Clinicopathologic findings in patients with infantile hemiparesis and epilepsy.

Abstract:

:Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopathologic features in a surgical series of 21 patients with infantile hemiparesis. The study group was comprised of 21 patients, 13 females and 8 males, ranging in age from 5 to 41 years (mean, 20 years) at the time of surgery. Hemiparesis involved the right side in 16 patients and the left side in 5 patients. Imaging studies identified porencephaly in 8 patients (38%), encephalomalacia in 5 patients (24%), focal cerebral atrophy in 9 patients (43%), ventricular dilatation in 6 patients (29%), and white matter hyperintensities in 4 patients (19%). Concomitant neurologic diseases included medically intractable epilepsy in all 21 patients and visual field defects in 11 patients (52%). Significant perinatal history included prematurity in 7 patients (33%) and cesarean section, forceps delivery, placental abruption, fetal distress, and prolonged rupture of membranes each in 1 patient (5%). The remainder of the patients had an uncomplicated perinatal course (43%). Twelve patients underwent functional hemispherectomy (57%), 8 patients underwent lobectomy (38%) and 1 patient underwent "cyst" resection (5%). Histological evaluation demonstrated lesional (corresponding to radiographic findings) tissue in 15 of the 21 cases (71%). Infarction, malformations due to abnormalities of cortical development (cortical dysplasia) and gliosis with microcalcifications were each found in 6 patients (29%). Infarction and a geographically distinct area of cortical dysplasia were found to coexist in 1 case. Histopathologic findings in the 6 cases in which excised tissue was considered nonlesional included gliosis in all 6 of the cases, hippocampal sclerosis in 2 cases (10%), and neuronal heterotopia in 2 cases (10%). An osteoma was identified in 1 patient. The most common pathological findings observed in our series were infarction and cortical dysplasia, although radiographically, infarct-related changes were the most evident. Hippocampal sclerosis was encountered in 2 patients, suggesting that a subset of cortical dysplasias and hippocampal sclerosis may be caused by an in utero ischemic event.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Prayson RA,Hannahoe BM

doi

10.1016/j.humpath.2004.02.013

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

734-8

issue

6

eissn

0046-8177

issn

1532-8392

pii

S0046817704001418

journal_volume

35

pub_type

杂志文章
  • Bone marrow biopsies in patients with the acquired immunodeficiency syndrome.

    abstract::Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marr...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(84)80248-8

    authors: Osborne BM,Guarda LA,Butler JJ

    更新日期:1984-11-01 00:00:00

  • Diagnosis of chronic endometritis in biopsies with stromal breakdown.

    abstract::Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes ("disordered proliferative" and "anovulatory" patterns), and stromal breakdown. We reviewe...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2006.09.002

    authors: Gilmore H,Fleischhacker D,Hecht JL

    更新日期:2007-04-01 00:00:00

  • Structured electronic template for histopathology reports on colorectal carcinomas: a joint project by the Cancer Registry of Norway and the Norwegian Society for Pathology.

    abstract::Both individual patient treatment and cancer registries depend on adequate histopathology reports. To ensure the quality of these reports, professional organizations have published guidelines on minimum data sets for various cancer types. Norway has a population of 4.6 million, and all individuals have a unique identi...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2007.06.019

    authors: Bjugn R,Casati B,Norstein J

    更新日期:2008-03-01 00:00:00

  • Chondromyxoid fibroma of bone: thirty-six cases with clinicopathologic correlation.

    abstract::A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms. In this series, CMFs were found in patients of all age groups, with no predominance between sexes. Long bone tumors wer...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(89)90267-0

    authors: Zillmer DA,Dorfman HD

    更新日期:1989-10-01 00:00:00

  • Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype.

    abstract::Cytoplasmic mislocalization of p27 (CDKN1B/KIP1) is caused by activated AKT1 and has been associated with poor prognosis in various cancers. CIMP in colorectal cancer is characterized by extensive promoter methylation and is associated with MSI-MSI-H and BRAF mutations. We have recently shown a positive correlation be...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2006.09.014

    authors: Ogino S,Kawasaki T,Ogawa A,Kirkner GJ,Loda M,Fuchs CS

    更新日期:2007-04-01 00:00:00

  • Stage IVS neuroblastoma: a clinical, histological, and biological analysis of 45 cases.

    abstract::This study reports clinicopathologic and biological analysis of 45 stage IVS neuroblastomas (IVS-NBs). All IVS-NB cases had small or undetectable primary tumors associated with disease involving the liver, skin, or bone marrow. Their ages at diagnosis ranged from 1 day to 12 months, with a median age of 4 months. The ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(96)90304-4

    authors: Hachitanda Y,Hata J

    更新日期:1996-11-01 00:00:00

  • Giant cell carcinoma of the lung. A light and electron microscopic study.

