neoplasm and since the angiosarcoma was not...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80013-7
更新日期：1985-03-01 00:00:00
abstract：:Lymphocytic colitis, previously termed "microscopic colitis", is a clinicopathologic syndrome of watery diarrhea, grossly normal colonoscopy, and mucosal inflammatory changes. Since lymphocytic colitis is a new, incompletely characterized entity, a histopathologic study was performed to compare lymphocytic colitis (n ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90198-6
更新日期：1989-01-01 00:00:00
abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80251-7
更新日期：1982-12-01 00:00:00
abstract：:Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.11.013
更新日期：2007-05-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90287-2
更新日期：1997-01-01 00:00:00
abstract：:Enteroendocrine cell dysgenesis was observed in 3 patients with intestinal failure of unknown cause. Enteroendocrine cell dysgenesis is a congenitally acquired life-threatening malabsorptive condition with a unique clinical phenotype paired with a histologically identifiable disease pattern. Two cases were first prese...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.10.014
更新日期：2007-04-01 00:00:00
abstract：:Snail1 and ZEB1 are transcriptional repressors that drive tumor initiation and metastasis in animal models. Snail1 and ZEB1 are frequently coexpressed in tumor cell lines, suggesting that these factors may cooperate to promote tumor progression. However, coexpression of these transcriptional repressors in primary huma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.004
更新日期：2011-08-01 00:00:00
abstract：:In this study, we assessed the changes and prognostic relevance of syndecan-1 (SDC1) tissue and serum levels in bladder cancer (BC). SDC1 levels were analyzed in 213 samples (119 paraffin-embedded and 79 serum samples of BC patients and 15 controls) using immunohistochemistry and enzyme-linked immunosorbent assay. Res...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.036
更新日期：2014-04-01 00:00:00
abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.03.007
更新日期：2017-06-01 00:00:00
abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.030
更新日期：2007-11-01 00:00:00
abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2015.06.013
更新日期：2015-09-01 00:00:00
abstract：:Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7894
更新日期：2000-06-01 00:00:00
abstract：:Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.07.041
更新日期：2017-03-01 00:00:00
abstract：:Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conven...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80182-8
更新日期：1983-11-01 00:00:00
abstract：:Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are di...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(77)80025-7
更新日期：1977-05-01 00:00:00
abstract：:Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.03.028
更新日期：2012-12-01 00:00:00
abstract：:Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.08.006
更新日期：2018-02-01 00:00:00
abstract：:Cell adhesion molecule expression has been linked to disease outcome in prostatic adenocarcinomas (PACs). We evaluated the coordinated expression of catenin-related proteins, E-cadherin, N-cadherin, and CD44s in PACs. Archival sections from 112 PACs were immunostained by an automated method (Ventana Medical Systems, T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.26463
更新日期：2001-08-01 00:00:00
abstract：:Women with breast cancer have an increased risk of developing primary ovarian tumors. Because a differential diagnosis between primary and metastatic tumors may be difficult in poorly differentiated ovarian neoplasms, breast carcinoma markers may be helpful in establishing the primary site of origin. Gross cystic dise...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90084-3
更新日期：1991-04-01 00:00:00
