Flow-cytometric method for the quantitation of the Fc function of intravenous immunoglobulin preparations.

abstract：BACKGROUND AND OBJECTIVES:Apheresis platelet concentrates sometimes contain persistent aggregates (PA). Because apheresis involves extracorporeal circulation, we hypothesized that interactions between GPIbα and von Willebrand factor (VWF) underlie their origin. MATERIALS AND METHODS:Platelets in donations with PA were...

journal_title：Vox sanguinis

authors： Feys HB,Van Aelst B,Devloo R,Vandekerckhove P,Compernolle V

更新日期：2016-05-01 00:00:00

abstract：:Significantly more peripheral blood mononuclear cells (PBM) from 39 patients with lymphoma (p less than 0.001), myeloma (p less than 0.001), or leukemia (p less than 0.001-0.025) bind transferrin (Trf) than those of 23 normals. That Trf was bound to a receptor on these cells was shown by the inhibition of these cells ...

journal_title：Vox sanguinis

authors： Yeh CJ,Taylor CG,Faulk WP

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Previous studies with p38MAPK inhibitors at room temperature demonstrated that they improve a large number of platelet storage parameters, but cannot substantially inhibit p38MAPK activation nor protect against widespread decrements in platelet quality parameters during 4 °C storage. In this s...

journal_title：Vox sanguinis

authors： Wagner SJ,Skripchenko A,Seetharaman S,Kurtz J

更新日期：2015-04-01 00:00:00

abstract：:In this prospective study, 26 consecutive patients being treated for haematological malignancies receiving standard (i.e. non-leucocyte-depleted) blood components were observed for the development of refractoriness to platelet transfusions. One hundred and sixteen of the 266 (44%) platelet transfusions failed to produ...

journal_title：Vox sanguinis

authors： Doughty HA,Murphy MF,Metcalfe P,Rohatiner AZ,Lister TA,Waters AH

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Photochemical treatment (PCT) of platelet concentrates using photosensitizers and ultraviolet light illumination reduces the proliferation potential of pathogens by damaging biomolecules. MATERIALS AND METHODS:The impact of riboflavin (RF-PRT)- and amotosalen (AS-PCT)-based pathogen inactivation on platelet...

journal_title：Vox sanguinis

authors： Van Aelst B,Feys HB,Devloo R,Vanhoorelbeke K,Vandekerckhove P,Compernolle V

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:There exists only few data on in vitro and in vivo effects of gamma irradiation of leucoreduced red blood cells (RBCs). Reported studies reflect the effects of early irradiation and subsequent storage. The effects of irradiation on RBCs shortly before the end of their shelf-life have not been examined. STUD...

journal_title：Vox sanguinis

authors： Zimmermann R,Schoetz AM,Frisch A,Hauck B,Weiss D,Strobel J,Eckstein R

更新日期：2011-04-01 00:00:00

abstract：:We have studied the IgE content of different lots of commercial intravenous IgG preparations used in our day hospital as replacement therapy for patients with agammaglobulinemia. Two enzymatic methods were used: Phadezym and FAST. The average amounts of IgE detected in Endobulin and Sandoglobulin lots were very high w...

journal_title：Vox sanguinis

authors： Paganelli R,Quinti I,D'Offizi GP,Papetti C,Cabello A,Aiuti F

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A large number of European blood centres, including our own, use the buffy-coat method for platelet production. In this article we describe a previously unnoticed phenomenon shown by a proportion of buffy-coats, which display an unusually bright cherry colour and low platelet counts. MATERIAL...

journal_title：Vox sanguinis

authors： Rebulla P,Smacchia C,Greppi N,Porretti L,Lopa R,Cernuschi M,Sirchia G

更新日期：2001-01-01 00:00:00

abstract：:Low-dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low-dose protocols appeared in 1981, described small numbers...

journal_title：Vox sanguinis

authors： Sultan Y

更新日期：1999-01-01 00:00:00

abstract：:A family is reported in which the parents' mating is of the 'double back-cross' type with respect to the Sw, Lu and Se genes. The inheritance of these genes in the children shows, with reference to a possible linkage between Sw and the two other loci, four non-recombinants and three recombinants (or vice versa). The i...

