Abstract：
:Cytogenetic analysis of short-term cultures from 34 benign colorectal polyps, all histologically verified as adenomas, revealed clonal chromosome aberrations in 21 of them. Eight polyps had structural rearrangements, whereas only numerical changes were found in 13. A combination of structural and numerical chromosomal aberrations was found in three polyps. The most common numerical change was gain of chromosome 7, found either as the sole anomaly (five polyps), together with other numerical changes (six polyps), or together with structural rearrangements (two polyps). Other recurrent numerical changes were +20, +13, and monosomy 18, found in six, five, and two adenomas, respectively. Rearrangement of chromosome 1 was the most common structural change. Abnormalities involving 1p were seen in six adenomas, leading to visible loss of material in three. One adenoma had one clone with a large and another with a small 1p deletion. In three adenomas, del(1)(p36) was the only cytogenetic aberration, supporting the authors' previous conclusion that loss of one or more gene loci in band 1p36 is a common early change in colorectal tumorigenesis. Chromosome 8 was involved in structural changes in two adenomas; in one this led to loss of 8p and in the other to gain of 8q. The cytogenetic findings did not correlate in a statistically significant manner with clinicopathologic parameters, such as grade of dysplasia, macroscopic or microscopic adenoma structure, tumor size and location, or the patients' sex and age.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Bomme L,Bardi G,Pandis N,Fenger C,Kronborg O,Heim Sdoi
10.1016/s0046-8177(96)90314-7subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1192-7issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(96)90314-7journal_volume
27pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:This study tested whether concordance could be achieved for abnormal inflammation in the basal decidua of placental specimens among 6 pathologists experienced in placental pathology. Thirty microscope slides were evaluated by the pathologists for chronic deciduitis. They also scored the severity and extent of inflamma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80241-5
更新日期：2000-03-01 00:00:00
abstract：:Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.010
更新日期：2004-10-01 00:00:00
abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.002
更新日期：2012-08-01 00:00:00
abstract：:Two extraskeletal myxoid chondrosarcomas were examined by electron microscopy. In addition to the well-described ultrastructural features indicative of chondroblastic origin, both of these chondrosarcomas had unusual parallel microtubules packed within rough endoplasmic reticulum. This paper reviews the differential d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80036-3
更新日期：1986-05-01 00:00:00
abstract：:Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.003
更新日期：2013-10-01 00:00:00
abstract：:Several matrix metalloproteinases (MMPs) are implicated in the degradation of the epithelial basement membrane (BM), invasiveness, and malignancy of endometrial and ovarian carcinomas. We have recently proposed a cooperative role for RUNX1/AML1 and ETV5/ERM in myometrial infiltration during endometrioid endometrial in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.01.025
更新日期：2011-01-01 00:00:00
abstract：:Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:Although rare, synovial sarcoma (SS) is one of the most common soft tissue sarcomas affecting young adults. To investigate potential tumor markers related to synovial sarcoma prognosis, we carried out a single-institution retrospective analysis of 103 patients diagnosed with SS between 1980 and 2009. Clinical outcome ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.001
更新日期：2013-09-01 00:00:00
abstract：:Astrocytoma grade IV (glioblastoma multiforme) is the most common and most malignant tumor of the central nervous system and is currently noncurable. Here, we have examined a population-based cohort of 47 patients with grade IV astrocytoma, who underwent tumor surgery at Sahlgrenska University Hospital in Sweden and w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.013
更新日期：2013-10-01 00:00:00
abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90185-4
更新日期：1997-06-01 00:00:00
abstract：:Esophageal and colorectal adenocarcinomas overexpress Fas ligand (FasL), which can protect them from immune surveillance. The aim of this work was to determine whether FasL expression, and therefore FasL-dependent immune evasion, occurs early during malignant transformation in Barrett's metaplasia (BM) of the esophagu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90061-8
更新日期：1999-11-01 00:00:00
abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90040-0
更新日期：1999-10-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major efforts is being made to identify molecular markers capable to differentiate oral potentially malignant lesions (OPMLs) with indolent course from lesions with aggressive behavior. We undertook a study to evaluate if gain of the human telomer...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.05.013
