Abstract:
:Four human fetuses with the limb body wall malformation complex, also known as the amniotic band syndrome, were examined. Besides malformations of the body wall and the limb(s), anomalies of the internal organs were found in three fetuses, suggesting a disturbance of normal morphogenesis before the fifth week of development. When analyzing the observed data in relation to their etiology, no support was found for either the amniotic band or the vascular disruption theory. New insights into morphogenesis suggest that the limb body wall malformation complex results from a malfunction in the ectodermal placodes and that it can be considered to be an embryonic dysplasia.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Hartwig NG,Vermeij-Keers C,De Vries HE,Kagie M,Kragt Hdoi
10.1016/0046-8177(89)90225-6subject
Has Abstractpub_date
1989-11-01 00:00:00pages
1071-7issue
11eissn
0046-8177issn
1532-8392pii
0046-8177(89)90225-6journal_volume
20pub_type
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