Follicular dendritic cells: origin, function, and different disease-associated patterns.

abstract：:Mantle cell lymphoma (MCL) is typically characterized by t(11;14), which places the IGH@ enhancer elements upstream of CCND1. This fusion results in up-regulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untransl...

journal_title：Human pathology

authors： Menke JR,Vasmatzis G,Murphy S,Yang L,Menke DM,Tun HW,King RL,Smoley SA,Ketterling RP,Sukov WR

更新日期：2017-06-01 00:00:00

abstract：:The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...

journal_title：Human pathology

authors： Johnson DN,Sadow PM

更新日期：2018-12-01 00:00:00

abstract：:Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...

journal_title：Human pathology

authors： Haupt B,Schwartz MR,Xu Q,Ro JY

更新日期：2010-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...

journal_title：Human pathology

authors： Ascoli V,Lo Coco F,Artini M,Levrero M,Fruscalzo A,Mecucci C

更新日期：1997-01-01 00:00:00

abstract：:In this series of 3,432 cases of malignant melanoma of the choroid and ciliary body, mortality from metastasis 15 years after enucleation was 46 per cent. This mortality was at least ten times greater than has been observed with tumors of the iris, probably owing to the greater size and more malignant cytology of chor...

journal_title：Human pathology

authors： McLean IW,Foster WD,Zimmerman LE

更新日期：1982-02-01 00:00:00

abstract：:Glial tumors of the retina are rare. Most are syndrome associated and include pilocytic astrocytoma in neurofibromatosis type 1 and subependymal giant cell astrocytoma in tuberous sclerosis complex. Acquired, more conventional, diffuse astrocytomas are less frequent. Ependymoma is exquisitely rare. Herein, we report t...

journal_title：Human pathology

authors： Tay A,Scheithauer BW,Cameron JD,Myhre MJ,Boerner MJ

更新日期：2009-04-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...

journal_title：Human pathology

authors： Nohr E,Girard L,James M,Benediktsson H

更新日期：2014-07-01 00:00:00

abstract：:Cancer-related axonogenesis and neurogenesis are recently described biologic phenomena. Our previously published data showed that nerve density and the number of neurons in the parasympathetic ganglia are increased in prostate cancer (PCa) and associated with aggressive disease. Tissue microarrays were constructed fro...

journal_title：Human pathology

authors： Olar A,He D,Florentin D,Ding Y,Ayala G

更新日期：2014-07-01 00:00:00

abstract：:A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...

journal_title：Human pathology

authors： Park WS,Vortmeyer AO,Pack S,Duray PH,Böni R,Guerami AA,Emmert-Buck MR,Liotta LA,Zhuang Z

更新日期：1998-02-01 00:00:00

abstract：:Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant pure type being mainly virus positive. Indications that different bi...

journal_title：Human pathology

authors： Lai JH,Fleming KE,Ly TY,Pasternak S,Godlewski M,Doucette S,Walsh NM

更新日期：2015-09-01 00:00:00

abstract：:The evolution of sequential histological changes from normal cells through invasive cancer affords the cancer biologist the opportunity to identify separate molecular steps involved in cancer progression. As one studies the development of human carcinoma, it becomes apparent that multiple genetic alterations affecting...

journal_title：Human pathology

authors： Stemmermann G,Heffelfinger SC,Noffsinger A,Hui YZ,Miller MA,Fenoglio-Preiser CM

更新日期：1994-10-01 00:00:00

abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...

journal_title：Human pathology

authors： Kaluza V,Rao DS,Said JW,de Vos S

更新日期：2006-06-01 00:00:00

abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...

journal_title：Human pathology

authors： Hervieu V,Christa L,Gouysse G,Bouvier R,Chayvialle JA,Bréchot C,Scoazec JY

更新日期：2006-08-01 00:00:00

abstract：:Although mast cell proliferation in the bone marrow frequently occurs in systemic mastocytosis and is often associated with radiographically detectable bone lesions, the pathologic correlates of the skeletal abnormalities are poorly characterized. We therefore examined three nondecalcified transiliac crest biopsy spec...

journal_title：Human pathology

authors： Fallon MD,Whyte MP,Teitelbaum SL

更新日期：1981-09-01 00:00:00

abstract：:Two hundred three testicular germ cell tumors were studied immunohistochemically for the presence of placental alkaline phosphatase (PLAP). Special emphasis was placed on the pattern and incidence of positive staining of intratubular malignant germ cells (ITMGCs) adjacent to tumors. 99% of cases with adjacent ITMGCs s...

journal_title：Human pathology

authors： Burke AP,Mostofi FK

更新日期：1988-06-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...

