Recommendations for quality assurance and improvement in surgical and autopsy pathology.

abstract：:Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted t...

journal_title：Human pathology

authors： Silva Amancio AM,Cunha IW,Neves JI,Quetz JD,Carraro DM,Rocha RM,Zequi SC,Cubilla AL,da Fonseca FP,Lopes A,Cunha MD,Lima MV,Vassallo J,Guimarães GC,Soares FA

更新日期：2017-03-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...

journal_title：Human pathology

authors： Bhardwaj M,Sen S,Sharma A,Kashyap S,Chosdol K,Pushker N,Bajaj MS,Bakhshi S

更新日期：2015-10-01 00:00:00

abstract：:Although GATA binding protein 3, a zinc finger transcription factor and an estrogen receptor-regulated gene, has recently been suggested as a marker for urothelium, prognostic significance of GATA binding protein 3 expression in bladder tumor remains unclear. We immunohistochemically stained for GATA binding protein 3...

journal_title：Human pathology

authors： Miyamoto H,Izumi K,Yao JL,Li Y,Yang Q,McMahon LA,Gonzalez-Roibon N,Hicks DG,Tacha D,Netto GJ

更新日期：2012-11-01 00:00:00

abstract：:The proliferation marker mitotic activity index is the strongest prognostic indicator in lymph node-negative breast cancer. The World Health Organization (WHO) 2003-defined procedure for determining WHO-mitotic activity index is often replaced by a quick scan mitotic impression. We evaluated the prognostic consequence...

journal_title：Human pathology

authors： Skaland I,van Diest PJ,Janssen EA,Gudlaugsson E,Baak JP

更新日期：2008-04-01 00:00:00

abstract：:Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present st...

journal_title：Human pathology

authors： Mathai AM,Alexander J,Kuo FY,Torbenson M,Swanson PE,Yeh MM

更新日期：2013-08-01 00:00:00

abstract：:A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and d...

journal_title：Human pathology

authors： Kamel OW,Horoupian DS,Silverberg GD

更新日期：1989-12-01 00:00:00

abstract：:This article briefly describes the origin of one of the more common (food-related) pathologic terms--"bread and butter pericarditis." The eminent French physician, Laennec, the inventor of the stethoscope amongst several other important medical contributions, can be credited for having coined the term that is still in...

journal_title：Human pathology

authors： Cohen MB

更新日期：2004-02-01 00:00:00

abstract：:To investigate the expression and clinical significance of long noncoding RNA (lncRNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein-coding genes and lncRNAs in tumor and paired adjacent nontumor tissues. We found that 41 lncRNAs were up-regulated and 31 lncRNAs were down-r...

journal_title：Human pathology

authors： Li L,Wang YY,Mou XZ,Ye ZY,Zhao ZS

更新日期：2018-08-01 00:00:00

abstract：:The SHH signaling pathway is critical for gastrointestinal development and organic patterning, and dysregulation of SHH pathway molecules has been detected in multiple gastrointestinal neoplasms. This study investigated the role of the SHH signaling pathway in PJS. Expression of SHH, PTCH, and GLI1 was examined by rea...

journal_title：Human pathology

authors： Xu X,Su J,Li R,Wang Y,Zeng D,Wu B

更新日期：2016-04-01 00:00:00

abstract：:Digitization of histologic slides is associated with many advantages, and its use in routine diagnosis holds great promise. Nevertheless, few articles evaluate virtual microscopy in routine settings. This study is an evaluation of the validity and diagnostic performance of virtual microscopy in routine histologic diag...

journal_title：Human pathology

authors： Nielsen PS,Lindebjerg J,Rasmussen J,Starklint H,Waldstrøm M,Nielsen B

更新日期：2010-12-01 00:00:00

abstract：:Primary small bowel adenocarcinoma is rare. Although generally similar to colonic adenocarcinoma, some small bowel adenocarcinomas exhibit unique morphologic features, particularly those arising in association with Crohn disease. In this study, 15 sporadic small bowel adenocarcinomas and 11 Crohn enteritis-associated ...

journal_title：Human pathology

authors： Whitcomb E,Liu X,Xiao SY

更新日期：2014-02-01 00:00:00

abstract：:Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...

journal_title：Human pathology

authors： Fukutomi T,Hayashi Y,Emoto K,Kamiya K,Kohno M,Sakamoto M

更新日期：2013-09-01 00:00:00

abstract：:Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...

journal_title：Human pathology

authors： Hamanaka W,Motoi N,Ishikawa S,Ushijima M,Inamura K,Hatano S,Uehara H,Okumura S,Nakagawa K,Nishio M,Horai T,Aburatani H,Matsuura M,Iwasaki A,Ishikawa Y

更新日期：2014-05-01 00:00:00

abstract：:The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated ...

journal_title：Human pathology

authors： Cates JM,Black J,Wolfe CC,Shinohara ET,Holt GE,Keedy VL,Hande KR,Homlar KC,Halpern JL,Schwartz HS,Troutman A,Coffin CM

更新日期：2012-09-01 00:00:00

abstract：:Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma (HCC) with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated HCCs. In the current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immu...

journal_title：Human pathology

authors： Zhao CL,Hui Y,Wang LJ,Yang D,Yakirevich E,Mangray S,Huang CK,Lu S

更新日期：2018-10-01 00:00:00

abstract：:Multifocal/multicentric breast cancers are common. However, investigations of biomarkers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 in individual tumor foci of such cancers are rare. This study was designed to evaluate the status of the hormone receptors, human epide...

