Abstract：
:Recently, the polymorphism of a new human platelet antigen, Ca/Tu, was shown to be derived from a G-A nucleotide substitution at base 1564 of GPIIIa cDNA, which leads to a single amino acid difference, Arg/Gln at amino acid 489 of GPIIIa. We developed a PCR-RFLP method to determine the genotypes of Ca/Tu and their frequencies in a Japanese population. Fifteen Ca/Tua donors comprising 1 Ca/Tu(a/a) homozygous donor and 14 Ca/Tu(a/b) heterozygous donors were found among the 314 random donors analyzed. The frequencies of Ca/Tu genes were 0.025 (Ca/Tua) and 0.975 (Ca/Tu(b)). The present study showed that the frequency of Ca/Tua individuals in the Japanese (15/314) was approximately 7-fold higher than in the Finnish population (1/150) previously reported by Kekomäki et al. Therefore, attention must be given to the involvement of the Ca/Tu alloantigen in neonatal alloimmune thrombocytopenia and the refractoriness of platelet transfusion.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Tanaka S,Taniue A,Nagao N,Tomita T,Ohnoki S,Shibata H,Okubo Y,Yamaguchi H,Shibata Ydoi
10.1111/j.1423-0410.1996.tb00995.xsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
40-4issue
1eissn
0042-9007issn
1423-0410journal_volume
70pub_type
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