    abstract::Three cases of giant cell carcinoma of lung and six other lung carcinomas with large atypical cell formation were studied by both light and electron microscopy. The giant cell carcinomas showed unique light and electron microscopic features, whereas large atypical cells from other lung carcinomas usually retained some...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(76)80003-2

    authors: Wang NS,Seemayer TA,Ahmed MN,Knaack J

    更新日期:1976-01-01 00:00:00

  • Cyclin D1 and MIB-1 immunohistochemistry in pilocytic astrocytomas: a study of 48 cases.

    abstract::Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(98)90023-5

    authors: Machen SK,Prayson RA

    更新日期:1998-12-01 00:00:00

  • Expression of classic cadherins type I in urothelial neoplastic progression.

    abstract::Loss or reduced expression of E-cadherin has been shown to be associated with poor survival in patients with bladder cancer. In numerous cases, loss of E-cadherin expression in bladder tumors has been accompanied by continued association of catenins with the membrane, suggestive of the expression of an alternative cad...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2001.21140

    authors: Rieger-Christ KM,Cain JW,Braasch JW,Dugan JM,Silverman ML,Bouyounes B,Libertino JA,Summerhayes IC

    更新日期:2001-01-01 00:00:00

  • WITHDRAWN: Gastric foveolar metaplasia in the duodenum-the contravener may have escaped-Reply.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2011.01.032

    authors: Genta RM

    更新日期:2011-04-17 00:00:00

  • Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.

    abstract::The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2007.01.022

    authors: Conde E,Suarez-Gauthier A,García-García E,Lopez-Rios F,Lopez-Encuentra A,García-Lujan R,Morente M,Sanchez-Verde L,Sanchez-Cespedes M

    更新日期:2007-09-01 00:00:00

  • Silicone lymphadenopathy in a long distance runner: complication of a silastic prosthesis.

    abstract::A 33-year-old male runner, who had undergone a Swanson silastic prosthetic implant for degenerative joint disease of the first metatarsal head and proximal phalanx of the right great toe, presented with unilateral inguinal lymphadenopathy. Biopsy revealed confluent, non-caseating granulomas containing silastic materia...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(88)80158-8

    authors: Rogers LA,Longtine JA,Garnick MB,Pinkus GS

    更新日期:1988-10-01 00:00:00

  • Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma.

    abstract::A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(97)90261-6

    authors: Moysset I,Lloreta J,Miguel A,Vadell C,Ribalta T,Estrach T,Serrano S

    更新日期:1997-10-01 00:00:00

  • Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation.

    abstract::Invasive mammary carcinoma with neuroendocrine differentiation has been controversial in terms of its definition and clinical outcome. In 2003, the World Health Organization histologic classification of tumors designated this entity as neuroendocrine carcinoma of the breast and defined mammary neuroendocrine carcinoma...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2010.11.014

    authors: Tian Z,Wei B,Tang F,Wei W,Gilcrease MZ,Huo L,Albarracin CT,Resetkova E,Middleton L,Sahin A,Xing Y,Hunt KK,Chen J,Bu H,Rashid A,Abraham SC,Wu Y

    更新日期:2011-08-01 00:00:00

  • Androgen receptor, androgen-producing enzymes and their transcription factors in extramammary Paget disease.

    abstract::Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen productio...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2015.07.007

    authors: Azmahani A,Nakamura Y,Ozawa Y,McNamara KM,Fujimura T,Haga T,Hashimoto A,Aiba S,Sasano H

    更新日期:2015-11-01 00:00:00

  • Polymorphic fibro-osseous lesions of bone: an almost site-specific diagnostic problem of the proximal femur.

    abstract::Atypical fibro-osseous lesions, usually in the proximal femur, are a common consultative diagnostic problem. This is due to the fact that they contain a variety of patterns individually reminiscent of fibrous dysplasia, fibroxanthoma (non-ossifying fibroma), myxofibroma, lipoma, cyst, bone infarct, Paget's disease, an...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(93)90162-a

    authors: Ragsdale BD

    更新日期:1993-05-01 00:00:00

  • Massive chronic intervillositis associated with recurrent abortions.

    abstract::Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chr...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(95)90201-5

    authors: Doss BJ,Greene MF,Hill J,Heffner LJ,Bieber FR,Genest DR

    更新日期:1995-11-01 00:00:00

  • Lymph node metastasis in early gastric cancer: evaluation of a novel method for measuring submucosal invasion and development of a nodal predicting index.