journal_title：Human pathology

authors： Choi Y,Kim EJ,Seol H,Lee HE,Jang MJ,Kim SM,Kim JH,Kim SW,Choe G,Park SY

更新日期：2012-01-01 00:00:00

abstract：:A 51-year-old man presented with a paratracheal tumor. He had undergone resection of a thyroid tumor 15 years previously; at that time, the histologic diagnosis had been anaplastic carcinoma. When the tumor recurred, the presumptive clinical diagnosis was medullary thyroid carcinoma. Histologic examination revealed a ...

journal_title：Human pathology

authors： Asa SL,Dardick I,Van Nostrand AW,Bailey DJ,Gullane PJ

更新日期：1988-12-01 00:00:00

abstract：:The presence of thyroglobulin (TG) was investigated by immunohistochemistry with one polyclonal and three distinct monoclonal anti-TG antibodies in 19 primary and 15 metastatic medullary thyroid carcinoma (MTC) cases. In two primary tumors possessing a mixed trabecular and follicular growth pattern, a significant numb...

journal_title：Human pathology

authors： de Micco C,Chapel F,Dor AM,Garcia S,Ruf J,Carayon P,Henry JF,Lebreuil G

更新日期：1993-03-01 00:00:00

abstract：:Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...

journal_title：Human pathology

authors： Annan AC,Stevens KA,Osunkoya AO

更新日期：2017-07-01 00:00:00

abstract：:Snail1 and ZEB1 are transcriptional repressors that drive tumor initiation and metastasis in animal models. Snail1 and ZEB1 are frequently coexpressed in tumor cell lines, suggesting that these factors may cooperate to promote tumor progression. However, coexpression of these transcriptional repressors in primary huma...

journal_title：Human pathology

authors： Geradts J,de Herreros AG,Su Z,Burchette J,Broadwater G,Bachelder RE

更新日期：2011-08-01 00:00:00

abstract：:A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age...

journal_title：Human pathology

authors： Ciscato A,Zare SY,Fadare O

更新日期：2020-06-01 00:00:00

abstract：:Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...

journal_title：Human pathology

authors： Turbat-Herrera EA,Knowles K

更新日期：1998-12-01 00:00:00

abstract：:Liver involvement in amyloidosis is rarely associated with intrahepatic cholestasis. The cases recorded in the literature indicate that there is a tendency toward periportal deposition, leading to centrilobular cholestasis. Our case was most interesting in that the amyloid deposition was most severe in the centrilobul...

journal_title：Human pathology

authors： Finkelstein SD,Fornasier VL,Pruzanski W

更新日期：1981-05-01 00:00:00

abstract：:Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...

journal_title：Human pathology

authors： Tsutsumi Y

更新日期：1989-09-01 00:00:00

abstract：:Astrocytoma grade IV (glioblastoma multiforme) is the most common and most malignant tumor of the central nervous system and is currently noncurable. Here, we have examined a population-based cohort of 47 patients with grade IV astrocytoma, who underwent tumor surgery at Sahlgrenska University Hospital in Sweden and w...

journal_title：Human pathology

authors： Skalli O,Wilhelmsson U,Orndahl C,Fekete B,Malmgren K,Rydenhag B,Pekny M

更新日期：2013-10-01 00:00:00

abstract：:A 48-year-old man with a history of recurrent urolithiasis and chronic renal failure underwent a nephrectomy for a renal mass. At surgery the mass proved to be a calculus impacted in a dilated calyx. Gross examination of the kidney revealed chalky white deposits in the deep medulla and papillary tips. Histologic exami...

journal_title：Human pathology

authors： Gelb AB,Fye KH,Tischfield JA,Sahota AS,Sparks JW,Hancock DC,Sibley RK

更新日期：1992-09-01 00:00:00

abstract：:Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that has morphologic features similar to secretory carcinoma of the breast and that also harbors the same ETV6 translocation. Diffuse mammaglobin and S-100 immunoreactivity are used to differentiate MASC from its morphologic mimic...

journal_title：Human pathology

authors： Patel KR,Solomon IH,El-Mofty SK,Lewis JS Jr,Chernock RD

更新日期：2013-11-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 c...

journal_title：Human pathology

authors： El-Zimaity HM,Genta RM,Graham DY

更新日期：1996-12-01 00:00:00

abstract：:Laminin and collagen have been studied in several tumor types and their immunomorphological expression correlated with tumor morphogenesis, local invasiveness, and metastatic behavior. In a series of 53 cases of pleomorphic adenomas (PA) and 16 cases of carcinomas ex-pleomorphic adenoma (Ca ex-PA), we investigated by ...

journal_title：Human pathology

authors： Félix A,Rosa JC,Fonseca I,Cidadão A,Soares J

更新日期：1999-08-01 00:00:00

abstract：:Cytochrome P-450 specific for steroid 17 alpha-hydroxylation (P-45017 alpha) was immunolocalized in normal and hyperfunctioning adrenal glands of pigs, bovines, and humans, using a specific IgG fraction raised against the enzyme. P-45017 alpha was present in the zona fasciculata (ZF) and zona reticularis (ZR), but not...

journal_title：Human pathology

authors： Sasano H,Mason JI,Sasano N

更新日期：1989-02-01 00:00:00