Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma.

Abstract:

:The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation. The data suggested that IGF2 and IGFBP2 gene expression could be regarded as a marker for assessment of the degree of differentiation in hepatoblastoma.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Akmal SN,Yun K,MacLay J,Higami Y,Ikeda T

doi

10.1016/0046-8177(95)90005-5

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

846-51

issue

8

eissn

0046-8177

issn

1532-8392

pii

0046-8177(95)90005-5

journal_volume

26

pub_type

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