Invasive papillary adenocarcinoma of the colon.

Abstract:

:Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a superficial adenomatous component. The immunohistochemical stains showed that the tumor cells were negative for p27 and p53; both tumors were microsatellite stable, that is, with no microsatellite instability in the 6 markers studied, and there was no loss of the mismatch repair proteins hMSH2 or hMLH1. These findings suggest that these tumors follow the tumor-suppressor pathway and represent an aggressive subtype of colonic adenocarcinoma.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Palazzo JP,Edmonston TB,Chaille-Arnold LM,Burkholder S

doi

10.1053/hupa.2002.32228

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

372-5

issue

3

eissn

0046-8177

issn

1532-8392

pii

S0046817702812126

journal_volume

33

pub_type

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