Abstract:
:Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a superficial adenomatous component. The immunohistochemical stains showed that the tumor cells were negative for p27 and p53; both tumors were microsatellite stable, that is, with no microsatellite instability in the 6 markers studied, and there was no loss of the mismatch repair proteins hMSH2 or hMLH1. These findings suggest that these tumors follow the tumor-suppressor pathway and represent an aggressive subtype of colonic adenocarcinoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Palazzo JP,Edmonston TB,Chaille-Arnold LM,Burkholder Sdoi
10.1053/hupa.2002.32228subject
Has Abstractpub_date
2002-03-01 00:00:00pages
372-5issue
3eissn
0046-8177issn
1532-8392pii
S0046817702812126journal_volume
33pub_type
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