Abstract:
:The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation. The data suggested that IGF2 and IGFBP2 gene expression could be regarded as a marker for assessment of the degree of differentiation in hepatoblastoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Akmal SN,Yun K,MacLay J,Higami Y,Ikeda Tdoi
10.1016/0046-8177(95)90005-5subject
Has Abstractpub_date
1995-08-01 00:00:00pages
846-51issue
8eissn
0046-8177issn
1532-8392pii
0046-8177(95)90005-5journal_volume
26pub_type
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