Abstract：
:Cardiac myxoma is the most common primary tumor of the heart. A detailed evaluation of cell types in 41 cardiac myxomas by light microscopy and in 30 cases by immunohistochemistry was made. Reactivity to the various antisera were observed in the surface lining cells, the stromal myxoma cells and the cells in the perivascular location. Factor VIII-related antigen (FVIIIR-Ag) and Ulex europaeus agglutinin (UEA-1), both endothelial markers, were positive in 23 cases each. UEA-1 was found to be a more sensitive marker than factor VIII. Desmin and myoglobin were positive in 16 and 24 cases, respectively. Reactivity for cytokeratin was noted in ten cases, one of which showed glandular differentiation. Vimentin and S-100 positivity was obtained in 16 and 14 cases respectively. Thus, cardiac myxoma appears to arise from multipotent cells which have the potential to differentiate along several mesenchymal cells or epithelial cells and may also concurrently exhibit reactivity for both mesenchymal and epithelial markers.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Deshpande A,Venugopal P,Kumar AS,Chopra Pdoi
10.1016/s0046-8177(96)90283-xsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
1056-9issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(96)90283-Xjournal_volume
27pub_type
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