更新日期：2015-09-01 00:00:00
abstract：:The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the diagnosis...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.9076
更新日期：2000-08-01 00:00:00
abstract：:This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80103-7
更新日期：1976-09-01 00:00:00
abstract：:We have previously shown that necrotic tumors retain their immunoreactivity for a range of cytokeratin antibodies. Some thyroid tumors undergo extensive necrosis after fine-needle aspiration (FNA) procedures. We evaluated the sensitivity of antibodies on necrotic thyroid tumors by examining a series of thyroid tumors ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90071-0
更新日期：1999-11-01 00:00:00
abstract：:A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90199-x
更新日期：1998-09-01 00:00:00
abstract：:The light microscopic diagnosis of large cell undifferentiated carcinoma of the lung is known to be highly subjective and shows poor interobserver reproducibility; the very existence of this tumor as a separate entity has been challenged. The ultrastructure of seven large cell undifferentiated carcinomas was examined ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80105-1
更新日期：1978-03-01 00:00:00
abstract：:Ultrastructural features of bilateral testicular biopsy materials, obtained from both tumor and nontumor areas of the testis of a 27-year-old man with congenital adrenal hyperplasia, revealed a number of pathologic changes. Germ cell hypoplasia and extratubular cellular hyperplasia were noticed in the nontumor portion...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80244-5
更新日期：1983-02-01 00:00:00
abstract：:Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90145-0
更新日期：1995-04-01 00:00:00
abstract：:Reactive bone marrow mast cells reliably lack the morphologic, immunophenotypic, and molecular features of systemic mastocytosis (SM). We report two unusual cases of acquired aplastic anemia (AA) in which multifocal aggregates of bone marrow mast cells fulfilled morphologic and immunophenotypic criteria for SM accordi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.08.002
更新日期：2014-02-01 00:00:00
abstract：:Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic malignancy and is one of the best understood neoplasms, with relatively well-defined pathogenetic pathways, natural history, and tumor biology. Conventional clinical and pathologic parameters are widely used to grade and stage t...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2010.07.007
更新日期：2011-04-01 00:00:00
abstract：:Pseudomonas pneumonia is an uncommon but serious infection in infants, occurring mainly in infants of low birth weight. In this retrospective clinicopathologic correlation study, we reviewed the clinical records and analyzed postmortem lung pathology in 8 infants with pneumonia due to P. aeruginosa. From the histopath...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00353-8
更新日期：2003-09-01 00:00:00
abstract：:Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.05.016
更新日期：2014-09-01 00:00:00
abstract：:A small number (4% to 6%) of primary malignant lymphomas arising in the intestines express the EBV genome. However, in these tumors, the viral genotype and the role of tumor suppressor gene p53 have not been investigated. We sought to determine what genotype of EBV is frequently involved and whether the expression of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90030-8
更新日期：1999-10-01 00:00:00
abstract：:Invasive mammary carcinoma with neuroendocrine differentiation has been controversial in terms of its definition and clinical outcome. In 2003, the World Health Organization histologic classification of tumors designated this entity as neuroendocrine carcinoma of the breast and defined mammary neuroendocrine carcinoma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.014
更新日期：2011-08-01 00:00:00
abstract：:Lymphocytic colitis, previously termed "microscopic colitis", is a clinicopathologic syndrome of watery diarrhea, grossly normal colonoscopy, and mucosal inflammatory changes. Since lymphocytic colitis is a new, incompletely characterized entity, a histopathologic study was performed to compare lymphocytic colitis (n ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90198-6
更新日期：1989-01-01 00:00:00
abstract：:A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90017-8
更新日期：1989-05-01 00:00:00
abstract：:The spectrum of neuroendocrine (NE) tumors in the genitourinary tract ranges from the aggressive large and small cell carcinomas to the often benign paraganglioma and well-differentiated neuroendocrine tumor (WD-NET). At least 15 pure lower urinary tract (LUT) WD-NETs have been described. Owing to the rarity of WD-NET...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.11.014
更新日期：2020-12-08 00:00:00
abstract：:PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.07.023
更新日期：2015-12-01 00:00:00
