Abstract:
BACKGROUND AND OBJECTIVES:Leucocyte-derived cytokines accumulate in stored whole blood. Pre-storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non-haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesized that within this time, inflammatory cytokines might accumulate. MATERIALS AND METHODS:Serial plasma samples were collected 4, 10 and 20 h after donation and cytokine concentrations were measured. RESULTS:Interleukin-8 increased > 20-fold and soluble CD40 ligand > sixfold during the observation time, less pronounced changes for several other mediators were also observed. CONCLUSION:Leucocyte depletion within 10 h of blood donation will reduce the concentrations of pyrogenic mediators.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Chudziak D,Sireis W,Pfeiffer HU,Henschler R,Seifried E,Bönig Hdoi
10.1111/j.1423-0410.2008.01132.xsubject
Has Abstractpub_date
2009-02-01 00:00:00pages
163-6issue
2eissn
0042-9007issn
1423-0410pii
VOX1132journal_volume
96pub_type
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