Suprachiasmatic lesions eliminate 24-h blood pressure variability in rats.

Abstract:

:To evaluate whether the suprachiasmatic nuclei (SCN) control 24-h rhythmicity in cardiovascular function, rats were subjected to computerized recording of 24-h blood pressure (BP) and heart rate (HR) following SCN lesions. In sham- and nonlesioned rats, circadian patterns of BP and HR ran in phase with those in feeding behavior. In SCN-lesioned rats circadian rhythmicity in BP, HR and food intake were abolished. Minute-to-minute variation of BP and HR was similar as in sham- and nonlesioned rats. We conclude that long-term but not short-term variability of blood pressure and heart rate is largely determined by SCN-controlled activity levels.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Janssen BJ,Tyssen CM,Duindam H,Rietveld WJ

doi

10.1016/0031-9384(94)90138-4

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

307-11

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031-9384(94)90138-4

journal_volume

55

pub_type

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