Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement.

Abstract:

:Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that thoracoamniotic shunting can cause histologic changes in the cyst epithelia. In 5 of 8 patients treated prenatally with thoracoamniotic shunting, squamous metaplasia in the cyst epithelia was seen; whereas squamous metaplasia was not found in 6 patients who were not treated with this procedure. Our results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Matsuoka K,Hayashi S,Urano F,Zhu LJ,Okita H,Sago H,Nakazawa A

doi

10.1016/j.humpath.2011.10.017

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1413-7

issue

9

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(11)00459-X

journal_volume

43

pub_type

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