Abstract:
:Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen deposition, and this mechanism was confirmed. However, two additional mechanisms that also contributed to the interstitial thickening were identified. One, which was not described previously, involves folding of portions of alveolar septa or collapse of entire alveoli and permanent apposition of their walls. This process occurred in areas that had been denuded of alveolar lining epithelium. Granular pneumocytes attempting to re-epithelialize the denuded basal lamina proliferated over the surface of apposed septa, thereby combining the folded or collapsed alveoli and forming a single thickened septum. The second mechanism involves incorporation of intra-alveolar exudates into alveolar septa. It occurred when granular pneumocytes re-epithelialized along the luminal surface of intra-alveolar debris overlying denuded alveolar epithelial basal laminae. The relative importance of each of these mechanisms in the pathogenesis of interstitial fibrosis and their role in the more common chronic interstitial pneumonias are unknown. However, their recognition may inspire new approaches for the prevention and treatment of interstitial fibrosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Katzenstein ALdoi
10.1016/s0046-8177(85)80279-3subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1015-24issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(85)80279-3journal_volume
16pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.12
更新日期:2003-02-01 00:00:00
abstract::Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.01.013
更新日期:2006-05-01 00:00:00
abstract::AT-rich interactive domain 1A (ARID1A) is tumor suppressor gene that interacts with BRG1 adenosine triphosphatase to form a SWI/SNF chromatin remodeling protein complex. Inactivation of ARID1A has been described in several neoplasms, including epithelial ovarian and endometrial carcinomas, and has been correlated with...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.07.003
更新日期:2014-11-01 00:00:00
abstract::Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examina...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90401-n
更新日期:1992-08-01 00:00:00
abstract::Two undifferentiated (embryonal) sarcomas of liver were studied ultrastructurally and immunohistochemically. Electron microscopic examination of the pleomorphic tumor cells revealed fibroblastic and histiocytic characteristics. There were no specific findings to support rhabdomyoblastic, leiomyoblastic, or epithelial ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80154-4
更新日期:1985-07-01 00:00:00
abstract::A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms. In this series, CMFs were found in patients of all age groups, with no predominance between sexes. Long bone tumors wer...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90267-0
更新日期:1989-10-01 00:00:00
abstract::Angiogenesis is important for tumor growth and progress, and the intratumor density of microvessels is a significant prognostic factor in many tumor types. The role in thyroid cancer has not been well studied, and we therefore examined a series of 128 papillary carcinomas with respect to microvessel density (MVD) and ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/1-ip.2000.6548
更新日期:2000-04-01 00:00:00
abstract::Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bon...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80178-3
更新日期:1988-06-01 00:00:00
abstract::The DNA content of both fresh and formalin-fixed, paraffin-embedded tissues from 30 solid neoplasms was analyzed by flow cytometry. Cells from a single paraffin block of each tumor were disaggregated according to the method of Hedley et al. Cells were sampled from multiple sites of each fresh specimen. Fresh and depar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80521-5
更新日期:1988-03-01 00:00:00
abstract::Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90121-6
更新日期:1998-04-01 00:00:00
abstract::Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90041-m
更新日期:1991-02-01 00:00:00
abstract::Atrial fibrillation becomes a self-perpetuating arrhythmia as a consequence of electrophysiologic and structural remodeling involving the atrium. Oxidative stress may be a link between this rhythm disturbance and electrophysiologic remodeling. The aim of this study was to evaluate whether the heme oxygenase-1 (HO-1) m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.12.007
更新日期:2008-08-01 00:00:00
abstract::Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes ("disordered proliferative" and "anovulatory" patterns), and stromal breakdown. We reviewe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.002
更新日期:2007-04-01 00:00:00
abstract::A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.03.005
更新日期:2020-06-01 00:00:00
abstract::Histologic prognostic parameters in papillary renal cell carcinoma (PRCC) are unclear. The aims were to review the clinicopathological features of PRCC, including Fuhrman grade and International Society of Urological Pathology (ISUP) nucleolar grade, and to identify parameters that may be independent prognostic indica...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.07.001
更新日期:2015-10-01 00:00:00
abstract::We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique. A series of 90 cases of human breast carcinoma was ana...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90060-8
更新日期:1995-03-01 00:00:00
abstract::The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.11.002
更新日期:2012-09-01 00:00:00
abstract::Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.12.008
更新日期:2014-05-01 00:00:00
abstract::This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.11.005
更新日期:2005-02-01 00:00:00
abstract::Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(98)90003-x
更新日期:1998-12-01 00:00:00
abstract::This article considers the NHS cervical screening program and the controversies which have attended the introduction of comprehensive screening in a partially screened population of women in whom the underlying risk of disease was unknown. The increase in screening coverage which has taken place since 1988 has coincid...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(97)90094-0
更新日期:1997-02-01 00:00:00
abstract::Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80022-7
更新日期:1983-03-01 00:00:00
abstract::Cardiac troponin T (cTnT) is considered as a specific marker for acute myocardial infarction. Here, we present a case with elevated cTnT, determined by a third-generation assay, without signs of a myocardial lesion. Routine investigation of a 66-year-old female patient with indolent B-cell lymphoma revealed increased ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.06.009
更新日期:2005-08-01 00:00:00
abstract::Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90251-3
更新日期:1997-10-01 00:00:00
abstract::Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80467-1
更新日期:1986-04-01 00:00:00
abstract::We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80101-3
更新日期:1976-09-01 00:00:00
abstract::The immunohistologic distribution of the basement membrane components, type IV collagen and laminin, was evaluated in 57 alcohol-fixed, paraffin-embedded tissue sections which demonstrated immunostaining patterns with antigen preservation similar to that of frozen tissue sections. Normal and hyperplastic squamous muco...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80221-6
更新日期:1987-10-01 00:00:00
abstract::The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80170-0
更新日期:1981-08-01 00:00:00
abstract::Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1053/hupa.2003.35
更新日期:2003-03-01 00:00:00
abstract::Epithelioid hemangioendotheliomas are uncommon vascular tumors, mainly observed in lung and soft tissues. Liver involvement is infrequent and, in contrast to the extrahepatic localizations of the tumor, has not been subjected to detailed ultrastructural analysis. This prompted us to report the results of the ultrastru...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90155-x
更新日期:1989-07-01 00:00:00