Is cervical screening working? A cytopathologist's view from the United Kingdom.

abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...

journal_title：Human pathology

authors： Turner JR,Odze RD,Crum CP,Resnick MB

更新日期：1997-06-01 00:00:00

abstract：:This study investigate the expression of the mitogen-activated protein kinases (MAPKs) in normal prostate, benign prostatic hyperplasia (BPH), and prostatic cancer (PC), and also the possible relationship between the activity of these MAPKs and the apoptosis/proliferation index. Immunochemical techniques were carried ...

journal_title：Human pathology

authors： Royuela M,Arenas MI,Bethencourt FR,Sánchez-Chapado M,Fraile B,Paniagua R

更新日期：2002-03-01 00:00:00

abstract：:T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...

journal_title：Human pathology

authors： Hu Z,Li S,Medeiros LJ,Sun T

更新日期：2017-07-01 00:00:00

abstract：:Astrocytoma grade IV (glioblastoma multiforme) is the most common and most malignant tumor of the central nervous system and is currently noncurable. Here, we have examined a population-based cohort of 47 patients with grade IV astrocytoma, who underwent tumor surgery at Sahlgrenska University Hospital in Sweden and w...

journal_title：Human pathology

authors： Skalli O,Wilhelmsson U,Orndahl C,Fekete B,Malmgren K,Rydenhag B,Pekny M

更新日期：2013-10-01 00:00:00

abstract：:The intraoperative diagnosis of pulmonary neuroendocrine tumors can be difficult. Frozen section diagnosis was requested on 87 neuroendocrine tumors including 58 typical carcinoids, 8 atypical carcinoids, 18 large cell neuroendocrine carcinomas, and 3 small cell carcinomas from 2405 patients that underwent frozen sect...

journal_title：Human pathology

authors： Gupta R,Dastane A,McKenna RJ Jr,Marchevsky AM

更新日期：2009-01-01 00:00:00

abstract：:The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...

journal_title：Human pathology

authors： Dobashi Y,Suzuki S,Kimura M,Matsubara H,Tsubochi H,Imoto I,Ooi A

更新日期：2011-02-01 00:00:00

abstract：:Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (rang...

journal_title：Human pathology

authors： Li P,Zhang D,Zhou J,Li P,Shen Y,Pan Z,Evans AG,Liao X

更新日期：2020-12-01 00:00:00

abstract：:Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial cells. Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is...

journal_title：Human pathology

authors： Arora K,Miller R,Mullick S,Shen S,Ayala AG,Ro JY

更新日期：2018-01-01 00:00:00

abstract：:The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the diagnosis...

journal_title：Human pathology

authors： Lyda MH,Weiss LM

更新日期：2000-08-01 00:00:00

abstract：:Lymphocytic colitis (LC) and LC incomplete (LCi) are common causes of chronic watery diarrhea. The diagnosis relies on clinical findings and histopathologic evaluation. The diagnostic criteria of LC are based on hematoxylin and eosin (HE) staining. However, supplementary immunohistochemical staining for highlighting t...

journal_title：Human pathology

authors： Fiehn AK,Clausen LN,Engel U,Wildt S,Munck LK,Kristensson M,Engel PJH

更新日期：2019-02-01 00:00:00

abstract：:Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...

journal_title：Human pathology

authors： Magro C,Crowson AN,Kovatich A,Burns F

更新日期：2002-08-01 00:00:00

abstract：:The concept of minimal deviation melanoma is presented in diagrammatic form. In this approach, the precursors of melanoma are presented as having two dimensions and melanomas as having three dimensions. In turn, the relativity between dimensionalities and recommendations for treatment (as indirect correlates of progno...

journal_title：Human pathology

authors： Reed RJ

更新日期：1999-05-01 00:00:00

abstract：:Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...

journal_title：Human pathology

authors： Veinot JP,Gattinger DA,Fliss H

更新日期：1997-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...

journal_title：Human pathology

authors： Ascoli V,Lo Coco F,Artini M,Levrero M,Fruscalzo A,Mecucci C

更新日期：1997-01-01 00:00:00

abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...

journal_title：Human pathology

authors： MacQuarrie E,Arnason T,Gruchy J,Yan S,Drucker A,Huang WY

更新日期：2012-08-01 00:00:00

abstract：:Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profi...

journal_title：Human pathology

authors： Munari E,Marchionni L,Chitre A,Hayashi M,Martignoni G,Brunelli M,Gobbo S,Argani P,Allaf M,Hoque MO,Netto GJ

更新日期：2014-06-01 00:00:00

abstract：:FoxA1 regulates a variety of tissues during embryogenesis and early life. In thyroid, FoxA1 expression has recently been shown in C cells and medullary thyroid carcinomas but not in follicular cells. FoxA1 has also been proposed as a potential oncogene in anaplastic thyroid carcinomas. However, FoxA1 expression has no...

journal_title：Human pathology

authors： Nonaka D

更新日期：2017-07-01 00:00:00

abstract：:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...

journal_title：Human pathology

authors： Silver MM,Vilos GA,Silver MD,Shaheed WS,Turner KL

更新日期：1984-12-01 00:00:00

abstract：:In an attempt to identify patients best suited for limited surgery as well as those at risk for recurrence and increased mortality, the authors reviewed the clinical and pathologic features of 130 patients who had undergone partial mastectomy as primary treatment for breast cancer (adjuvant therapy was administered on...

journal_title：Human pathology

authors： Lash RH,Bauer TW,Hermann RE,Esselstyn CB

更新日期：1986-08-01 00:00:00

abstract：:The relationship between nuclear diameter and biologic behavior was studied in 127 cases of thyroid carcinoma. Using a sonic digitizer coupled to a minicomputer, nuclear diameters of 200 randomly selected cancer cells from each case (hematoxylineosin-stained paraffin sections) projected at X 400 magnification were tra...

journal_title：Human pathology

authors： Lee TK,Myers RT,Bond MG,Marshall RB,Kardon B

更新日期：1987-12-01 00:00:00

abstract：:Tubular carcinoma of the breast is a well-differentiated variant of invasive ductal carcinoma and has been shown to have an exceptionally favorable prognosis, as manifested by a low incidence of lymph node metastases and an excellent overall survival. It is unknown whether this subtype represents an early step along t...

journal_title：Human pathology

authors： Waldman FM,Hwang ES,Etzell J,Eng C,DeVries S,Bennington J,Thor A

更新日期：2001-02-01 00:00:00

abstract：:Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marr...

journal_title：Human pathology

authors： Osborne BM,Guarda LA,Butler JJ

更新日期：1984-11-01 00:00:00

abstract：:Trefoil factors are wound-healing peptides important in protection and healing of the human gastrointestinal tract. Their potential for therapy of gastrointestinal ulcers has been established. This study investigated the hypothesis that trefoil factors are also present in human salivary gland. Tissues from surgical bi...

journal_title：Human pathology

authors： Devine DA,High AS,Owen PJ,Poulsom R,Bonass WA

更新日期：2000-04-01 00:00:00

abstract：:Thirty cases of ductal carcinoma in situ (DCIS) of the breast, showing histological microcalcifications, were studied to clarify their mechanism of formation. Undecalcified sections revealed three types of calcium precipitates: type I and II granular calcifications (GCs) and laminar calcifications (LCs). In type I GCs...

journal_title：Human pathology

authors： Foschini MP,Fornelli A,Peterse JL,Mignani S,Eusebi V

更新日期：1996-02-01 00:00:00

abstract：:Disruptions of the p16-CDK4/cyclin D1-pRb pathway (RB pathway) and the p14ARF-MDM2-p53 pathway (p53 pathway) are important mechanisms in the development of human malignancies. In this study, we investigated RB and p53 pathways in 46 epithelial ovarian cancers (EOCs). In the RB pathway, 16 (34.8%) of 46 cases had p16 g...

journal_title：Human pathology

authors： Hashiguchi Y,Tsuda H,Yamamoto K,Inoue T,Ishiko O,Ogita S

更新日期：2001-09-01 00:00:00

abstract：:Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...

journal_title：Human pathology

authors： Furuhata S,Kameya T,Otani M,Toya S

更新日期：1993-01-01 00:00:00

abstract：:Esophageal cancer is one of the most fatal cancers worldwide and is characterized by great variation in rates among different populations. Linxian, a county in Henan Province, located in north-central China, has one of the highest rates of esophageal squamous cell carcinoma in the world. Most squamous cell carcinomas ...

journal_title：Human pathology

authors： Roth MJ,Guo-Qing W,Lewin KJ,Ning L,Dawsey SM,Wesley MN,Giffen C,Yong-Qiang X,Maher MM,Taylor PR

更新日期：1998-11-01 00:00:00

abstract：:We applied a panel of antibodies to formalin-fixed, paraffin-embedded sections of 55 renal cell carcinomas using a three-stage immunoperoxidase technique. The antibody panel included two anti-keratins, AE1 and CAM5.2, anti-epithelial membrane antigen (EMA), anti-vimentin, anti-S100 protein, and the anti-leukocyte mark...

journal_title：Human pathology

authors： Medeiros LJ,Michie SA,Johnson DE,Warnke RA,Weiss LM

更新日期：1988-08-01 00:00:00

abstract：:This article reviews 281 malignant germ cell tumors of the ovary from the Armed Forces Institute of Pathology and highlights their distinctive clinical and pathologic features. Emphasis is placed on the importance of a combined therapeutic approach utilizing surgery, chemotherapy, and radiation. The rationale for unil...

journal_title：Human pathology

authors： Kurman RJ,Norris HJ

更新日期：1977-09-01 00:00:00

abstract：:A 60-year-old man was admitted for progressive visual loss in both eyes. He was diagnosed with retinopathy and chest computed tomography revealed an invasive thymoma. In western blot analysis, serum autoantibodies against recoverin, photoreceptor-specific calcium-binding protein, and heat shock cognate protein 70 whic...

journal_title：Human pathology

authors： Yamada G,Ohguro H,Aketa K,Itoh T,Shijubo N,Takahashi H,Fujiwara O,Satoh M,Ohtsuka K,Abe S

更新日期：2003-07-01 00:00:00