当前位置： SCI文献检索 > HUMAN PATHOLOGY期刊下所有文献 > Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins.

Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins.

Abstract：

:In situ carcinomas must penetrate their own basement membrane to be classified as invasive, and subsequently infiltrate surrounding connective tissue and cross vascular basement membranes to metastasize hematogenously. Accordingly, in many studies, integral basement membrane components, including type IV collagen, laminin, and heparan sulfate proteoglycan, have been localized in a spectrum of tumors to gain insight into their role in neoplasia. A number of recently identified extracellular matrix molecules and isoforms of the aforementioned proteins have been localized to the basement membrane zone, illustrating another level of biochemical heterogeneity in these structures. As the complexity of these matrices becomes more apparent, their roles in maintaining homeostasis and in tumor biology falls into question. Of the new group of collagens localized to the basement membrane zone, type XV was the first to be characterized (Cell Tissue Res, 286:493-505, 1996). This nonfibrillar collagen has a nearly ubiquitous distribution in normal human tissues via a strong association with basement membrane zones, suggesting that it functions to adhere basement membrane to the underlying stroma. To begin investigation of this protein in malignant tumors, we have localized type XV in human colonic adenocarcinomas and compared its distribution with that of type IV collagen and laminin. Collagens XV and IV and laminin were found in all normal and colonic epithelial, muscle, fat, neural, and vascular basement membrane zones, as shown previously. In moderately differentiated, invasive adenocarcinomas, laminin and type IV collagen were sometimes observed as continuous, linear deposits around some of the malignant glands, but more often they were seen in either discontinuous deposits or were completely absent. In contrast, type XV collagen was characterized as virtually absent from the basement membrane zones of malignant glandular elements in moderately differentiated tumors. Nevertheless there were also similarities; all 3 proteins were usually present in the stroma and adjacent vascular basement membrane zones surrounding invasive glands. The loss of type XV collagen from these malignant epithelial basement membrane zones and its increased interstitial expression suggests a role for this protein in the invasive process and the possibility that it may provide a sensitive indicator of tumor invasion.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Amenta PS,Briggs K,Xu K,Gamboa E,Jukkola AF,Li D,Myers JC

doi

10.1016/s0046-8177(00)80251-8

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

359-66

issue

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(00)80251-8

journal_volume

pub_type

杂志文章

在线工具

Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins.