Renal amyloidosis characterized by abnormally thick fibrils.

abstract：:Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer. Studies on Western and Japanese lung cancers have indicated substantial differences in the EGFR mutation frequency between these populations. To investigate the prev...

journal_title：Human pathology

authors： Al-Kuraya K,Siraj AK,Bavi P,Al-Jommah N,Ezzat A,Sheikh S,Amr S,Al-Dayel F,Simon R,Guido S

更新日期：2006-04-01 00:00:00

abstract：:Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...

journal_title：Human pathology

authors： Dare AJ,Veinot JP,Edwards WD,Tazelaar HD,Schaff HV

更新日期：1993-12-01 00:00:00

abstract：:Thromboangiitis obliterans (Buerger's disease) is an uncommon variety of occlusive peripheral vascular disease, occurring predominantly in young male tobacco smokers. The vascular lesion in the acute stage of thromboangiitis obliterans is distinctive and affects both the arteries and veins. Described here is an unusua...

journal_title：Human pathology

authors： Lie JT

更新日期：1987-04-01 00:00:00

abstract：:Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower...

journal_title：Human pathology

authors： Magro G,Righi A,Casorzo L,Antonietta T,Salvatorelli L,Kacerovská D,Kazakov D,Michal M

更新日期：2012-11-01 00:00:00

abstract：:Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that has morphologic features similar to secretory carcinoma of the breast and that also harbors the same ETV6 translocation. Diffuse mammaglobin and S-100 immunoreactivity are used to differentiate MASC from its morphologic mimic...

journal_title：Human pathology

authors： Patel KR,Solomon IH,El-Mofty SK,Lewis JS Jr,Chernock RD

更新日期：2013-11-01 00:00:00

abstract：:A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high...

journal_title：Human pathology

authors： Moysset I,Lloreta J,Miguel A,Vadell C,Ribalta T,Estrach T,Serrano S

更新日期：1997-10-01 00:00:00

abstract：:Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tiss...

journal_title：Human pathology

authors： Oyer CE,Cai R,Coughlin JJ,Singer DB

更新日期：1998-01-01 00:00:00

abstract：:Cancer cells show a higher rate of anaerobic respiration than normal cells. The exact mechanisms for this higher glycolysis rate in cancer cells remain to be elucidated. The results of recent studies have indicated that p53, the most commonly mutated tumor suppressor gene, may have important functions in the regulatio...

journal_title：Human pathology

authors： Won KY,Lim SJ,Kim GY,Kim YW,Han SA,Song JY,Lee DK

更新日期：2012-02-01 00:00:00

abstract：:The genetic diagnosis of Gaucher disease by molecular methods is complicated by the existence of a highly homologous transcribed pseudogene (96% identity) that is found in close proximity to the true gene on chromosome 1q21. In addition, the pseudogene sequence can mimic disease-causing mutations in the true gene. Sel...

journal_title：Human pathology

authors： Mohan D,Rolston R,Pal R,Swalsky PA,Sasatomi E,Lee RE,Finkelstein SD

更新日期：2004-04-01 00:00:00

abstract：:The use of interleukin-2 (IL-2), either alone or in combination with lymphokine-activated killer cells, tumor infiltrating lymphocytes, or other immunotherapeutic agents has added a new list of alternatives to conventional antineoplastic regimens. Little information is available about the pathologic changes occurring ...

journal_title：Human pathology

authors： Kragel AH,Travis WD,Feinberg L,Pittaluga S,Striker LM,Roberts WC,Lotze MT,Yang JJ,Rosenberg SA

更新日期：1990-05-01 00:00:00

abstract：:A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms. In this series, CMFs were found in patients of all age groups, with no predominance between sexes. Long bone tumors wer...

journal_title：Human pathology

authors： Zillmer DA,Dorfman HD

更新日期：1989-10-01 00:00:00

abstract：:In situ carcinomas must penetrate their own basement membrane to be classified as invasive, and subsequently infiltrate surrounding connective tissue and cross vascular basement membranes to metastasize hematogenously. Accordingly, in many studies, integral basement membrane components, including type IV collagen, lam...

journal_title：Human pathology

authors： Amenta PS,Briggs K,Xu K,Gamboa E,Jukkola AF,Li D,Myers JC

更新日期：2000-03-01 00:00:00

abstract：:It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...

journal_title：Human pathology

authors： Canet B,Pons C,Espinosa I,Prat J

更新日期：2012-05-01 00:00:00

abstract：:Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...

journal_title：Human pathology

authors： Ni H,Zhang XP,Wang XT,Xia QY,Lv JH,Wang X,Shi SS,Li R,Zhou XJ,Rao Q

更新日期：2016-12-01 00:00:00

abstract：:Syndecan-1, a cell-surface transmembrane heparan sulfate proteoglycan, has been reported to correlate with the biologic behavior of malignant tumors in various organs. We examined the correlation between the expression of syndecan-1 at the protein and mRNA levels and clinicopathologic features of 37 intrahepatic chola...