    abstract::After endoscopic resection of early gastric cancer (EGC), it is imperative to accurately determine whether follow-up surgery is indicated, since this technique is used as a first line of treatment. Herein, we developed a scoring system to indicate the risk of lymph node metastasis in submucosal EGC (smEGC), and presen...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2013.07.037

    authors: Kim JY,Kim WG,Jeon TY,Kim GH,Jeong EH,Kim DH,Park DY,Lauwers GY

    更新日期:2013-12-01 00:00:00

  • Pityriasis lichenoides: a clonal T-cell lymphoproliferative disorder.

    abstract::Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2002.125381

    authors: Magro C,Crowson AN,Kovatich A,Burns F

    更新日期:2002-08-01 00:00:00

  • Undifferentiated (embryonal) sarcoma of the liver: ultrastructural and immunohistochemical similarities with malignant fibrous histiocytoma.

    abstract::Two undifferentiated (embryonal) sarcomas of liver were studied ultrastructurally and immunohistochemically. Electron microscopic examination of the pleomorphic tumor cells revealed fibroblastic and histiocytic characteristics. There were no specific findings to support rhabdomyoblastic, leiomyoblastic, or epithelial ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(85)80154-4

    authors: Keating S,Taylor GP

    更新日期:1985-07-01 00:00:00

  • Bcl-2 and Bcl-X expression in gangliogliomas.

    abstract::Bcl-2 and bcl-xL are proteins known to inhibit cell death (apoptosis). Expression of these proteins in gangliogliomas has not been extensively examined. This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas. Twenty-nine gangliogliomas in 17 males and 12 fe...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(99)90097-7

    authors: Prayson RA

    更新日期:1999-06-01 00:00:00

  • Epithelial-lined (true) cyst of the adrenal gland: a case report.

    abstract::A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(89)90017-8

    authors: Medeiros LJ,Weiss LM,Vickery AL Jr

    更新日期:1989-05-01 00:00:00

  • Amplicons in breast cancers analyzed by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.

    abstract::Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in breast cancers. An archive of 322 formalin-fixed and paraffin-embedded ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2018.10.017

    authors: Ooi A,Inokuchi M,Horike SI,Kawashima H,Ishikawa S,Ikeda H,Nakamura R,Oyama T,Dobashi Y

    更新日期:2019-03-01 00:00:00

  • Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma.

    abstract::Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that has morphologic features similar to secretory carcinoma of the breast and that also harbors the same ETV6 translocation. Diffuse mammaglobin and S-100 immunoreactivity are used to differentiate MASC from its morphologic mimic...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2013.06.010

    authors: Patel KR,Solomon IH,El-Mofty SK,Lewis JS Jr,Chernock RD

    更新日期:2013-11-01 00:00:00

  • Comparison of estrogen receptor, progesterone receptor and HER2 results in concurrent ipsilateral samples with invasive breast carcinoma: a retrospective study of 246 biopsies from 119 patients.

    abstract::There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2017.04.016

    authors: Singh K,Wang Y,Marketkar S,Kalife ET,Steinhoff MM

    更新日期:2017-07-01 00:00:00

  • The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast.

    abstract::Multifocal/multicentric breast cancers are common. However, investigations of biomarkers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 in individual tumor foci of such cancers are rare. This study was designed to evaluate the status of the hormone receptors, human epide...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2010.08.026

    authors: Choi Y,Kim EJ,Seol H,Lee HE,Jang MJ,Kim SM,Kim JH,Kim SW,Choe G,Park SY

    更新日期:2012-01-01 00:00:00

  • Oncofetal protein IMP3: a useful diagnostic biomarker for leiomyosarcoma.

    abstract::An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2011.12.020

    authors: Cornejo K,Shi M,Jiang Z

    更新日期:2012-10-01 00:00:00

  • Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs.

    abstract::The ontogeny and distribution of the epidermal growth factor (EGF) receptor and lipocortin-1, a major cellular substrate of the EGF receptor, were evaluated in a developmental series of fetal and neonatal human lungs (8 to 41 weeks' gestation and stillborn to 16 days' postnatal age). The peroxidase anti-peroxidase tec...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(90)90127-q

    authors: Johnson MD,Gray ME,Carpenter G,Pepinsky RB,Stahlman MT

    更新日期:1990-02-01 00:00:00

  • Primitive neuroectodermal tumors of the central nervous system.

    abstract::Primitive neuroectodermal tumors are morphologically similar malignant tumors arising in intracranial and peripheral sites of the nervous system, showing varying degrees of cellular differentiation with a tendency to disseminate along cerebrospinal fluid pathways. They occur primarily in children and young adults. Und...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/s0046-8177(83)80006-9

    authors: Becker LE,Hinton D

    更新日期:1983-06-01 00:00:00

  • Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.

    abstract::It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2012.08.016

    authors: Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL

    更新日期:2013-05-01 00:00:00