Respiratory obstruction caused by a multicentric granular cell tumor of the laryngotracheobronchial tree.

abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...

journal_title：Human pathology

authors： Yu J,Monaco SE,Onisko A,Bhargava R,Dabbs DJ,Cieply KM,Fine JL

更新日期：2013-03-01 00:00:00

abstract：:The relationship between nuclear diameter and biologic behavior was studied in 127 cases of thyroid carcinoma. Using a sonic digitizer coupled to a minicomputer, nuclear diameters of 200 randomly selected cancer cells from each case (hematoxylineosin-stained paraffin sections) projected at X 400 magnification were tra...

journal_title：Human pathology

authors： Lee TK,Myers RT,Bond MG,Marshall RB,Kardon B

更新日期：1987-12-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is known to have a wide variation in clinical outcome despite the use of conventional prognostic factors, such as staging or grading. A better knowledge of the biologic aggressiveness of RCC could facilitate the selection of patients at high risk of tumor progression. The aim of this study w...

journal_title：Human pathology

authors： Rioux-Leclercq N,Epstein JI,Bansard JY,Turlin B,Patard JJ,Manunta A,Chan T,Ramee MP,Lobel B,Moulinoux JP

更新日期：2001-11-01 00:00:00

abstract：:Four cases of clear cell lymphoma were studied by means of light and electron microscopy, enzyme-histochemistry, and E- and EAC-rosette formation. On light microscopic examination the tumors were seen to be composed mainly of round, oval, or slight irregular cells with water-clear, abundant cytoplasm. The neoplastic c...

journal_title：Human pathology

authors： Zhuang HG,Liang GZ,Li WC,Zhang YQ,Guo RZ,Liu SL,He NX

更新日期：1988-07-01 00:00:00

abstract：:Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (rang...

journal_title：Human pathology

authors： Li P,Zhang D,Zhou J,Li P,Shen Y,Pan Z,Evans AG,Liao X

更新日期：2020-12-01 00:00:00

abstract：:In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...

journal_title：Human pathology

authors： Stamm BH

更新日期：1984-07-01 00:00:00

abstract：:Papillary carcinoma of the breast is a variant of predominantly intraductal carcinoma characterized by a papillary growth pattern with fibrovascular support. Loss of heterozygosity (LOH) was evaluated at multiple chromosomal loci (including loci reported to show frequent genetic alterations in breast cancer) to determ...

journal_title：Human pathology

authors： Lininger RA,Park WS,Man YG,Pham T,MacGrogan G,Zhuang Z,Tavassoli FA

更新日期：1998-10-01 00:00:00

abstract：:We have recently noted a hitherto undescribed hepatic hemosiderosis confined to endothelial cells of the portal tract in chronic viral hepatitis. In this study, this lesion was surveyed in 156 liver biopsy specimens from patients with chronic hepatitis C and in 21 liver biopsy specimens from patients with chronic hepa...

journal_title：Human pathology

authors： Kaji K,Nakanuma Y,Sasaki M,Unoura M,Kobayashi K,Nonomura A

更新日期：1995-10-01 00:00:00

abstract：:A 33-year-old male runner, who had undergone a Swanson silastic prosthetic implant for degenerative joint disease of the first metatarsal head and proximal phalanx of the right great toe, presented with unilateral inguinal lymphadenopathy. Biopsy revealed confluent, non-caseating granulomas containing silastic materia...

journal_title：Human pathology

authors： Rogers LA,Longtine JA,Garnick MB,Pinkus GS

更新日期：1988-10-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major efforts is being made to identify molecular markers capable to differentiate oral potentially malignant lesions (OPMLs) with indolent course from lesions with aggressive behavior. We undertook a study to evaluate if gain of the human telomer...

journal_title：Human pathology

authors： Dorji T,Monti V,Fellegara G,Gabba S,Grazioli V,Repetti E,Marcialis C,Peluso S,Di Ruzza D,Neri F,Foschini MP

更新日期：2015-09-01 00:00:00

abstract：:The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...

journal_title：Human pathology

authors： Bonkhoff H,Stein U,Remberger K

更新日期：1993-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...

journal_title：Human pathology

authors： Rezk SA,Weiss LM

更新日期：2007-09-01 00:00:00

abstract：:Tissues obtained from 600 routine autopsies were studied. Mineral oil lipidosis was present in the spleen (76 per cent), liver (45 per cent), bone marrow (26 per cent), and lymph nodes; more than 50 per cent of the lymph nodes from the mesentery, porta hepatis, and mediastinum were affected. Mineral oil and its metabo...

journal_title：Human pathology

authors： Cruickshank B,Thomas MJ

更新日期：1984-08-01 00:00:00

abstract：:Enteroendocrine cell dysgenesis was observed in 3 patients with intestinal failure of unknown cause. Enteroendocrine cell dysgenesis is a congenitally acquired life-threatening malabsorptive condition with a unique clinical phenotype paired with a histologically identifiable disease pattern. Two cases were first prese...