journal_title：Vox sanguinis

authors： Metaxas MN,Metaxas-Buehler M

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVES:Reconstitution of hematopoiesis by means of peripheral blood stem cells is a valid alternative to autologous bone marrow transplantation. The aim of this investigation was to increase the efficiency of collection of circulating blood progenitor cells and to obtain a purer product for transplant. METHODS:We ...

journal_title：Vox sanguinis

authors： Menichella G,Lai M,Pierelli L,Vittori M,Serafini R,Ciarli M,Foddai ML,Salerno G,Sica S,Scambia G,Leone G,Bizzi B

更新日期：1997-01-01 00:00:00

abstract：:Isoagglutinins were investigated following ABO-incompatible bone marrow transplantation. In major incompatibility anti-A tends to require more time to disappear than anti-B. Correspondingly, A erythrocytes require more time to become demonstrable. There is no such difference in major plus minor incompatibility. In min...

journal_title：Vox sanguinis

authors： Wernet D,Mayer G

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Despite long being a mainstay in describing platelet activation via degranulation, interlaboratory variation remains an issue in measurement of membrane CD62P by flow cytometry. Our objective was to identify actions that may minimize this variation. MATERIALS AND METHODS:Sixteen laboratories ...

journal_title：Vox sanguinis

authors： Levin E,Serrano K,Devine DV,Biomedical Excellence for Safer Transfusion (BEST) Collaborative.

更新日期：2013-07-01 00:00:00

abstract：:Bivalent 7S subunits were obtained from 7 purified IgM human monoclonal anti-D antibodies with 33-63% of the total protein-retaining functional binding activity. The number of sites per red cell recognized by these subunits ranged between 9,400 and 28,500. The values are taken to indicate that a number of different ep...

journal_title：Vox sanguinis

authors： Hughes-Jones NC,Gorick BD,Beale D

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:While blood is flowing within a transfusion-warming device, the blood temperature is usually less than that applied externally. If the flow is temporarily stopped, the temperature can rise above 37 degrees C in some warming devices. We sought to determine whether temperatures near 45 degrees C...

journal_title：Vox sanguinis

authors： Eastlund T,Van Duren A,Clay ME

更新日期：1999-01-01 00:00:00

abstract：:We report a new platelet antigen (Yuka) defined by the sera of 2 mothers whose babies developed alloimmune thrombocytopenia. These antiplatelet antibodies were IgG detected by Mixed Passive Hemagglutination (MPHA). In the study of two families, the Yuka antigen was found to be inherited as an autosomal dominant trait....

journal_title：Vox sanguinis

authors： Shibata Y,Matsuda I,Miyaji T,Ichikawa Y

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We compared three methods of isolating platelet-rich plasma (PRP) using the Haemonetics Cell Saver 5 and one method of isolating PRP by plateletpheresis using the Haemonetics MCS+. PRP contains both platelets and fibrinogen, which are used in the preparation of haemostatic agents. MATERIALS A...

journal_title：Vox sanguinis

authors： O'Neill EM,Zalewski WM,Eaton LJ,Popovsky MA,Pivacek LE,Ragno G,Valeri CR

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:GB virus C (GBV-C)/hepatitis G virus (HGV) is a recently recognized parenterally and sexually transmitted agent. The prevalence of GBV-C/HGV markers in Canadian blood donors has not been previously studied and was therefore determined. MATERIALS AND METHODS:Blood donors [identity unlinked (IU...

journal_title：Vox sanguinis

authors： Giulivi A,Slinger R,Tepper M,Sher G,Scalia V,Kessler G,Gill P

更新日期：2000-01-01 00:00:00

abstract：:A method is described for the production of mouse monoclonal antibodies to HBsAg. 4 clones produced antibodies directed at the a and one at the d determinant of HBsAg. These antibodies were conjugated to horse radish peroxidase and used in an Elisa for the detection of HBsAg in donated blood. Antibody C10 produced con...

journal_title：Vox sanguinis

authors： Els MC,Govender M,Marimuthu T,Bubb MO,Conradie JD

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:During the past 10 years several DNA-typing methods have been developed to complement routine serological typing for determination of polymorphisms in the ABO, RH, KEL, JK and FY blood group genes. However, the molecular basis of blood groups can differ widely between ethnic groups. The purpos...

