Abstract:
:In a large-scale analysis of gene expression in pancreatic cancer, we isolated the homologue of the mouse Rab20. The mouse protein was previously identified during a search for novel Rab proteins, a family of small GTP-binding proteins involved in the regulation of intracellular vesicular transport. The Rab20 protein has no close relationship to any member of the Rab protein subfamily. In contrast to other members, it contains an insertion of 40 amino acids of unknown function and an inversion of 3 amino acids at the position corresponding to codon 61 in p21ras proteins. Using immunofluorescence and immunoelectron microscopy, we localized the Rab20 protein in the vicinity of the Golgi apparatus. Rab20 expression was detected by Western blot analysis in 11 of 11 pancreatic tumor cell lines and 7 of 8 primary pancreatic carcinomas. Absent or very faint expression was observed in normal pancreas cell extracts. Immunohistochemical analysis of Rab20 in tissues showed low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas. Rab20 was also detected in preneoplastic pancreatic intraductal neoplasia lesions, suggesting that its up-regulation may be an early event in pancreatic carcinogenesis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Amillet JM,Ferbus D,Real FX,Antony C,Muleris M,Gress TM,Goubin Gdoi
10.1016/j.humpath.2005.10.017subject
Has Abstractpub_date
2006-03-01 00:00:00pages
256-63issue
3eissn
0046-8177issn
1532-8392pii
S0046-8177(05)00635-0journal_volume
37pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80237-7
更新日期:1981-01-01 00:00:00
abstract::The aim of the current study was to test whether the grade group assessed in the index tumor nodule predicts biochemical recurrence after surgery. The study cohort series included 144 consecutive patients treated by laparoscopic radical prostatectomy. The following parameters were evaluated in each case: type of radic...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.08.012
更新日期:2019-11-01 00:00:00
abstract::The surgical pathologist is often called upon to make a rapid decision about the malignant potential of a soft tissue tumor. These tumors have specific stromas that support growth and endow the tumor with unique qualities, as well as being manifestations of the phenotypic expression of tumor cells. Collagen, the major...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80080-9
更新日期:1981-09-01 00:00:00
abstract::Implementation of Grade Groups (GrGrs) has been widely accepted for reporting prostate cancer grade since the 2014 International Society of Urological Pathology consensus meeting. Despite their undisputed value for risk stratification, some GrGr are, a priori, quite heterogeneous in that they contain multiple Gleason ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.03.001
更新日期:2020-05-01 00:00:00
abstract::Although T-lineage large granular lymphocyte (LGL) leukemia has been described for over 20 years, many patients with this neoplasm go unrecognized. Chief among the difficulties in diagnosing this entity is that the morphologic features are nonspecific and that it is difficult to distinguish it from reactive processes....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.19298
更新日期:2000-10-01 00:00:00
abstract::The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80052-7
更新日期:1987-08-01 00:00:00
abstract::Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histolo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.05.008
更新日期:2004-09-01 00:00:00
abstract::The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90005-5
更新日期:1995-08-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major efforts is being made to identify molecular markers capable to differentiate oral potentially malignant lesions (OPMLs) with indolent course from lesions with aggressive behavior. We undertook a study to evaluate if gain of the human telomer...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.013
更新日期:2015-09-01 00:00:00
abstract::Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90231-3
更新日期:1998-02-01 00:00:00
abstract::Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal adhesion sites, which are specific areas on the cell membrane where cells attach to extracellular matrix proteins. Focal adhesion kinase interacts with multiple signaling and adaptor molecules and effects several signaling pathways. O...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.024
更新日期:2006-01-01 00:00:00
abstract::Fetal vessels in the placentas of 11 of 15 infants with cerebral palsy contained thrombi. An alternate basis for the injury was identified in the four placentas without thrombi. Autopsy findings in one infant who died at age 1 month confirmed the presence of cerebral thrombi and infarcts. It is concluded that thrombot...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90114-3
更新日期:1997-02-01 00:00:00
abstract::Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.01.003
更新日期:2018-04-01 00:00:00