journal_title：Human pathology

authors： Cortina G,Smart CN,Farmer DG,Bhuta S,Treem WR,Hill ID,Martín MG

更新日期：2007-04-01 00:00:00

abstract：:Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation has yet to...

journal_title：Human pathology

authors： Kasajima A,Papotti M,Ito W,Brizzi MP,La Salvia A,Rapa I,Tachibana T,Yazdani S,Sasano H,Volante M

更新日期：2018-02-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....

journal_title：Human pathology

authors： Pierson CR,Schober MS,Wallis T,Sarkar FH,Sorensen PH,Eble JN,Srigley JR,Jones EC,Grignon DJ,Adsay V

更新日期：2001-05-01 00:00:00

abstract：:Increasing differentiation in the human endometrium is associated with an apparent decrease in intercellular contacts between endometrial stromal cells ...

journal_title：Human pathology

authors： Parmley TH,Roberts DK,Emsa NJ,Horbelt DV

更新日期：1990-10-01 00:00:00

abstract：:Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...

journal_title：Human pathology

authors： Veinot JP,Gattinger DA,Fliss H

更新日期：1997-04-01 00:00:00

abstract：:Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carci...

journal_title：Human pathology

authors： Ramp U,Krieg T,Caliskan E,Mahotka C,Ebert T,Willers R,Gabbert HE,Gerharz CD

更新日期：2004-08-01 00:00:00

abstract：:The current system of pathologic classification of human breast cancers does not take into account the biologic determinants of prognosis, nor is there a consensus regarding the progression from in situ to invasive carcinoma. The present study compared the molecular phenotypes of in situ and invasive components of bre...

journal_title：Human pathology

authors： Martins D,Sousa B,Lopes N,Gomes M,Veronese L,Albergaria A,Paredes J,Schmitt F

更新日期：2011-10-01 00:00:00

abstract：:To investigate the possibility of human immunodeficiency virus-(HIV) 1 infection of liver cells, liver samples from 17 patients with either acquired immunodeficiency syndrome (AIDS, 13), AIDS-related complex (ARC, 3), or lymphadenopathy syndrome (LAS, 1) were studied. A monoclonal antibody directed against the p24 gag...

journal_title：Human pathology

authors： Housset C,Boucher O,Girard PM,Leibowitch J,Saimot AG,Bréchot C,Marche C

更新日期：1990-04-01 00:00:00

abstract：:Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...

journal_title：Human pathology

authors： Velez N,Jukic D,Ho J

更新日期：2008-09-01 00:00:00

abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

journal_title：Human pathology

authors： Michel RP,Limacher JJ,Kimoff RJ

更新日期：1982-01-01 00:00:00

abstract：:In a series of approximately 80,000 lymph nodes, amyloid deposition was found in 18; 12 of those nodes were selected, on the basis of availability of specimens, for investigation by immunohistochemical typing to identify the protein of origin and by correlation with morphologic criteria and clinical information. Four ...

journal_title：Human pathology

authors： Newland JR,Linke RP,Lennert K

更新日期：1986-12-01 00:00:00

abstract：:It remains unclear why Barrett esophagus (BE)-associated adenocarcinoma (EAC) frequently occurs in the 0 to 3 o'clock area of the BE. The aims of this study were to clarify the localization of specialized intestinal metaplasia (SIM) as a precancerous lesion and of molecular alterations among different locations using ...

journal_title：Human pathology

authors： Fukui S,Watari J,Tomita T,Yamasaki T,Okugawa T,Kondo T,Kono T,Tozawa K,Ikehara H,Ohda Y,Oshima T,Fukui H,Das KM,Miwa H

更新日期：2016-05-01 00:00:00

abstract：:In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...

journal_title：Human pathology

authors： Hong KO,Oh KY,Shin WJ,Yoon HJ,Lee JI,Hong SD

更新日期：2018-10-01 00:00:00

abstract：:The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue ...

journal_title：Human pathology

authors： Bogomoletz WV,Geboes K,Feydy P,Nasca S,Ectors N,Rigaud C

更新日期：1988-11-01 00:00:00

abstract：:Intraductal carcinoma of the prostate (IDC-P) and high-grade prostatic intraepithelial neoplasia (HGPIN) are two distinct intraductal lesions; the former is usually associated with invasive carcinoma and has an aggressive course while the latter is considered a precancerous lesion. In addition, there are morphological...

journal_title：Human pathology

authors： Miyai K,Divatia MK,Shen SS,Miles BJ,Ayala AG,Ro JY

更新日期：2014-08-01 00:00:00

abstract：:Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were stu...

journal_title：Human pathology

authors： Tosi P,Baak JP,Luzi P,Miracco C,Lio R,Barbini P

更新日期：1989-09-01 00:00:00

abstract：:Geotrichum candidum was identified as an invasive organism in the terminal ileum of a man with "hairy cell" leukemia. The organism was identified on the basis of histologic and cultural characteristics. The diagnostic features of G. candidum infection are compared to those of Aspergillus and Candida species. ...

journal_title：Human pathology

authors： Jagirdar J,Geller SA,Bottone EJ

更新日期：1981-07-01 00:00:00