Abstract：
:Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series have analyzed the prognostic implications of complement glomerular deposits. This study aimed to assess the clinical and prognostic implications of C3d- and C4d-positive glomerular staining in renal vasculitis. Eighty-five patients with a diagnosis of pauci-immune necrotizing crescentic glomerulonephritis were included in the study. C3d and C4d were analyzed by immunohistochemical staining using a polyclonal antibody. The primary predictors were glomerular C3d- and C4d-positive staining. The primary end point was the cumulative percentage of patients who developed end-stage renal disease. Glomerular staining for C3d and C4d was observed in 42 (49.4%) of 85 biopsies and 38 (44.7%) of 85 biopsies, respectively. C3d-positive staining was associated with the severity of renal impairment and with a lower response rate to treatment (P=.003 and P=.04, respectively). Renal survival at 2 and 5 years was 60.9% and 51.8% in C3d-positive patients compared with 87.7% and 78.9% in C3d-negative patients (P=.04). C4d-positive staining did not show any impact in renal outcome. When adjusted by renal function and other histologic parameters, C3d staining remained as an independent predictor for renal survival (hazard ratio, 2.5; 95% confidence interval, 1.1-5.7; P=.03). Therefore, this study demonstrates that C3d-positive glomerular staining is an independent risk factor for the development of end-stage renal disease in ANCA-associated renal vasculitis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Villacorta J,Diaz-Crespo F,Acevedo M,Guerrero C,Campos-Martin Y,García-Díaz E,Mollejo M,Fernandez-Juarez Gdoi
10.1016/j.humpath.2016.05.015subject
Has Abstractpub_date
2016-10-01 00:00:00pages
31-9eissn
0046-8177issn
1532-8392pii
S0046-8177(16)30096-Xjournal_volume
56pub_type
杂志文章,多中心研究相关文献
HUMAN PATHOLOGY文献大全abstract：:The aims of this investigation were to compare quantitative with qualitative analysis of fluorescent in situ hybridization (FISH) centromere signals in interphase breast cancer cell nuclei and to evaluate the possible clinical utility of detecting numerical abnormalities of chromosomes 11 and 17 by FISH in the preoper...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90267-8
更新日期：1999-02-01 00:00:00
abstract：:Gene hypomethylation and hypermethylation can lead to a loss of genetic imprinting in malignancies. The mechanism responsible for overexpression of the imprinted insulin-like growth factor II (IGF2) gene has not been investigated in osteosarcoma. In this study, the expression levels, imprinting status, and the extent ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.03.003
更新日期：2009-10-01 00:00:00
abstract：:Pleomorphic adenoma (PA) is the most common benign tumor of salivary glands. Carcinomas in pleomorphic adenomas (CPAs) may arise by malignant transformation of the epithelial components of PAs. Occasionally, transitional zones containing cells with histological features intermediate between those of the benign PA and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90449-9
更新日期：1996-08-01 00:00:00
abstract：:Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were stu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90094-4
更新日期：1989-09-01 00:00:00
abstract：:Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. The lesions contain a tubular adenocarcinoma that seems to develop "hepatoid" features, but the relation between the tubular adenocarcinomatous and the hepatoid components remains unclear. We compa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.10.020
更新日期：2007-06-01 00:00:00
abstract：:The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for carcinomas of the large intestine are reported herein. ...
journal_title：Human pathology
pub_type： 指南,杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.11.018
更新日期：2008-08-01 00:00:00
abstract：:Lipomatous lesions of the heart involving the atria and interatrial septum are not well known. Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effec...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.04.028
更新日期：2006-10-01 00:00:00
abstract：:We report two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp and associated with allergic fungal sinusitis (AFS). Curvularia lunata was cultured in one case and Curvularia senegalensis was cultured in the other. Based on these cases and a review of the literature, we discuss unusual ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(91)90106-y
更新日期：1991-12-01 00:00:00
abstract：:Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.10.014
更新日期：2009-05-01 00:00:00
abstract：:Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and a known mediator of glucocorticoid-regulated inflammatory responses. Using a combined multiple high-throughput approach, we recently identified a reduced expression of ANXA1 in human breast cancer. The finding was confirmed at the gene level by quan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.06.001
更新日期：2006-12-01 00:00:00
abstract：:Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.02.001
更新日期：2006-07-01 00:00:00
abstract：:This study tested whether concordance could be achieved for abnormal inflammation in the basal decidua of placental specimens among 6 pathologists experienced in placental pathology. Thirty microscope slides were evaluated by the pathologists for chronic deciduitis. They also scored the severity and extent of inflamma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80241-5
更新日期：2000-03-01 00:00:00
abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2011.07.020
更新日期：2012-04-01 00:00:00
abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.016
更新日期：2012-09-01 00:00:00
abstract：:Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80467-1
更新日期：1986-04-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is an angiogenic factor that plays important roles in tumor growth. Angiogenesis studies on VEGF deal with various types of malignant tumors, but very little is known about the role or significance of VEGF in human thyroid neo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90241-1
更新日期：1999-08-01 00:00:00
abstract：:The introduction of chemotherapeutic agents directly into the proper hepatic artery via an indwelling catheter results in perfusion of the gallbladder, because the cystic artery is usually a branch of the right hepatic artery. Five gallbladders, removed two to 16 months after insertion of permanently implanted Infusai...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80275-6
更新日期：1985-10-01 00:00:00
abstract：:The objective of this cohort study was to evaluate whether the immunohistochemical expression of tissue inhibitor of metalloprotease 2, matrix metalloproteinase (MMP) 2, and MMP-9 could predict the occurrence of death and progression in women with ovarian high-grade serous carcinoma (HGSC). A total of 100 women with p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.01.014
更新日期：2015-05-01 00:00:00
abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2015.06.013
更新日期：2015-09-01 00:00:00
abstract：:The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80285-5
更新日期：1988-11-01 00:00:00
abstract：:Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.03.012
更新日期：2011-10-01 00:00:00
abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.005
更新日期：2015-01-01 00:00:00
abstract：:Atrial fibrillation becomes a self-perpetuating arrhythmia as a consequence of electrophysiologic and structural remodeling involving the atrium. Oxidative stress may be a link between this rhythm disturbance and electrophysiologic remodeling. The aim of this study was to evaluate whether the heme oxygenase-1 (HO-1) m...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.007
更新日期：2008-08-01 00:00:00
abstract：:Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a supe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.32228
更新日期：2002-03-01 00:00:00
abstract：:Bioassay of hormones has a small but important role in defining the physiologic status of selected patients in whom immunoassay results do not correlate with clinical signs and symptoms. This article reviews three sensitive bioassays for hormones, which are based on 1) stimulation of adenylate cyclase in membrane prep...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(84)80050-7
更新日期：1984-02-01 00:00:00
abstract：:Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90175-5
更新日期：1989-02-01 00:00:00
abstract：:The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80052-7
更新日期：1987-08-01 00:00:00
abstract：:Recently, a polymorphism in the hMSH2 DNA mismatch repair gene has been associated with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of interest because DNA mismatch repair defects result in alterations in microsatellite stability. The current study was designed to determine w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90293-9
更新日期：1999-01-01 00:00:00
