Abstract：
:Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but under other names such as hobnail features or oncocytic and, therefore, is poorly understood, and reported cases are few. We report the clinicopathologic features of 7 cases obtained from a cohort of 496 papillary thyroid carcinomas, which corresponds to a prevalence of 1.4%. The proportion of the micropapillary component accounted for between 5% and 20% of the tumors, was slightly more prevalent in men, correlated with the presence of lymphovascular permeation, and, in the survival analysis, showed lower survival (even at a short follow-up, 8.5 years) than conventional carcinoma without this component (P = .001); this is consistent with poor overall survival in the short term (2-5 years) reported for carcinomas with micropapillary pattern of other locations. We believe that owing to this difference in survival (>95% of patients with conventional papillary carcinoma are alive at 8.5 years versus 42% of those having at least 5% of micropapillary pattern), the micropapillary pattern should be correctly identified and stated in the pathology report when comprising at least 5% of the tumor.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Lino-Silva LS,Domínguez-Malagón HR,Caro-Sánchez CH,Salcedo-Hernández RAdoi
10.1016/j.humpath.2011.10.027subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1596-600issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(11)00490-4journal_volume
43pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Perineural invasion is a histologic feature usually diagnostic of invasion in malignancies. In the breast, however, it has been associated with benign lesions such as sclerosing adenosis (SA), complex sclerosing lesion/radial scar (CSL/RS), and ductal carcinoma in situ (DCIS). This article describes perineural invasio...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.27637
更新日期：2001-08-01 00:00:00
abstract：:In a large-scale analysis of gene expression in pancreatic cancer, we isolated the homologue of the mouse Rab20. The mouse protein was previously identified during a search for novel Rab proteins, a family of small GTP-binding proteins involved in the regulation of intracellular vesicular transport. The Rab20 protein ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.10.017
更新日期：2006-03-01 00:00:00
abstract：:Gastrointestinal stromal tumors are a group of mesenchymal tumors arising from the wall of the gastrointestinal tract that are characterized by activating mutations in KIT or PDGFRA. Their proper recognition is important clinically because of their potential responsiveness to targeted therapies. We report a case of du...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.09.017
更新日期：2009-04-01 00:00:00
abstract：:A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90017-8
更新日期：1989-05-01 00:00:00
abstract：:The expression of the proteins encoded by the ras, myc, and erb B-2 oncogenes was examined in 63 paraffin-embedded human cholangiocarcinomas of Thai and English origin using immunohistochemistry. The observed distributions were compared with oncogene expression in a series of human hepatocellular carcinomas. In an att...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(89)80006-1
更新日期：1989-12-01 00:00:00
abstract：:α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.04.025
更新日期：2013-10-01 00:00:00
abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90040-0
更新日期：1999-10-01 00:00:00
abstract：:The distinction of malignant mesothelioma from non-small-cell lung carcinoma (NSCLC) usually requires immunohistochemistry, but some broad-spectrum carcinoma markers stain mesotheliomas, and it remains unclear which broad-spectrum markers are most valuable for distinguishing these malignancies. Here, we directly compa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.04.005
更新日期：2020-06-01 00:00:00
abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80251-7
更新日期：1982-12-01 00:00:00
abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：:A case of apocrine carcinoma of the breast with psammoma bodies is described in a 69 year old man. The report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of psammoma bodies. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80178-5
更新日期：1981-08-01 00:00:00
abstract：:Studies on melanoma cell lines indicate the expression of actin-binding protein (ABP), a peripheral cytoplasmic protein that crosslinks actin, is important for melanoma cell motility. We used an ABP-specific monoclonal antibody to characterize ABP expression in 18 benign nevi and 28 primary and metastatic malignant me...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90305-0
更新日期：1994-07-01 00:00:00
abstract：:Fibroepithelial lesions (FEL) of the breast are notoriously difficult to classify on core needle biopsies. The goal of this study was to evaluate interobserver variability and accuracy of subclassifying difficult FELs into fibroadenoma (FA) and phyllodes tumors (PTs). We identified 50 breast core needle biopsies, init...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.001
更新日期：2016-01-01 00:00:00
abstract：:The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.11.022
更新日期：2019-04-01 00:00:00
abstract：:In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.11.012
更新日期：2016-04-01 00:00:00
abstract：:GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.11.014
更新日期：2010-07-01 00:00:00
abstract：:Collapsing glomerulopathy (CG), an aggressive variant of focal segmental glomerular sclerosis, is a renal disease with severe proteinuria and rapidly progressive renal failure. The pathogenesis of CG is unknown. It strongly resembles human immunodeficiency virus (HIV)-associated nephropathy, but the patients are HIV n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.124333
更新日期：2002-04-01 00:00:00
abstract：:Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90023-5
更新日期：1998-12-01 00:00:00
abstract：:Primary dermal melanoma (PDM) is a rare variant of melanoma which simulates metastatic melanoma to the skin. Diagnosis of PDM cannot be established on histologic grounds alone but requires absence of evidence of melanoma elsewhere by clinical history and/or imaging studies. Despite this entity being clinically well do...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.002
更新日期：2020-12-01 00:00:00
abstract：:Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7636
更新日期：2000-07-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.08.004
更新日期：2008-03-01 00:00:00
abstract：:Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified cl...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.23523
更新日期：2001-04-01 00:00:00
abstract：:A carcinoma of the urinary bladder with a distinct choriocarcinomatous component that developed in a postmenopausal woman was associated with high titers of circulating chorionic gonadotropin. The diagnosis was supported by histochemical demonstration of human chorionic gonadotropin in syncytial tumor giant cells and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80173-2
更新日期：1984-08-01 00:00:00
abstract：:Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90124-7
更新日期：1999-04-01 00:00:00
abstract：:A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.20411
更新日期：2000-12-01 00:00:00
abstract：:The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80170-0
更新日期：1981-08-01 00:00:00
abstract：:Recent studies have indicated that some cases of fulminant hepatitis that were ostensibly type B were actually acute viral hepatitis, types B and delta, or persistent hepatitis, type B with superimposed acute delta infection. Histologic characterization of the various types has not yet been undertaken. Within ten to 3...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80012-5
更新日期：1985-03-01 00:00:00
abstract：:Implementation of Grade Groups (GrGrs) has been widely accepted for reporting prostate cancer grade since the 2014 International Society of Urological Pathology consensus meeting. Despite their undisputed value for risk stratification, some GrGr are, a priori, quite heterogeneous in that they contain multiple Gleason ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.03.001
更新日期：2020-05-01 00:00:00
abstract：:Enteroendocrine cell dysgenesis was observed in 3 patients with intestinal failure of unknown cause. Enteroendocrine cell dysgenesis is a congenitally acquired life-threatening malabsorptive condition with a unique clinical phenotype paired with a histologically identifiable disease pattern. Two cases were first prese...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.10.014
更新日期：2007-04-01 00:00:00
abstract：:Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.003
更新日期：2013-10-01 00:00:00