abstract::CD44 is an integral membrane glycoprotein that is a principal receptor for hyaluronan and plays a role in cell-extracellular matrix interactions. Recent studies of melanomas in mouse models have suggested that increased CD44 expression by these tumors may relate to metastatic potential. Immunohistochemical expression ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90339-1
更新日期:1996-12-01 00:00:00
abstract::Wild type p53 plays a crucial role in maintaining genomic stability in both normal and tumor cells in vitro. When DNA damage occurs, p53 acts as a cell cycle checkpoint and induces a cellular response that aims at restoring genomic integrity. p53 may either allow the repair of damaged DNA by inducing a transient G1 ar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90292-9
更新日期:1995-12-01 00:00:00
abstract::Esophageal cancer is one of the most fatal cancers worldwide and is characterized by great variation in rates among different populations. Linxian, a county in Henan Province, located in north-central China, has one of the highest rates of esophageal squamous cell carcinoma in the world. Most squamous cell carcinomas ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90260-x
更新日期:1998-11-01 00:00:00
abstract::Twenty-one childhood rhabdomyosarcomas were divided into three groups on the basis of cytologic composition. The tumors in group P consisted entirely of primitive mesenchymal cells, whereas those in groups M and W were characterized by the additional presence of numerous round rhabdomyoblasts and strap cells, respecti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80256-2
更新日期:1985-08-01 00:00:00
abstract::Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80205-1
更新日期:2000-01-01 00:00:00
abstract::Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.09.011
更新日期:2015-02-01 00:00:00
abstract::The molecular pathology of 20 lymphomas, which presented as testicular masses in patients with no evidence of previous lymphoma, was analyzed. These lymphomas occurred in men with a median age of 69 years (range, 37 to 87 years). Nine of the 14 patients with follow-up died of lymphoma (median survival, 12 months). All...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90250-7
更新日期:1998-11-01 00:00:00
abstract::Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80100-7
更新日期:1977-11-01 00:00:00
abstract::Thrombosis of large fetal vessels in the placenta leads to regions of downstream avascular villi (AV). Avascular villi have been associated with adverse outcomes in anecdotal reports, but no controlled study of their significance has been done. We prospectively gathered cases of extensive AV (n = 29) occurring over a ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90118-3
更新日期:1995-01-01 00:00:00
abstract::The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90125-1
更新日期:1989-03-01 00:00:00
abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2006.10.006
更新日期:2007-04-01 00:00:00
abstract::Germline BRCA mutations account for a significant proportion of genetic/familial risk of breast and ovarian cancer (GBOC) susceptibility, but a broader spectrum of GBOC susceptibility genes has emerged in recent years. Genotype-to-phenotype correlations are known for some established forms of GBOC; however, whether su...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.06.018
更新日期:2017-12-01 00:00:00
abstract::The case of a patient in whom idiopathic thrombocytopenic purpura (ITP) was associated with diffuse splenic histiocytosis is described; the patient's subsequent sphingomyelinase level was at the lower limits of the normal range. The patient's splenic lecithin:sphingomyelin ratio was not significantly different from th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80192-1
更新日期:1985-11-01 00:00:00
abstract::Neoglycoproteins are readily available conjugates of a histochemically inert carrier protein and histochemically crucial carbohydrate moieties which are covalently attached to the carrier protein by chemical synthesis. Biotinylation renders these conjugates detectable in formalin-fixed, paraffin-embedded tissue sectio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90045-2
更新日期:1989-04-01 00:00:00
abstract::Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lym...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.08.009
更新日期:2007-02-01 00:00:00
abstract::In this study, we assessed the changes and prognostic relevance of syndecan-1 (SDC1) tissue and serum levels in bladder cancer (BC). SDC1 levels were analyzed in 213 samples (119 paraffin-embedded and 79 serum samples of BC patients and 15 controls) using immunohistochemistry and enzyme-linked immunosorbent assay. Res...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.036
更新日期:2014-04-01 00:00:00
abstract::Although all carcinoid tumors are considered potentially malignant, the biologic behaviors of appendiceal and ileal carcinoids are distinctly different. Appendiceal carcinoids often behave in a benign fashion, whereas ileal carcinoids pursue an aggressive course with frequent metastasis. Whether differences in DNA plo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90052-5
更新日期:1992-12-01 00:00:00