journal_title：Human pathology

authors： Bhardwaj M,Sen S,Sharma A,Kashyap S,Chosdol K,Pushker N,Bajaj MS,Bakhshi S

更新日期：2015-10-01 00:00:00

abstract：:Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marr...

journal_title：Human pathology

authors： Osborne BM,Guarda LA,Butler JJ

更新日期：1984-11-01 00:00:00

abstract：:Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....

journal_title：Human pathology

authors： Margraf LR,Paciga JE,Balis JU

更新日期：1990-04-01 00:00:00

abstract：:The diagnosis of metastatic adenocarcinoma to the brain of unknown primary is problematic, and the role of immunohistochemistry in identifying a source has not been fully characterized. Sixty-eight metastatic adenocarcinomas of the brain with known primaries were immunostained with antibodies to cytokeratin 7 (CK7), c...

journal_title：Human pathology

authors： Perry A,Parisi JE,Kurtin PJ

更新日期：1997-08-01 00:00:00

abstract：:Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...

journal_title：Human pathology

authors： Baker PM,Young RH

更新日期：2000-06-01 00:00:00

abstract：:Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...

journal_title：Human pathology

authors： Kleinschmidt-Demasters BK,Evans LC,Bobak JB,Lopez-Uribe D,Hopper D,Shroyer AL,Shroyer KR

更新日期：2000-08-01 00:00:00

abstract：:Posttransplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV), and may clinically resemble acute allograft rejection. Three methods to show EBV in tissue were evaluated in 15 liver allograft biopsies from 12 patients including four with PTLD: (1) semiquantitative polymerase chain react...

journal_title：Human pathology

authors： Lones MA,Shintaku IP,Weiss LM,Thung SN,Nichols WS,Geller SA

更新日期：1997-05-01 00:00:00

abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...

journal_title：Human pathology

authors： Kataoka Y,Shimada H,Sugimoto T,Mine H,Hachitanda Y,Doi Y,Sawada T,Weeks DA

更新日期：1993-09-01 00:00:00

abstract：:Promyelocytic leukemia zinc finger is a zinc finger transcription factor that functions as a transcriptional repressor. Its expression has been shown to be down-regulated in hematopoietic, melanocytic, and mesothelial malignancies. Histone H1.5 is a variant of histone H1, a family of linker proteins that organizes chr...

journal_title：Human pathology

authors： Hechtman JF,Beasley MB,Kinoshita Y,Ko HM,Hao K,Burstein DE

更新日期：2013-07-01 00:00:00

abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...

journal_title：Human pathology

authors： Yu J,Monaco SE,Onisko A,Bhargava R,Dabbs DJ,Cieply KM,Fine JL

更新日期：2013-03-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) status is useful for predicting response to trastuzumab. Fluorescence in situ hybridization (FISH) for HER2 gene amplification is accurate but limited because of cost, the need for fluorescence microscopy, the limited assessment of histology, and the fading of its signal...

journal_title：Human pathology

authors： Lim SJ,Cantillep A,Carpenter PM

更新日期：2013-11-01 00:00:00

abstract：:Grade Group (GG) 4 prostate cancer includes Gleason scores (GS) 3 + 5 = 8, 4 + 4 = 8, and 5 + 3 = 8. Some studies without pathology re-review of historical cohorts proposed that the presence of pattern 5 worsens prognosis compared to GS 4 + 4 = 8 cancer. We assessed how often historically graded GS 5 + 3 = 8 cancers r...

journal_title：Human pathology

authors： Kryvenko ON,Williamson SR,Schwartz LE,Epstein JI

更新日期：2020-03-01 00:00:00

abstract：:Bone Marrow Transplant (BMT) is a critical therapeutic intervention for a variety of diseases occurring in the pediatric patient. Complications of allogeneic BMT include graft-versus-host disease (GVHD), infection, drug toxicity, thrombotic microangiopathy, and veno-occlusive disease. With solid organ transplantation,...

journal_title：Human pathology

authors： Selby DM,Rudzki JR,Bayever ES,Chandra RS

更新日期：1999-07-01 00:00:00

abstract：:We have experienced an autopsy case of a 20-year-old woman with bronchiolitis obliterans, pemphigus vulgaris, and Castleman's disease. The affected bronchioles showed almost the same histology as previously described. But, the number of the lesions seemed too small to cause her death of respiratory insufficiency. We a...

journal_title：Human pathology

authors： Saito K,Morita M,Enomoto K

更新日期：1997-11-01 00:00:00

abstract：:A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparen...

journal_title：Human pathology

authors： Pecorella I,Ciardi A,Amadeo G,Baiocchini A,Marasco A,Di Tondo U

更新日期：2000-12-01 00:00:00