journal_title：Vox sanguinis

authors： Irshaid NM,Ramadan S,Wester ES,Olausson P,Hellberg A,Merza JY,Olsson ML

更新日期：2002-07-01 00:00:00

abstract：:Following transfusion, red cells labeled with nonradioactive chromium (52Cr) can be detected in the circulation using atomic absorption spectrophotometry. Both in rhesus monkeys and in human subjects, the survival of red cells labeled with 52Cr was found to be insignificantly different from that of cells labeled with ...

journal_title：Vox sanguinis

authors： Sioufi HA,Button LN,Jacobson MS,Kevy SV

更新日期：1990-01-01 00:00:00

abstract：:The stabilization of human immunoglobulin (IgG) by chemically modified gelatins (Haemaccel and Gelofusine) was investigated. The gelatins prevented IgG from aggregation induced by exposure to interfaces and lyophilization. The stabilization effects of the gelatins were significantly larger than those of amino acids or...

journal_title：Vox sanguinis

authors： Tomono T,Ikeda K,Suzuki T

更新日期：1986-01-01 00:00:00

abstract：:Employing standardized IgG-coated 51Cr-labelled human red blood cells (RBC), variation in rosette formation among monolayers obtained from 10 healthy donors was defined, as well as variation among 24 sequential monolayers obtained from one healthy donor and 8 sequential monolayers from a second healthy donor over a 4-...

journal_title：Vox sanguinis

authors： Munn LR,Chaplin H Jr

更新日期：1977-09-01 00:00:00

abstract：:We have employed a PCR approach to determine the nucleotide sequences of the coding region in the last two coding exons of the histo-blood group ABO genes from one A(X) and one B(A) individual. Compared with A1 alleles, the (A(X)) allele has a single nucleotide substitution (T-->A at nucleotide 646) resulting in an am...

journal_title：Vox sanguinis

authors： Yamamoto F,McNeill PD,Yamamoto M,Hakomori S,Harris T

更新日期：1993-01-01 00:00:00

abstract：:Sera obtained from 4 mothers of children with neonatal alloimmune thrombocytopenia contained a platelet-specific alloantibody, anti-Bra, which defined an antigen apparently different from all known platelet alloantigens. All 4 fathers were Bra positive, whereas all mothers were Bra negative. The minimal postnatal valu...

journal_title：Vox sanguinis

authors： Kiefel V,Santoso S,Katzmann B,Mueller-Eckhardt C

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fetal RHD genotyping of cell-free maternal plasma DNA from RhD negative pregnant women can be used to guide targeted antenatal and postnatal anti-D prophylaxis for the prevention of RhD immunization. To assure the quality of clinical testing, we conducted an external quality assessment worksho...

journal_title：Vox sanguinis

authors： Clausen FB,Hellberg Å

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In Japan, eligibility for blood donation depends on blood specific gravity, which does not directly measure blood haemoglobin. Additionally, the criteria are not based on normal values. Therefore, we investigated the feasibility of predonation screening by using actual haemoglobin levels, and ...

journal_title：Vox sanguinis

authors： Shimoyama R,Nakase T,Kojima S,Tanaka S,Yamamori K,Kaneko C,Ishimaru K,Ikeda H

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Previous data that showed maintenance of reticulocyte percentage in whole blood stored in CPDA-1 have led to the assumption that reticulocyte maturation becomes arrested during refrigerated storage. However, reticulocyte behaviour in red-blood-cell units stored in additive solutions has not ye...

journal_title：Vox sanguinis

authors： Urbina A,Palomino F

更新日期：2013-05-01 00:00:00

abstract：:The existence of immunopotentiator factors able to induce blastogenesis, chemotaxis and able of inhibiting migration of leukocytes was investigated in alcohol precipitates of different batches of dialyzed leukocyte extracts (DLE). These were prepared either out of fresh leukocytes from a large pool of buffy coats obta...

journal_title：Vox sanguinis

authors： Arala-Chaves MP,Porto MT,Kauppinen HL,Massa AA,Myllylä G

更新日期：1982-11-01 00:00:00

abstract：:A major drawback in the use of platelet transfusions is the development of platelet refractoriness that is usually caused by alloimmunization provoked by leukocytes present in the blood products. We evaluated the development of alloimmunization both by serological demonstration of HLA antibodies and by clinical demons...

journal_title：Vox sanguinis

authors： Saarinen UM,Koskimies S,Myllylä G

更新日期：1993-01-01 00:00:00