Abstract:
:Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy with a poor prognosis, and pathologically, it is a diagnosis of exclusion. Rendering this diagnosis can be challenging in practice because of the large number of diverse entities in the differential diagnosis. We encountered an index case of a sinonasal carcinoma otherwise diagnosable as SNUC which, on further investigation, demonstrated strong and diffuse P16 expression, as well as diffuse expression of high-risk human papillomavirus (hrHPV) RNA by in situ hybridization (ISH). We therefore hypothesized that a subset of cases previously diagnosed as SNUC may in fact harbor transcriptionally active hrHPV. We further investigated a cohort of 25 SNUC cases in our pathology archives and performed ISH for hrHPV RNA on cases that demonstrated >70% nuclear and cytoplasmic P16 expression, criteria which, in other anatomic sites, correlates strongly with the presence of hrHPV. Twelve of 25 SNUC cases were P16 positive, and of these, 5 were positive for hrHPV by ISH. Thus, 20% of all SNUC cases in this cohort harbored transcriptionally active hrHPV. Herein, we report a clinical and pathologic analysis of these cases, including differential diagnostic considerations and comparison of their clinical behavior with SNUC cases that are negative for hrHPV by ISH.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Baraban E,Tong CCL,Adappa ND,Cooper Kdoi
10.1016/j.humpath.2020.05.002subject
Has Abstractpub_date
2020-07-01 00:00:00pages
64-69eissn
0046-8177issn
1532-8392pii
S0046-8177(20)30089-7journal_volume
101pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.006
更新日期:2013-10-01 00:00:00
abstract::Cytogenetic analysis of short-term cultures from 34 benign colorectal polyps, all histologically verified as adenomas, revealed clonal chromosome aberrations in 21 of them. Eight polyps had structural rearrangements, whereas only numerical changes were found in 13. A combination of structural and numerical chromosomal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90314-7
更新日期:1996-11-01 00:00:00
abstract::Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors. The present study was undertaken to determine the usefulness of the Ki-67 index and the corresponding tumor grade in predicting progression-free surviv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.06.011
更新日期:2012-04-01 00:00:00
abstract::Cardiac troponin T (cTnT) is considered as a specific marker for acute myocardial infarction. Here, we present a case with elevated cTnT, determined by a third-generation assay, without signs of a myocardial lesion. Routine investigation of a 66-year-old female patient with indolent B-cell lymphoma revealed increased ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.06.009
更新日期:2005-08-01 00:00:00
abstract::Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.02.008
更新日期:2013-09-01 00:00:00
abstract::Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.08.004
更新日期:2015-12-01 00:00:00
abstract::There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material. One hundred consecutive prostate cancers on needle biopsy were sent because of diagnosti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.001
更新日期:2005-11-01 00:00:00
abstract::Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.009
更新日期:2006-09-01 00:00:00
abstract::Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.017
更新日期:2012-09-01 00:00:00
abstract::Hemangiopericytoma and fibrosarcoma represented at one time two of the most common diagnoses in soft tissue pathology. Both terms are now largely extinct. This article will review the clinicopathologic, immunohistochemical and molecular genetic advances that have led to these changes, and review the pathologic feature...
journal_title:Human pathology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.humpath.2019.10.001
更新日期:2020-01-01 00:00:00
abstract::Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.006
更新日期:2018-02-01 00:00:00
abstract::Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial cells. Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.012
更新日期:2018-01-01 00:00:00
abstract::Graduate training is one of the most important activities in which we engage. Through PhD training programs in pathology, we continually renew the intellectual vigor of our discipline and assure its position as a vibrant force in the life sciences. To focus on this important issue, the Education Committee of the Ameri...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2004.03.014
更新日期:2004-07-01 00:00:00
abstract::Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.24323
更新日期:2001-05-01 00:00:00
abstract::Endomyocardial biopsies from right, left, or both ventricles were performed in 13 angiographically documented cases of endomyocardial fibrosis. The endocardium was appreciably thickened due to acellular hyalinized collagen tissue in all cases. Variable amounts of elastic tissue intimately admixed with fibrous tissue w...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90007-6
更新日期:1990-06-01 00:00:00
abstract::Digitization of histologic slides is associated with many advantages, and its use in routine diagnosis holds great promise. Nevertheless, few articles evaluate virtual microscopy in routine settings. This study is an evaluation of the validity and diagnostic performance of virtual microscopy in routine histologic diag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.05.015
更新日期:2010-12-01 00:00:00
abstract::The use of prosthetic implants for breast augmentation has become commonplace. Although implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report 2 cases of breast implant capsule-associated squamous cell carcinoma with poor clinical ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.07.011
更新日期:2017-09-01 00:00:00
abstract::A membrane-bound, Ca2-dependent complex of the cofactor factor Va and the enzyme factor Xa comprises the prothrombinase coagulation complex, which catalyzes the proteolytic conversion of prothrombin to thrombin. In normal hemostasis, the platelet is presumed to supply the surface membrane and thus constitutes the site...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80334-9
更新日期:1987-02-01 00:00:00
abstract::Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.01.012
更新日期:2006-06-01 00:00:00
abstract::Microsatellite instability (MSI) defines a specific type of genetic instability. Although consensus diagnostic criteria for MSI definition in colorectal cancer have been established, their utility in other tumor types remain to be proven. Previously we developed a mathematical model for MSI definition in colorectal ca...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.10.021
更新日期:2004-03-01 00:00:00
abstract::Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80467-1
更新日期:1986-04-01 00:00:00
abstract::One hundred six liver biopsy specimens from 34 orthotopic liver transplant (OLT) patients were examined and the histologic findings correlated with the clinical course of the patients to determine if specific morphologic patterns were associated with specific causes of acute allograft dysfunction. The principle causes...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80268-5
更新日期:1988-07-01 00:00:00
abstract::This study explored the importance of hepatitis B virus infection in cholangiocarcinoma pathogenesis in northern China. The clinical data of 66 patients with cholangiocarcinoma were analyzed. The hepatitis B virus gene was amplified using nested polymerase chain reaction, and the hepatitis B virus-related antigen was ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.04.004
更新日期:2012-01-01 00:00:00
abstract::Telomerase is a ribonucleoprotein enzyme associated with cellular immortality and has been detected in the vast majority of adult tumors. Wilms tumor is a histologically diverse embryonal malignancy of childhood, and the histological features of Wilms tumor and its precursor lesion, the nephrogenic rest, recapitulate ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90072-7
更新日期:1998-05-01 00:00:00
abstract::Schistosoma haematobium infection is a common occurrence in Africa and the Middle East and is the world's leading cause of hematuria. Since more North Americans are venturing into endemic areas and more residents of endemic areas are seeking medical care in North America, pathologists must be able not only to diagnose...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80456-7
更新日期:1986-04-01 00:00:00
abstract::The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90258-q
更新日期:1991-11-01 00:00:00
abstract::Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.012
更新日期:2004-10-01 00:00:00
abstract::A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80099-3
更新日期:1982-11-01 00:00:00
abstract::Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90056-m
更新日期:1993-01-01 00:00:00
abstract::A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the maligna...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.05.021
更新日期:2009-03-01 00:00:00