journal_title：Human pathology

authors： Harada K,Masuda S,Hirano M,Nakanuma Y

更新日期：2003-09-01 00:00:00

abstract：:Brain metastases (BMs) are common complications of adenocarcinomas (ADCs) of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin (mTOR) can influence the metastatic potential of various tumors, the role of mTOR c...

journal_title：Human pathology

authors： Krencz I,Sebestyén A,Fábián K,Márk Á,Moldvay J,Khoor A,Kopper L,Pápay J

更新日期：2017-04-01 00:00:00

abstract：:Epidermal growth factor receptor is a transmembrane receptor involved in oncogenesis, including the development of glioblastoma. We studied the prognostic significance of epidermal growth factor receptor amplification as determined by fluorescence in situ hybridization, quantitative polymerase chain reaction, and prot...

journal_title：Human pathology

authors： Coulibaly B,Nanni I,Quilichini B,Gaudart J,Metellus P,Fina F,Boucard C,Chinot O,Ouafik L,Figarella-Branger D

更新日期：2010-06-01 00:00:00

abstract：:Retrovenous perfusion of the myocardium via the coronary sinus and cardiac veins was one of the earliest attempted forms of myocardial revascularization. Although coronary artery revascularization has almost completely replaced venous revascularization as the procedure of choice, the latter approach is still occasiona...

journal_title：Human pathology

authors： Tickman RJ,Gravanis MB,Hunter SB

更新日期：1989-08-01 00:00:00

abstract：:Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...

journal_title：Human pathology

authors： Kleinschmidt-Demasters BK,Evans LC,Bobak JB,Lopez-Uribe D,Hopper D,Shroyer AL,Shroyer KR

更新日期：2000-08-01 00:00:00

abstract：:Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved...

journal_title：Human pathology

authors： Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

更新日期：2017-02-01 00:00:00

abstract：:This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the...

journal_title：Human pathology

authors： Sinclair RA,Antonovych TT,Mostofi FK

更新日期：1976-09-01 00:00:00

abstract：:Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...

journal_title：Human pathology

authors： Bruch JF,Sibony O,Benali K,Challier JC,Blot P,Nessmann C

更新日期：1997-10-01 00:00:00

abstract：:The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...

journal_title：Human pathology

authors： Bonkhoff H,Stein U,Remberger K

更新日期：1993-03-01 00:00:00

abstract：:Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...

journal_title：Human pathology

authors： Velez N,Jukic D,Ho J

更新日期：2008-09-01 00:00:00

abstract：:Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...

journal_title：Human pathology

authors： Ogawa T,Nagashima Y,Wada H,Akimoto K,Chiba Y,Nagatani T,Inayama Y,Yao M,Aoki I,Ikezawa Z

更新日期：2005-12-01 00:00:00

abstract：:Previous studies have proven that the lepidic component of lung adenocarcinoma is an independent prognostic factor and has a favorable effect on patient prognosis; however, no studies have reported the specific distribution of the lepidic component in lung cancer. In this study, we focused mainly on whether the lepidi...

journal_title：Human pathology

authors： Bian T,Jiang D,Feng J,Liu J,Qian L,Zhang Q,Li X,Liu Y,Zhang J

更新日期：2019-01-01 00:00:00

abstract：:Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...

journal_title：Human pathology

authors： Tobi M,Kaila V,Hassan N,Gallinger S,Fligiel S,Hatfield J,Gesell M,Sakr W,Luk G,Odze RD

更新日期：1999-04-01 00:00:00

abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...

journal_title：Human pathology

authors： Wang J,Li G,Ma H,Bao Y,Wang X,Zhou H,Sheng Z,Sugimura H,Jin J,Zhou X

更新日期：2007-11-01 00:00:00

abstract：:Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjace...

journal_title：Human pathology

authors： Aihara M,Truong LD,Dunn JK,Wheeler TM,Scardino PT,Thompson TC

更新日期：1994-08-01 00:00:00

abstract：:Disruptions of the p16-CDK4/cyclin D1-pRb pathway (RB pathway) and the p14ARF-MDM2-p53 pathway (p53 pathway) are important mechanisms in the development of human malignancies. In this study, we investigated RB and p53 pathways in 46 epithelial ovarian cancers (EOCs). In the RB pathway, 16 (34.8%) of 46 cases had p16 g...

journal_title：Human pathology

authors： Hashiguchi Y,Tsuda H,Yamamoto K,Inoue T,Ishiko O,Ogita S

更新日期：2001-09-01 00:00:00